Updated Systematic Review on Prognostic Factors for 6-months Mortality in Older People with Dementia

Updated Systematic Review on Prognostic Factors for 6-months Mortality in Older People with Dementia | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Systematic Review Updated Systematic Review on Prognostic Factors for 6-months Mortality in Older People with Dementia Afaf Albalawi This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6595511/v2 This work is licensed under a CC BY 4.0 License Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Abstract Dementia is a progressive neurodegenerative disorder characterized by cognitive decline and functional impairment. Appropriate resource allocation and personalized care planning for individuals with dementia require the identification of prognostic indicators of impending mortality. This updated systematic review evaluated prognostic indicators of 6-month mortality among individuals with dementia. A comprehensive search of electronic databases, including PubMed, Embase, PsycINFO, and CINAHL, was conducted to identify studies published through July 31, 2024, and five studies met the inclusion criteria and were included in the systematic review. Across these studies, six-month mortality predictors were identified in four categories: nutrition-related factors (including feeding route, > 25% reduction in nutrient intake, and low albumin level), pressure injuries (including severe pressure injuries and number of pressure ulcers), oxygen use, and pneumonia-related factors (including pneumonia diagnosis and aspiration pneumonia). This review highlights factors with the potential to predict 6-month mortality among people with dementia and emphasizes the need for further research to validate these findings, standardize prognostic variable reporting, and address current data variability. dementia mortality neurodegenerative disorder personalized care planning prognostic predictors Full Text Additional Declarations The authors declare no competing interests. Cite Share Download PDF Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6595511","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Systematic Review","associatedPublications":[],"authors":[{"id":462835270,"identity":"a39b4e66-f3d0-41a1-b317-9ad44070dd15","order_by":0,"name":"Afaf Albalawi","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAABBElEQVRIie3PsUpDMRSA4RMCyRK463FpX6FZroWKz5Ig6CIFuaCCxR4oxM3ZQfQVLEJnIZAuPsDdtIuTw3UpHYqY20mQiN0c8m/nwMdJAHK5/xh/ggagb0DGwZxvdr3fiTDsBgAN8JY8A25JmPsDKRxfEIxwWEz4Gy7u/CXIyQxhvZ8kGIQmCFihFyXamUdQ4RSZO0ifeaHdVxBoyUNZbwgel8iIJ0U3yA+CT7T3Xi5rextJ972MDxsnSS8oTcyhffAqXqH2iopE+CTRQZ2QvcZKe3W2MuFox6nDqm/dPEk6QU6pWe4NO/OrR70aDYpC+mndrC/S328z3wfxY5PL5XK5rfsCA25QXMLtLYgAAAAASUVORK5CYII=","orcid":"","institution":"University of Tabuk","correspondingAuthor":true,"prefix":"","firstName":"Afaf","middleName":"","lastName":"Albalawi","suffix":""}],"badges":[],"createdAt":"2025-05-05 14:53:29","currentVersionCode":2,"declarations":{"humanSubjects":false,"vertebrateSubjects":false,"conflictsOfInterestStatement":false,"humanSubjectEthicalGuidelines":false,"humanSubjectConsent":false,"humanSubjectClinicalTrial":false,"humanSubjectCaseReport":false,"vertebrateSubjectEthicalGuidelines":false},"doi":"10.21203/rs.3.rs-6595511/v2","doiUrl":"https://doi.org/10.21203/rs.3.rs-6595511/v2","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":84253467,"identity":"73b4cdd2-a5c2-4f39-bbef-a1aa2091c219","added_by":"auto","created_at":"2025-06-09 19:17:22","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":458970,"visible":true,"origin":"","legend":"","description":"","filename":"reviewedFinalizedSystematicreviewforsubmission2.pdf","url":"https://assets-eu.researchsquare.com/files/rs-6595511/v2_covered_82515499-ffc3-4ca8-a22f-89feaf808078.pdf"}],"financialInterests":"The authors declare no competing interests.","formattedTitle":"Updated Systematic Review on Prognostic Factors for 6-months Mortality in Older People with Dementia","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"dementia, mortality, neurodegenerative disorder, personalized care planning, prognostic predictors","lastPublishedDoi":"10.21203/rs.3.rs-6595511/v2","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-6595511/v2","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e \u003cspan type=\"SmallCaps\" class=\"SmallCaps\" name=\"Emphasis\"\u003eDementia is a progressive neurodegenerative disorder characterized by cognitive decline and functional impairment. 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