Relationship Between Insulin Resistance and Serum Androgens Levels in Women With and Without PCOS by Rotterdam Diagnosis Criteria

Introduction: PCOS is the most common endocrine disorder in women of childbearing age. Insulin resistance is a key component of the pathophysiology of PCOS that can increase the secretion of serum androgens. The aim of this study was to determine the relationship between insulin resistance and serum androgens levels in PCOS subgroups.MethodsHormonal and clinical laboratory studies were performed for all research units. Insulin resistance was diagnosed with the HOMA index (Cut off> 2.5). ResultsIn subgroup A, there was a positive relationship between HOMA-IR with FAI (P = 0.014) and negative relationship with SHBG (P <0.001). In subgroup C, a negative relationship was observed between HOMA-IR and SHBG (P = 0.002). In subgroup D, there was a positive relationship between HOMA-IR and FAI (P = 0.035). No significant association was found in the control group and subgroup B (P> 0.05). Also, in all different PCOS phenotypes, no association was found between HOMA-IR and serum TT levels (P> 0.05).ConclusionThere was a relationship between insulin resistance and some serum androgens in PCOS subtypes. Therefore, it is hoped that early detection of these at-risk patients will be done through early biochemical markers to prevent and change lifestyle.