TGFBR2High Mesenchymal Glioma Stem Cells Phenocopy Regulatory T Cells to Suppress CD4+ and CD8+ T Cell Function

2025 · doi:10.32388/70p2ux
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The paper examines a subset of mesenchymal glioma stem cells characterized by high expression of TGFBR2 and investigates how these cells influence T cell activity. Using mechanistic experiments, the authors report that the TGFBR2High glioma stem cells can phenocopy regulatory T cells, leading to suppression of CD4+ and CD8+ T cell function. A key limitation is that the study focuses on glioma-derived stem cell phenotypes and their immunomodulatory effects, so broader in vivo relevance is not established within the provided text. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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last seen: 2026-05-20T01:45:00.602351+00:00