Endometriosis in Reproductive Years: Fertility
Endometriosis is linked to infertility through various mechanisms including adhesions, reduced oocyte quality, and inflammation, with surgery potentially benefiting milder cases.
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This chapter reviews evidence on endometriosis in reproductive-age women and how it relates to infertility, including proposed mechanisms such as pelvic adhesions with tubal occlusion, impaired oocyte/embryo quality, altered endometrial function, inflammatory and hormonal changes. It reports that endometriosis prevalence is higher in infertile women (30–50%) than in women of reproductive age (up to 10%), and discusses that the beneficial impact of endometriosis surgery is clearer for minimal/mild disease but harder to assess in moderate/severe cases, with the presence of pain potentially affecting decisions. A major caveat emphasized is that causal mechanisms remain unclear and that evaluating surgery benefits varies by disease severity. This paper is centrally about endometriosis — it focuses on how endometriosis affects fertility and outlines use of the Endometriosis Fertility Index (EFI) in endometriosis-associated infertility, with limited discussion of broader factors like surgery timing and ART selection.
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