Association Between Chlamydia trachomatis and Helicobacter pylori with Inflammation in Polycystic Ovary Syndrome: A Cross-Sectionel Study

Objective: Chronic systemic inflammation has been suggested to play a role in the development of polycystic ovary syndrome (PCOS). The aim of this study was to investigate the relationship between serum Chlamydia trachomatis and Helicobacter pylori infection and inflammatory processes in patients with PCOS and healthy controls and to analyse the factors associated with PCOS. Ma¬terials and Methods: This comparative cross-sectional clinical study was conducted at Balıkesir University Hospital and included 40 female patients diagnosed with PCOS in the gynaecology and obstetrics clinic and 40 healthy female controls. Demographic data were recorded. Blood hormone profiles and biochemical parameters were analyzed. A tube of blood was taken from the PCOS and control groups and analyzed in a biochemistry tube for H. pylori IgG and Clamidydia trachomatis IgG. Enzyme-linked immunosorbent test kit was used to measure H. pylori IgG and Clamidydia trachomatis IgG. Results: Diabetes mellitus and BMI were significantly associated with PCOS (p=0.005;p=0.000). Smoking rate was significantly higher in the control group than PCOS (p=0.036). Compared with the control group; BMI, LH, HOMA-IR, CRP, TSH, TG were significantly higher in subjects with PCOS (p=004;p=00;p=001;p=043;p=000), FSH in subjects with PCOS was lower than that in the controls (p=001). There was no significant association between the PCOS and non-PCOS groups with regard to the presence of Helicobacter pylori IgG (p=0.1) and Clamidydia trachomatis IgG (p=0.338). Conclusions: Abdominal obesity, oxidative stress endothelial dysfunction and gut microbiota have been shown to cause chronic low-grade inflammation, and chronic inflammation contributes to the processes leading to the metabolic and hormonal disorders of PCOS. Whether infections contribute to polycystic ovary syndrome has not yet been sufficiently clarified. However, regardless of infections, PCOS is characterized by chronic nonspecific low-grade inflammation.