A study on various types of immobilization of enzyme kinetic mechanisms by comparing with the solutions obtained from AGM and MADM

A study on various types of immobilization of enzyme kinetic mechanisms by comparing with the solutions obtained from AGM and MADM | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article A study on various types of immobilization of enzyme kinetic mechanisms by comparing with the solutions obtained from AGM and MADM K. Saravanakumar, M. Veeramuni, S. Veeramani, Praveen Thomas, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4077255/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract In this article, the kinetic mechanisms are based on Michaelis-Menten reaction in presence of substrate inhibition have been solved by techniques ‘Akbari-Ganji’s Method’ (AGM) and ‘Modified Adomian decomposition method’ (MADM). Comparisons of solution of dimensionless substrate and product concentrations for various kinetic mechanisms have been carried out using AGM, MADM and numerical simulation. We assessed the impact of Thiele modulus, dimensionless inhibition degree, and concentration of substances outside the support on changing nature of substrate and product concentrations within the boundary layer in this study. The obtained results depict that the used methods have good accuracy for different values of kinetic parameters. Furthermore, the mean integrated effectiveness factor has been derived for all the mechanisms employing AGM solutions. This paper clearly illustrates the distinctions between MADM and AGM. Modified Adomian decomposition method Akbari-Ganji’s method immobilization of enzyme enzyme kinetics analytical solutions Figures Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Full Text Additional Declarations No competing interests reported. Tables 1-8 are available in the Supplementary Files section. Supplementary Files Appendices.docx Tables.docx Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4077255","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":281425293,"identity":"4127f8c5-9310-4b38-a406-b5c3747ad2b1","order_by":0,"name":"K. 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obtained from AGM and MADM","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Modified Adomian decomposition method, Akbari-Ganji’s method, immobilization of enzyme, enzyme kinetics, analytical solutions","lastPublishedDoi":"10.21203/rs.3.rs-4077255/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4077255/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eIn this article, the kinetic mechanisms are based on Michaelis-Menten reaction in presence of substrate inhibition have been solved by techniques \u0026lsquo;Akbari-Ganji\u0026rsquo;s Method\u0026rsquo; (AGM) and \u0026lsquo;Modified Adomian decomposition method\u0026rsquo; (MADM). Comparisons of solution of dimensionless substrate and product concentrations for various kinetic mechanisms have been carried out using AGM, MADM and numerical simulation. We assessed the impact of Thiele modulus, dimensionless inhibition degree, and concentration of substances outside the support on changing nature of substrate and product concentrations within the boundary layer in this study. The obtained results depict that the used methods have good accuracy for different values of kinetic parameters. Furthermore, the mean integrated effectiveness factor has been derived for all the mechanisms employing AGM solutions. This paper clearly illustrates the distinctions between MADM and AGM.\u003c/p\u003e","manuscriptTitle":"A study on various types of immobilization of enzyme kinetic mechanisms by comparing with the solutions obtained from AGM and MADM","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-03-21 13:07:15","doi":"10.21203/rs.3.rs-4077255/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"866383d3-487f-4dbd-97a8-dc60a65a9378","owner":[],"postedDate":"March 21st, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2024-03-28T11:09:56+00:00","versionOfRecord":[],"versionCreatedAt":"2024-03-21 13:07:15","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-4077255","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-4077255","identity":"rs-4077255","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}