Effects on Outcomes of Different Kinds of Endometrial Preparation Methods in Frozen Embryo Transfer Cycles During in Vitro Fertilization-Embryo Transfer

Hongbo Lin; Rong Li

doi:10.3877/cma.j.issn.1673-5250.2014.04.011

Effects on Outcomes of Different Kinds of Endometrial Preparation Methods in Frozen Embryo Transfer Cycles During in Vitro Fertilization-Embryo Transfer

Hongbo Lin, Rong Li

In: Chung-Hua Fu Ch'an K'o Tsa Chih · 2014 · vol. 10(4) , pp. 457–460 · doi:10.3877/cma.j.issn.1673-5250.2014.04.011 · W3029961545

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A retrospective analysis of 323 frozen embryo transfer cycles found no significant differences in pregnancy or abortion rates among natural, induced ovulation, and hormone replacement therapy groups after excluding patients with endometriosis and adenomyosis.

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This retrospective study analyzed 323 frozen embryo transfer cycles to compare clinical outcomes among natural, letrozole-induced ovulation, and hormone replacement therapy endometrial preparation protocols. The researchers excluded patients with specific comorbidities, including those diagnosed with endometriosis or adenomyosis, to isolate the effects of the preparation methods on infertility treatment success. Results indicated no significant differences in clinical pregnancy rates, implantation rates, or miscarriage rates across the three groups, although the natural cycle group exhibited a significantly higher rate of cycle cancellation due to non-embryonic factors. Relevance to endometriosis: listed as an exclusion criterion for participants, meaning the paper explicitly omits these conditions from its analysis of endometrial preparation efficacy.

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Abstract

Objective To investigate difference of clinical pregnancy rates, spontaneous abortion rates, cycle cancellation rates among three kinds of endometrial preparation methods during frozen embryo transfer (FET) cycles when treating infertility. Methods Retrospective analysis was conducted in 323 FET cases in Department of Reproductive Medicine,Shenzhen Hospital of Peking University from January to December, 2011. They were divided into three groups according to different kinds of endometrial preparation methods, natural cycle group(n= 89), induced ovulation cycle group(n = 110), and hormone replacement therapy (HRT) cycle group(n = 124). Exclusion criteria in this study included concurrent of hydrosalpinx, endometriosis and adenomyosis, endometrial polyps and poor ovarian reserve. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Shenzhen Hospital of Peking University. Results There had no significant differences in three groups among age,duration of infertility, body mass index,intima-medial thickness on transfer day, and the number and quality of transfer embryo (P>0.05). There had no significant differences in three groups among clinical pregnancy rates, spontaneous abortion rates, implantation rates, ectopic pregnancy rates and multiple pregnancy rates(P> 0.05). Rate of cycle cancellation (with embryo factor excluded) in natural cycle group was much higher than that in induced ovulation cycle group and HRT cycle group, respectively (P<0.05). Conclusions During FET cycle, three kinds of endometial preparation methods have their advantages and disadvantages. Therefore, further studies are needed to select the personalized endometrial preparation under individual conditions. Key words: Embryo transfer; Natural cycle; Cryotherapy; Induced ovulation cycle; Artificial cycle

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Objective

To investigate difference of clinical pregnancy rates, spontaneous abortion rates, cycle cancellation rates among three kinds of endometrial preparation methods during frozen embryo transfer (FET) cycles when treating infertility.

Methods

Retrospective analysis was conducted in 323 FET cases in Department of Reproductive Medicine,Shenzhen Hospital of Peking University from January to December, 2011. They were divided into three groups according to different kinds of endometrial preparation methods, natural cycle group(n= 89), induced ovulation cycle group(n = 110), and hormone replacement therapy (HRT) cycle group(n = 124). Exclusion criteria in this study included concurrent of hydrosalpinx, endometriosis and adenomyosis, endometrial polyps and poor ovarian reserve. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Shenzhen Hospital of Peking University.

Results

There had no significant differences in three groups among age,duration of infertility, body mass index,intima-medial thickness on transfer day, and the number and quality of transfer embryo (P>0.05). There had no significant differences in three groups among clinical pregnancy rates, spontaneous abortion rates, implantation rates, ectopic pregnancy rates and multiple pregnancy rates(P> 0.05). Rate of cycle cancellation (with embryo factor excluded) in natural cycle group was much higher than that in induced ovulation cycle group and HRT cycle group, respectively (P<0.05).

Conclusions

During FET cycle, three kinds of endometial preparation methods have their advantages and disadvantages. Therefore, further studies are needed to select the personalized endometrial preparation under individual conditions. | 1 | Pinborg A. To transfer fresh or thawed embryos? [J]. Semin Reprod Med, 2012, 30(3):230-235. | | 2 | 康艳，匡延平．冷冻周期胚胎移植周期内膜准备方案的进展[J]．生殖与避孕，2012，32(7)：478-481. | | 3 | Trouson A, Morthr L. Human pregnancy following cryopreservation, thrawing and transfer of cryopreservation, thrawing and transfer of an eight-cell st age embyo [J]. Nature, 1983, 305(7):707-709. | | 4 | 张丽珠，陈贵安，刘平，等．冻融胚胎移植临床妊娠成功[J]．中华妇产科杂志，1994，29(6)：706-707. | | 5 | Shapiro BS, Daneshmand ST, Garner FC, et al. Evidence of impaired endometrial receptivity after ovarian stimulation for in vitro fertilization: a prospective randomized trial comparing fresh and frozen-thawed embryo transfer in normal responders [J]. Fertil Steril, 2011, 96(2):344-348. | | 6 | Aflatoonian A, Oskouian H, Ahmadi S, et al. Can fresh embryo transfers be replaced by cryopreserved-thrawed embryo transfers in assisted reproductive cycles? A randomized controlled trial [J]. Assist Reprod Genet, 2010, 27(3):357-363. | | 7 | 高辉，孙正怡，邓成艳，等．人工周期法与自然周期法准备内膜在复苏囊胚移植中效果的比较[J]．生殖与避孕，2008，28(1)：54-57. | | 8 | Fatemi HM, Kyrou D, Bourgain C, et al. Cryopreserved-thawed human embryo transfer: spontaneous natural cycle is superior to human chorionic gonadotropin-induced natural cycle [J]. Fertil Steril, 2010, 94(6):2054-2058. | | 9 | Xiao Z, Zhou X, Xu W, et al. Natural cycle is superior to hormone replacement therapy cycle for vitrificated-preserved frozen-thawed embryo transfer[J]. Syst Biol Reprod Med, 2012, 58(2):107-112. | | 10 | Li SJ, Zhang YJ, Chai XS, et al. Letrozole ovulation induction: an effective option in endometrial preparation for frozen-thawed embryo transfer[J]. Arch Gynecol Obstet, 2014, 289(3):687-693. | | 11 | Zheng Y, Li Z, Xiong M, et al. Hormonal replacement treatment improves clinical pregnancy in frozen-thawed embryos transfer cycles: a retrospective cohort study[J]. Am J Transl Res, 2013, 6(1):85-90. | | 12 | Groenewoud ER, Cantineau AE, Kollen BJ, et al. What is the optimal means of preparing the endometrium in frozen-thawed embryo transfer cycles? A systematic review and Meta-analysis [J]. Hum Reprod Update, 2013, 19(5):458-470. | | [1] | 李欣, 魏艺, 张娟, 张娟娟, 凌秀凤, 赵纯, 张媔秋. 高龄女性冻胚移植周期临床妊娠结局的影响因素分析[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(03): 276-283. | | [2] | 高青卓, 康宜凡, 王治鸿. 体外受精周期中单原核胚胎的临床研究现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(03): 260-265. | | [3] | 魏丽坤, 张旭红, 罗营, 薛凤霞, 王颖梅, 宋学茹, 田丽娜, 张艳芳, 王艳霞, 田文艳. 卵巢子宫内膜异位囊肿发生恶变并发盆腔脓肿1例并文献复习[J/OL]. 中华妇幼临床医学杂志(电子版), 2023, 19(06): 696-702. | | [4] | 王丽, 王月莺, 周芬, 郭宇堃, 魏丽娜. 促性腺激素释放激素拮抗剂对子宫内膜容受性影响的研究现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2023, 19(06): 629-635. | | [5] | 顾娟, 孙擎擎, 胡方方, 曹义娟, 祁玉娟. 子宫内膜容受性检测改善胚胎反复种植失败患者妊娠结局的临床应用[J/OL]. 中华妇幼临床医学杂志(电子版), 2023, 19(05): 582-587. | | [6] | 王丁然, 迟洪滨. 自身免疫甲状腺炎对子宫内膜异位症患者胚胎移植结局的影响[J/OL]. 中华临床医师杂志(电子版), 2023, 17(06): 682-688. | | [7] | 吴利萍, 杜宁宁, 蒋静, 刘晶晶, 邢琼, 曹云霞. 自然周期冻融胚胎移植对辅助生殖技术下妊娠结局的影响[J/OL]. 中华临床医师杂志(电子版), 2023, 17(01): 54-57. | | [8] | 汪文雁, 郑剑兰, 朱丽慈. 体外受精-胚胎移植术后妊娠患者孕产期风险的临床研究[J/OL]. 中华产科急救电子杂志, 2024, 13(04): 220-226. | | [9] | 胡淼, 杜丽丽, 张丽姿, 林琳, 张瑜亮, 古士锋, 古仲嘉, 赖思莹, 梁景英, 刘雨, 黄敏珊, 黄媛媛, 黄晴晴, 罗世君, 陈敦金. 体外受精/卵胞浆内单精子注射受孕患者胎盘植入分级及围产结局的研究[J/OL]. 中华产科急救电子杂志, 2024, 13(03): 183-189. | | [10] | 刘文易, 高晓彤, 汤景, 麦卓瑶, 祝丽琼, 陈慧. 体外受精-胚胎移植妊娠合并绒毛膜下血肿患者妊娠结局的临床研究[J/OL]. 中华产科急救电子杂志, 2024, 13(02): 93-99. | | [11] | 张舒沁, 赵扬玉. 体外受精-胚胎移植与妊娠期高血压疾病[J/OL]. 中华产科急救电子杂志, 2024, 13(02): 79-83. | | [12] | 张慧婷, 冯玲. 体外受精-胚胎移植技术与早产[J/OL]. 中华产科急救电子杂志, 2024, 13(02): 73-78. | | [13] | 卫星, 孙路明. 辅助生殖技术与胎儿生长障碍[J/OL]. 中华产科急救电子杂志, 2024, 13(02): 88-92. | | [14] | 李婷, 滕银成. 体外受精-胚胎移植与前置胎盘[J/OL]. 中华产科急救电子杂志, 2024, 13(02): 84-87. | | [15] | 王山云, 张红春, 曾建峰. 切脉针刺辅助治疗体外受精-胚胎移植案例分析[J/OL]. 中华针灸电子杂志, 2024, 13(01): 24-24. | | 阅读次数 | ||||| | 全文 | | |||| | 摘要 | | |||| 版权所有中华医学会中华医学电子音像出版社有限责任公司京ICP备14006079号-1 网络出版服务许可证：(署)网出证(京)字第075号 AI 小编 AI小编

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