Patient Treatment Journey and Burden Associated With Endometriosis: A Retrospective Claims Database Analysis

Patient Treatment Journey and Burden Associated With Endometriosis: A Retrospective Claims Database Analysis | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 14 January 2026 V1 Latest version Share on Patient Treatment Journey and Burden Associated With Endometriosis: A Retrospective Claims Database Analysis Authors : Gregory M. Christman [email protected] , Michele Cole , Kaitlyn Austin , and Cassandra Lickert Authors Info & Affiliations https://doi.org/10.22541/au.176836885.50849989/v1 124 views 60 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Objective: Present the treatment journey of women with endometriosis and associated healthcare resource utilization (HCRU) and costs. Design: Retrospective claims data analysis. Setting: January 1, 2016, to December 31, 2021, Merative™ MarketScan ® Research Database. Population: Women 18 to 55 years with ≥2 diagnosis codes for endometriosis within the study period, and ≥1 initial diagnosis code for endometriosis between January 1, 2018, and December 31, 2019 (longitudinal cohort, n=6612), or ever in 2021 (cross-sectional cohort). Methods: Data were extracted from claims and assessed descriptively. The cross-sectional endometriosis cohort (n=15,228) was compared with an age-matched control cohort without endometriosis (n=37,596). HCRU and costs were calculated on a per-patient basis averaged across the cohort for 2021. Chi-squared tests or Wilcoxon rank-sum test, without imputation or adjustment, were used to determine statistical significance between endometriosis and control cohorts. Main Outcome Measures: Treatment frequency and sequencing patterns of pharmacologic treatments and surgical procedures, HCRU, and costs. Results : The most common newly initiated treatment at diagnosis was surgery (52%). Women with endometriosis were more often also diagnosed with infertility, anxiety, and depression (all P <0.01, vs control). Correspondingly, women with endometriosis were significantly more likely to be treated with hormonal medications, and anxiolytics/antidepressants (all P <0.01, vs control), and undergo gynecologic procedures and surgeries (all P <0.01), contributing to approximately 3 times greater overall healthcare costs than women in the control cohort ($20,381 vs $7000, respectively; P <0.0001). Conclusions: Women with endometriosis experience substantial symptom burden and are most often treated with surgical procedures contributing to greater HCRU and costs. Supplementary Material File (manuscript.docx) Download 840.56 KB Information & Authors Information Version history V1 Version 1 14 January 2026 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords endometriosis: drug treatment endometriosis: surgery general gynaecology pelvic pain reproductive science: gonadotrophins Authors Affiliations Gregory M. Christman [email protected] University of Michigan View all articles by this author Michele Cole Sumitomo Pharma America Inc View all articles by this author Kaitlyn Austin Charles River Associates View all articles by this author Cassandra Lickert Sumitomo Pharma America Inc View all articles by this author Metrics & Citations Metrics Article Usage 124 views 60 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Gregory M. Christman, Michele Cole, Kaitlyn Austin, et al. Patient Treatment Journey and Burden Associated With Endometriosis: A Retrospective Claims Database Analysis. Authorea . 14 January 2026. DOI: https://doi.org/10.22541/au.176836885.50849989/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. 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