Is the interocular choroidal structure symmetrical in healthy people? Results of symmetry studies with different partitioning methods.

Is the interocular choroidal structure symmetrical in healthy people? Results of symmetry studies with different partitioning methods. | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Is the interocular choroidal structure symmetrical in healthy people? Results of symmetry studies with different partitioning methods. Xinyue Liu, Sizhu Chen, Mengyu Li, Mingzhu Mao, Yiya Wang, Dingyang Wei, and 9 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-3978538/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Objective: To investigate the symmetry of the interocular choroidal structure in a healthy population by developing novel partitioning methods utilizing 120° ultra-wide field swept-source optical coherence tomography angiography (SS-OCTA). Methods: This cross-sectional observational study enrolled 135 healthy volunteers (270 eyes) for single 24 mm × 20 mm SS-OCTA imaging of the fundus across a 120° FOV (field of view), centered on the macula. Various partitioning methods were designed to compare the interocular symmetry of choroidal structure. Results: The interocular choroidal thickness among subjects exhibited symmetry in dichoptic, concentric circle, cruciform, and macular concentric circle + quadratic partitioning modalities. Otherwise, in the ETDRS partitioning, the mean choroidal thickness (MCT) of the right eye's upper macular epiretinal region (271.74±77.69 µm) was significantly greater than that in the left eye (263.94±75.37 µm), p = 0.019*. Furthermore, in the nine-partitioning method, the MCT of the left eye's temporal lateral region (212.44±48.41 µm) was higher than that in the right eye (208.58±46.53 µm), p = 0.048*. Conclusion: Both the observation range and partitioning methods may influence the results of interocular symmetry in choroidal structure. Utilizing contemporary population data, our study reveals that newly developed partitioning methods show symmetrical choroidal thickness across eyes. Health sciences/Health care Health sciences/Health occupations Health sciences/Medical research Full Text Additional Declarations No competing interests reported. Supplementary Files Appendix.docx Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-3978538","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":279225596,"identity":"7173f39b-ed57-4efb-8883-7821db6aad5e","order_by":0,"name":"Xinyue Liu","email":"","orcid":"","institution":"Sichuan Academy of Medical Sciences \u0026 Sichuan Provincial People's Hospital","correspondingAuthor":false,"prefix":"","firstName":"Xinyue","middleName":"","lastName":"Liu","suffix":""},{"id":279225597,"identity":"b1a5b838-7e36-47e4-a04b-e482097fc08d","order_by":1,"name":"Sizhu Chen","email":"","orcid":"","institution":"Sichuan Academy of Medical 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Results of symmetry studies with different partitioning methods.","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"","lastPublishedDoi":"10.21203/rs.3.rs-3978538/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-3978538/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eObjective: \u003c/strong\u003eTo investigate the symmetry of the interocular choroidal structure in a healthy population by developing novel partitioning methods utilizing 120° ultra-wide field swept-source optical coherence tomography angiography (SS-OCTA).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethods:\u003c/strong\u003e This cross-sectional observational study enrolled 135 healthy volunteers (270 eyes) for single 24 mm × 20 mm SS-OCTA imaging of the fundus across a 120° FOV (field of view), centered on the macula. Various partitioning methods were designed to compare the interocular symmetry of choroidal structure.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults: \u003c/strong\u003eThe interocular choroidal thickness among subjects exhibited symmetry in dichoptic, concentric circle, cruciform, and macular concentric circle + quadratic partitioning modalities. Otherwise, in the ETDRS partitioning, the mean choroidal thickness (MCT) of the right eye's upper macular epiretinal region (271.74±77.69 µm) was significantly greater than that in the left eye (263.94±75.37 µm), \u003cem\u003ep =\u003c/em\u003e 0.019*. Furthermore, in the nine-partitioning method, the MCT of the left eye's temporal lateral region (212.44±48.41 µm) was higher than that in the right eye (208.58±46.53 µm), \u003cem\u003ep\u003c/em\u003e= 0.048*.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusion: \u003c/strong\u003eBoth the observation range and partitioning methods may influence the results of interocular symmetry in choroidal structure. Utilizing contemporary population data, our study reveals that newly developed partitioning methods show symmetrical choroidal thickness across eyes.\u003c/p\u003e","manuscriptTitle":"Is the interocular choroidal structure symmetrical in healthy people? 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