Deciphering developmental gradients in human hippocampus

Deciphering developmental gradients in human hippocampus | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Deciphering developmental gradients in human hippocampus Xi-Nian Zuo, Debin Zeng, Qiongling Li, Deyu Li, Yirong He, Xiaoxi Dong, and 23 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8009443/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract The cortical organization of human hippocampus is multidimensional, yet its developmental profile and underlying mechanisms remain largely unknown. We combined three large-scale developmental cohorts to conduct a multiscale association study and revealed a reproducible triple-gradient organization profile on the hippocampus with distinct brain-mind maturational profiles. This multidimensional organization uniquely shapes the development of cortical hierarchy, most prominently within the frontoparietal (cognitive control) and cingulo-opercular (action mode) systems. Specifically, the three gradients differentially support maturation of episodic memory and specific aspects of executive function. A progressive relaxation of geometric constraints of human hippocampus was detectable on its function over development while this mirrors regional myelination patterns related to maturation of hippocampal gradients. Further transcriptome analyses find a link between these gradient reorganization and molecular pathways underlying neurodevelopment, stress-hormone regulation, and neuroactive signaling. This multidimensional principle on hippocampal gradient organization may offer insights of its integrative growth with connectomic, geometric, myeloarchitectural, and transcriptomic factors to orchestrate the cortical hierarchy and cognitive maturation, forming a parsimonious framework for developmental neuroscience and brain health. Biological sciences/Neuroscience/Cognitive neuroscience Biological sciences/Biological techniques/Imaging/Magnetic resonance imaging Biological sciences/Neuroscience/Learning and memory/Hippocampus hippocampus action-mode brain geometry myelination BWAS Full Text Additional Declarations There is NO Competing Interest. Supplementary Files SupplementaryData1.xlsx Supplementary Data 1 SupplementaryData3.xlsx Supplementary Data 3 SupplementaryData2.xlsx Supplementary Data 2 Supplementaryinformation.docx Supplementary Information Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-8009443","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":557785280,"identity":"44d96f40-a5cc-4586-8e31-1942864771e6","order_by":0,"name":"Xi-Nian 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