Dynamics of proinflammatory cytokine serum levels in patients with acute inflammatory diseases of pelvic organs in the early stages of conservative treatment

Н. А. Бурова, P. A. Soltys, Н.А. Жаркин, М С Селихова, N. I. Sviridova, Eleonora B. Belan
In: Russian Journal of Infection and Immunity · 2019 · vol. 9(3-4) , pp. 612–616 · doi:10.15789/2220-7619-2019-3-4-612-616 · W2986815573
article OA: diamond CC0
🔓 Open OA copy Full text JSON View on OpenAlex View at publisher

Abstract

Dynamics of serum proinflammatory cytokines such as interleukins (IL)-1, -2 and -6, tumor necrosis factor alpha (TNFα) was examined in patients of reproductive age suffering from acute inflammatory diseases of the pelvic organs. Our study was carried out with female patients at hospital admission prior to therapy applied with conventional methods of treatment and improved treatment by using vaginal low-frequency laser in a constant continuous magnetic field. The data obtained were compared with serum cytokine level from 20 healthy female volunteers of reproductive age consulted on better contraception methods. It was found that cytokine profile of in patients with acute inflammatory processes in pelvic organs was characterized by a high level of proinflammatory cytokines. It was shown that patients receiving conventional treatment contained decreased level of serum IL-1, IL-2, IL-6 and TNFα displaying slight dynamics, which did not reach it in control group. This may contribute to ongoing inflammatory process, despite the positive clinical dynamics. In turn, imbalance of immune responses leads to a persistently impaired fertility in women and need to perform subsequent comprehensive rehabilitation measures. Moreover, patients applied with intravaginal low-frequency laser radiation in a constant magnetic field were found to contain serum TNFα 100 pg/ml observed in 59.7% of cases, IL-6 level was lower than 20 pg/ml (prevalent in control group) found in 54.2% of cases. Serum IL-2 level was decreased by 3.5-fold compared to baseline, whereas for IL-1β it was higher than 100 pg/ml in as few as 23.6% patients. Such temporal pattern of inflammatory markers with rapid significant decrease of serum proinflammatory cytokines in patients with preformed pathogenic factors can reduce probability of connective tissue formation and activate their own repair as well as regenerative events. The results obtained allow to wider use combined physical interventional factors for therapy of patients with acute inflammatory diseases of the pelvic organs.
Full text 5,214 characters · extracted from oa-doi-fallback · click to expand
Dynamics of proinflammatory cytokine serum levels in patients with acute inflammatory diseases of pelvic organs in the early stages of conservative treatment - Authors: Burova N.A.1, Soltys P.A.1, Zharkin N.A.1, Selikhova M.S.1, Sviridova N.I.1, Belan E.B.1 - Affiliations: - Volgograd State Medical University - Issue: Vol 9, No 3-4 (2019) - Pages: 612-616 - Section: SHORT COMMUNICATIONS - Submitted: 27.12.2018 - Accepted: 22.03.2019 - Published: 15.11.2019 - URL: https://iimmun.ru/iimm/article/view/923 - DOI: https://doi.org/10.15789/2220-7619-2019-3-4-612-616 - ID: 923 Cite item Full Text Abstract About the authors N. A. Burova Volgograd State Medical University Author for correspondence. Email: [email protected] PhD (Medicine), Associate Professor of the Department of Obstetrics and Gynecology, 400131, Volgograd, Pavshikh Bortsov sq., 1 Russian FederationP. A. Soltys Volgograd State Medical University Email: [email protected] Assistant Professor, Department of Obstetrics and Gynecology, Volgograd Russian FederationN. A. Zharkin Volgograd State Medical University Email: [email protected] PhD, MD (Medicine), Professor, Head of the Department of Obstetrics and Gynecology, Volgograd Russian FederationM. S. Selikhova Volgograd State Medical University Email: [email protected] PhD, MD (Medicine), Professor of the Department of Obstetrics and Gynecology, Volgograd N. I. Sviridova Volgograd State Medical University Email: [email protected] PhD, MD (Medicine), Professor, Department of Obstetrics and Gynecology, Faculty of Advanced Medical Training, Volgograd E. B. Belan Volgograd State Medical University Email: [email protected] PhD, MD (Medicine), Professor, Head of the Department of Immunology and Allergology, Faculty of Advanced Medical Training, Volgograd Russian FederationReferences - Белан Э.Б., Пахуридзе Р.Ф., Смолова Н.В., Андреева М.В. Уровень IL-8 в сыворотке крови как маркер течения воспалительного процесса у больных с гинекологической патологией // Цитокины и воспаление. 2011. Т. 10, № 3. С. 55–60. - Бурова Н.А. Современные особенности патогенеза воспалительных заболеваний органов малого таза у женщин (обзор) // Медицинский альманах. 2016. № 5 (45). С. 76–79. doi: 10.21145/2499-9954-2016-5-76-79 (In Russ.)] - Жаркин Н.А. Вагинальная рефлексотерапия гинекологических заболеваний. Волгоград: ВолгГМУ, 2014. 128 с. - Козлова Р.С., Духина А.О. Антибактериальная терапия воспалительных заболеваний органов малого таза без ошибок и экспериментов: методическое руководство для врачей // Под ред. В.Е. Радзинского. М.: Status Praesens, 2013. 16 c. - Козырева Е.В., Давидян Л.Ю. Современные методы лечения хронического эндометрита (обзор литературы) // Лечащий врач. 2015. № 12. С. 8–11. - Пестрикова Т.Ю., Юрасов И.В., Юрасова Е.А. Реабилитационная терапия как составляющая комплексного подхода к лечению хронических форм воспалительных заболеваний органов малого таза у женщин // Гинекология. 2018. Т. 20, № 5. С. 37–41. - Пестрикова Т.Ю., Юрасов И.В., Юрасова Е.А. Современный взгляд на клиническое течение, диагностику и лечение воспалительных заболеваний органов малого таза у женщин // Российский вестник акушера-гинеколога. 2015. T. 15, № 4. С. 23–28. - Прилепская В.Н., Сехин С.В. Воспалительные заболевания органов малого таза: диагностика и тактика ведения больных // Российский вестник акушера-гинеколога. 2015. T. 15, № 4. С. 101–106. doi: 10.17116/rosakush2015154101-106. (In Russ.)] - Приказ Министерства здравоохранения РФ от 01.11.2012 № 572н «Об утверждении Порядка оказания медицинской помощи по профилю «акушерство и гинекология (за исключением использования вспомогательных репродуктивных технологий - Прокопец В.И., Стрижак Д.А. Женское бесплодие воспалительного генеза // Молодой ученый. 2016. № 22.1. С. 31–34. - Трунченко Н.В., Макаров К.Ю., Соколова Т.М., Маринкин И.О. Сравнительная оценка клинической эффективности комплексной терапии хронического эндометрита с использованием пелоидов озера Карачи // Мать и дитя в Кузбасе. 2016. № 4 (67). C. 19–23. - Фадеева Н.И., Скоропацкая О.А., Левченко И.М., Кузнецова Т.А., Маркова Е.А. Прегравидарная подготовка пациенток с хроническим эндометритом и ее эффективность // Мать и дитя в Кузбассе. 2017. № 1 (68). C. 24–27. - Эллиниди В.Н., Феоктистов А.А., Лямина А.В., Обидняк Д.М., Суворова И.Ю. Хронический полипоидный и лимфофолликулярный эндометрит: гистероскопическая и гистологическая диагностика // Журнал акушерства и женских болезней. 2017. Т. 66, № 6. С. 59–65. doi: 10.17816/JOWD66659-65 (In Russ.)] - Bouet P., Hachem H., Monceau E., Gariépy G., Kadoch I.J., Sylvestre C. Chronic endometritis in women with recurrent pregnancy loss and recurrent implantation failure: prevalence and role of office hysteroscopy and immunohistochemistry in diagnosis. Fertil. Steril., 2016, vol. 105, no. 1, pp. 106–110. doi: 10.1007/s13669-017-0189-z - Cicinelli E., Matteo M., Tinelli R., Lepera A., Alfonso R., Indraccolo U., Marrocchella S., Greco P., Resta L. Prevalence of chronic endometritis in repeated unexplained implantation failure and the IVF success rate after antibiotic therapy. Hum. Reprod., 2015, vol. 30, no. 2, pp. 323–330. doi: 10.1007/978-3-319-57559-9_57

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

References (5)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK