The impact of quantification and distribution of prostatic calculi by computed tomography scan on lower urinary tract symptoms: a retrospective study

The impact of quantification and distribution of prostatic calculi by computed tomography scan on lower urinary tract symptoms: a retrospective study | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article The impact of quantification and distribution of prostatic calculi by computed tomography scan on lower urinary tract symptoms: a retrospective study Yoshitaka Itami, Kazuki Asada, Yuriko Hayashi, Daiki Ichii, Kota Iida, and 3 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7178078/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background: To evaluate the volume and distribution of prostatic calculi (PC) and to examine its relationship with the international prostate symptom score (IPSS), QOL score, overactive bladder symptom score (OABSS), and urinary flow test. Methods: We conducted a retrospective study of patients who visited the urology outpatient department of our hospital mainly for LUTS or medical examinations abnormalities. PC in computed tomography (CT) scans was quantified using a 3D image analysis system (VINCENT). We also evaluated whether the site of PC was periurethral or not, and distal or proximal. Results: A total of 318 patients with a mean age of 70.4 years and mean prostate volume of 44.2 ml were enrolled. CT revealed PC in 217 patients (68.2%). The IPSS, QOL score, and OABSS were significantly higher in the PC group than those in the non-PC group. PC volume showed a significant positive correlation with IPSS storage score (p=0.02). PC volume was an independent factor for IPSS storage score and OABSS in multiple regression analysis (p< 0.01). Among the PC groups, the periurethral calculi (PUC) group had significantly higher IPSS storage and OABSS than those in the non-PUC group (p=0.011 and p=0.007, respectively). Furthermore, among the PUC groups, when the calcification site was divided into proximal and distal sites, the IPSS and OABSS were significantly higher in the distal group than those in the proximal group (p=0.023 and p=0.010, respectively). Conclusions: Increased PC volume and PUC, especially at the distal site, were significantly associated with worsening urinary storage symptoms. prostatic calculi periurethral calculi calculi volume calculi distribution lower urinary tract symptoms Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7178078","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":504709388,"identity":"4ada4606-73d0-40a6-955c-00ca8d269ec0","order_by":0,"name":"Yoshitaka 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tomography scan on lower urinary tract symptoms: a retrospective study","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"prostatic calculi, periurethral calculi, calculi volume, calculi distribution, lower urinary tract symptoms","lastPublishedDoi":"10.21203/rs.3.rs-7178078/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-7178078/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eBackground: To evaluate the volume and distribution of prostatic calculi (PC) and to examine its relationship with the international prostate symptom score (IPSS), QOL score, overactive bladder symptom score (OABSS), and urinary flow test.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eMethods: We conducted a retrospective study of patients who visited the urology outpatient department of our hospital mainly for LUTS or medical examinations abnormalities. PC in computed tomography (CT) scans was quantified using a 3D image analysis system (VINCENT). We also evaluated whether the site of PC was periurethral or not, and distal or proximal.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eResults: A total of 318 patients with a mean age of 70.4 years and mean prostate volume of 44.2 ml were enrolled. CT revealed PC in 217 patients (68.2%). The IPSS, QOL score, and OABSS were significantly higher in the PC group than those in the non-PC group. PC volume showed a significant positive correlation with IPSS storage score (p=0.02). PC volume was an independent factor for IPSS storage score and OABSS in multiple regression analysis (p\u0026lt; 0.01). Among the PC groups, the periurethral calculi (PUC) group had significantly higher IPSS storage and OABSS than those in the non-PUC group (p=0.011 and p=0.007, respectively). Furthermore, among the PUC groups, when the calcification site was divided into proximal and distal sites, the IPSS and OABSS were significantly higher in the distal group than those in the proximal group (p=0.023 and p=0.010, respectively).\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eConclusions: Increased PC volume and PUC, especially at the distal site, were significantly associated with worsening urinary storage symptoms.\u003c/p\u003e","manuscriptTitle":"The impact of quantification and distribution of prostatic calculi by computed tomography scan on lower urinary tract symptoms: a retrospective study","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-08-25 03:06:59","doi":"10.21203/rs.3.rs-7178078/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"19f40f5b-828a-4745-9787-91f2c7558131","owner":[],"postedDate":"August 25th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2025-08-25T03:06:59+00:00","versionOfRecord":[],"versionCreatedAt":"2025-08-25 03:06:59","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-7178078","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-7178078","identity":"rs-7178078","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}