Endometriosis in Reproductive Years: Fertility

In: Endometriosis and Adenomyosis · 2022 · pp. 179–186 · doi:10.1007/978-3-030-97236-3_13 · W4285111369
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Endometriosis is linked to infertility through various mechanisms including adhesions, reduced oocyte quality, and inflammation, with surgery potentially benefiting milder cases.

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This chapter reviews evidence on endometriosis in reproductive-age women and how it relates to infertility, including proposed mechanisms such as pelvic adhesions with tubal occlusion, impaired oocyte/embryo quality, altered endometrial function, inflammatory and hormonal changes. It reports that endometriosis prevalence is higher in infertile women (30–50%) than in women of reproductive age (up to 10%), and discusses that the beneficial impact of endometriosis surgery is clearer for minimal/mild disease but harder to assess in moderate/severe cases, with the presence of pain potentially affecting decisions. A major caveat emphasized is that causal mechanisms remain unclear and that evaluating surgery benefits varies by disease severity. This paper is centrally about endometriosis — it focuses on how endometriosis affects fertility and outlines use of the Endometriosis Fertility Index (EFI) in endometriosis-associated infertility, with limited discussion of broader factors like surgery timing and ART selection.

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Abstract

The prevalence of endometriosis was found to be 30–50% in infertile women compared to up to 10% in women of reproductive age, suggesting a link between endometriosis and infertility. The causal mechanisms of the impact of endometriosis on fertility are still entirely clear; however, pelvic adhesions in severe endometriosis leading to tubal occlusions, decreased oocyte and embryo quality, altered endometrium function, inflammatory changes in the peritoneal fluid, and hormonal changes may contribute to infertility. The beneficial impact of endometriosis surgery on women seeking spontaneous conception is evident for minimal/milder forms, but it is more difficult to evaluate in moderate/severe cases. Therefore, other factors such as the presence of pain may influence the decision process for surgery. Prior to considering surgery or first-line fertility treatment, a multidisciplinary assessment by specialists in both reproductive medicine and as surgery will aid the patient’s decision-making process. After surgery, the Endometriosis Fertility Index (EFI) should be used to guide future fertility management, such as the need for direct ART or not. Access this chapter Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others

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Springer, Cham. https://doi.org/10.1007/978-3-030-97236-3_13 Download citation DOI: https://doi.org/10.1007/978-3-030-97236-3_13 Published: Publisher Name: Springer, Cham Print ISBN: 978-3-030-97235-6 Online ISBN: 978-3-030-97236-3 eBook Packages: MedicineMedicine (R0)

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