Normal and Abnormal Mitoses in the Atypical Endometrial Change Associated with Chronic Tissue Effect

Abelardo Arias-Velasquez, Javier Arias‐Stella, F. R.C. Path
In: The American Journal of Surgical Pathology · 1994 · vol. 18(7) , pp. 694–701 · doi:10.1097/00000478-199407000-00005 · PMID:8017564 · W2401491426
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-12 ⓘ

This study investigated mitoses in atypical endometrial change, finding normal mitoses in 13.4% and abnormal mitoses in 3.2%, suggesting their presence alone is insufficient for diagnosing clear-cell carcinoma.

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This study investigated the presence of normal and abnormal mitotic figures in 215 cases of florid atypical endometrial change associated with chorionic tissue effect. The authors found that mitoses occurred in 13.4% of cases, with a small subset exhibiting abnormal forms, primarily linked to early secretory type abnormalities. These observations demonstrate that mitotic activity alone is an insufficient criterion for diagnosing clear-cell carcinoma, particularly in women of reproductive age. This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

The presence of mitotic figures was investigated in 215 cases of florid atypical endometrial change associated with chorionic tissue effect. Mitoses were found in 13.4% of the cases. Mitoses were occasionally observed in 10.2% of cases, and they were multiple in single microscopic fields in 2.7%. Abnormal mitoses were noted in 3.2% of the cases. The occurrence of normal and abnormal mitoses was mainly related to the early secretory type of abnormality. These observations have biologic implications, but of more practical interest, they indicate that the presence of mitoses per se are an insufficient criteria for the diagnosis of clear-cell carcinoma, particularly in women during their reproductive period.
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High-Stage Endometrioid Carcinoma of the Ovary: PDF Only Normal and Abnormal Mitoses in the Atypical Endometrial Change Associated with Chronic Tissue Effect - Javier Arias-Stella - Abelardo Arias-Velasquez - Javier Arias-Stella - F. R.C. Path American Journal of Surgical Pathology 18(7):p 694-701, July 1994. The presence of mitotic sigures was investigated in 215 cases of florid atypical endometrial change associated with chorionic tissue effect. Mitoses were found in 13.4% of the cases. Mitoses were occasionally observed in 10.2% of cases, and they were multiple in single microscopic fields in 2.7%. Abnormal mitoses were noted in 3.2% of the cases. The occurrence of normal and abnormal mitoses was mainly related to the early secretory type of abnormality. These observations have biologic implications, but of more practical interest, they indicate that the presence of mitoses per se are an insufficient criteria for the diagnosis of clear-cell carcinoma, particularly in women during their reproductive period. Copyright © Lippincott-Raven Publishers.

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