Health-related quality of life and psychosocial adjustment in steroid-sensitive nephrotic syndrome

Eva-Maria Rüth, Markus A. Landolt, Thomas J. Neuhaus, Markus J. Kemper
The Journal of pediatrics · 2004 · vol. 145(6) , pp. 778–783 · doi:10.1016/j.jpeds.2004.08.022 · PMID:15580200 · W1980462334
Observational OA: closed CC0
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by qwen3.7-flash, 2026-10-14 ⓘ

This study evaluated quality of life and psychosocial adjustment in children with steroid-sensitive nephrotic syndrome, finding that social functioning was impaired and influenced by treatment history and family climate.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVES: To evaluate quality of life (QOL) and psychosocial adjustment by standardized tests in well-characterized patients with steroid-sensitive nephrotic syndrome. STUDY DESIGN: Forty-five patients were investigated at a median age of 9.8 years (range, 3.4 to 19.8) and 5.9 years (range, 0.1 to 16.3) since diagnosis. Child- and parent-rated QOL was evaluated by the The Netherlands Organization for Applied Scientific Research Academical Medical Center (TNO-AZL) Child Quality of life Questionnaire. Psychosocial adjustment was assessed by the Child Behavior Checklist and the Teacher Report Form. RESULTS: In patients, only the QOL subscale "social functioning" was impaired compared with that in control subjects, whereas parents rated 4 of a total of 7 subscales as abnormal. Psychosocial adjustment was impaired at home and at school. Steroid dependency and cytotoxic treatment had a significant negative impact on QOL only, whereas family climate, especially maternal distress, negatively affected both QOL and psychosocial adjustment. CONCLUSIONS: QOL and psychosocial adjustment are impaired in steroid-sensitive nephrotic syndrome. Both illness-related variables and family climate play an important role.

My notes (saved in your browser only)

MeSH descriptors

Child Behavior Nephrotic Syndrome Quality of Life Social Adjustment Adolescent Adult Child Child, Preschool Cross-Sectional Studies Family Female Humans Male Nephrotic Syndrome Nephrotic Syndrome Nephrotic Syndrome Recurrence Surveys and Questionnaires Switzerland

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

References (45)

Source provenance

openalex
last seen: 2026-05-11T05:40:41.230350+00:00
pubmed
last seen: 2026-10-08T21:02:56.066688+00:00
unpaywall
last seen: 2026-10-18T06:28:46.490043+00:00
License: CC0 · commercial use OK