Oral frailty is commonly observed and associated with cognitive function and decreased muscle strength in patients on maintenance hemodialysis: A retrospective observational study

Oral frailty is commonly observed and associated with cognitive function and decreased muscle strength in patients on maintenance hemodialysis: A retrospective observational study | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Oral frailty is commonly observed and associated with cognitive function and decreased muscle strength in patients on maintenance hemodialysis: A retrospective observational study Kenji Ina, Miki Tenma, Shinya Makino, Toshie Yonemochi, Miki Nagasaka, and 8 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6796402/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background Oral frailty is a new concept introduced in Japan in 2013. Our preliminary study showed that oral hypofunction was observed in more than half of patients undergoing maintenance hemodialysis (MHD). Therefore, we determined the exact prevalence of oral frailty in MHD patients and investigated the association between oral cavity function, findings obtained by comprehensive geriatric assessment, and motor features. Methods We initiated two-week hospitalization program for MHD patients to evaluate frailty including oral cavity functions. Along with a comprehensive geriatric assessment and evaluation of motor functions, seven items of oral cavity functions were assessed by a professional dentist to determine oral frailty. After determining the incidence of each item, the association between these factors was analyzed to explore the factors that affect oral frailty. Results Oral frailty was observed in 33 out of 50 patients (66%). Especially, tongue-lip motor functions were frequently impaired in this population. Oral cavity function scores, which increased as oral function deteriorated, negatively correlated with cognitive function (r = -0.349; p = 0.0129) and grip strength (r = -0.364; p = 0.00933). Conclusions Oral frailty was commonly observed in MHD patients. We are currently consider the exercise programs to improve tongue-lip motor function, enhance cognitive function through interprofessional cooperation, and strengthen the grip. Oral frailty Grip strength Locomotive syndrome Comprehensive geriatric assessment Hemodialysis Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6796402","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":466354913,"identity":"ba15814f-89a6-4631-b5fd-f93547a51014","order_by":0,"name":"Kenji 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study","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Oral frailty, Grip strength, Locomotive syndrome, Comprehensive geriatric assessment, Hemodialysis","lastPublishedDoi":"10.21203/rs.3.rs-6796402/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-6796402/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003ch2\u003eBackground\u003c/h2\u003e \u003cp\u003eOral frailty is a new concept introduced in Japan in 2013. Our preliminary study showed that oral hypofunction was observed in more than half of patients undergoing maintenance hemodialysis (MHD). Therefore, we determined the exact prevalence of oral frailty in MHD patients and investigated the association between oral cavity function, findings obtained by comprehensive geriatric assessment, and motor features.\u003c/p\u003e\u003ch2\u003eMethods\u003c/h2\u003e \u003cp\u003e We initiated two-week hospitalization program for MHD patients to evaluate frailty including oral cavity functions. Along with a comprehensive geriatric assessment and evaluation of motor functions, seven items of oral cavity functions were assessed by a professional dentist to determine oral frailty. After determining the incidence of each item, the association between these factors was analyzed to explore the factors that affect oral frailty.\u003c/p\u003e\u003ch2\u003eResults\u003c/h2\u003e \u003cp\u003eOral frailty was observed in 33 out of 50 patients (66%). Especially, tongue-lip motor functions were frequently impaired in this population. Oral cavity function scores, which increased as oral function deteriorated, negatively correlated with cognitive function (r = -0.349; \u003cem\u003ep\u003c/em\u003e\u0026thinsp;=\u0026thinsp;0.0129) and grip strength (r = -0.364; \u003cem\u003ep\u003c/em\u003e\u0026thinsp;=\u0026thinsp;0.00933).\u003c/p\u003e\u003ch2\u003eConclusions\u003c/h2\u003e \u003cp\u003e Oral frailty was commonly observed in MHD patients. We are currently consider the exercise programs to improve tongue-lip motor function, enhance cognitive function through interprofessional cooperation, and strengthen the grip.\u003c/p\u003e","manuscriptTitle":"Oral frailty is commonly observed and associated with cognitive function and decreased muscle strength in patients on maintenance hemodialysis: A retrospective observational study","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-06-06 17:19:20","doi":"10.21203/rs.3.rs-6796402/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"4d4c1582-9e6e-4738-a99d-6eaa6f5e2673","owner":[],"postedDate":"June 6th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2025-07-03T15:09:09+00:00","versionOfRecord":[],"versionCreatedAt":"2025-06-06 17:19:20","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-6796402","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-6796402","identity":"rs-6796402","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}