Association of MUC1 5640G>A and PSCA 5057C>T polymorphisms with the Risk of Gastric Cancer in Northern Iran

Association of MUC1 5640G>A and PSCA 5057C>T polymorphisms with the Risk of Gastric Cancer in Northern Iran | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research article Association of MUC1 5 640G>A and PSCA 5057C>T polymorphisms with the Risk of Gastric Cancer in Northern Iran Reza Alikhani, Ali Taravati, Mohammad Bagher Hashemi-Soteh This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.2.24296/v3 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 13 Jul, 2020 Read the published version in BMC Medical Genetics → Version 3 posted 4 You are reading this latest preprint version Show more versions Abstract Background: Gastric cancer is the fourth most common cancer worldwide and the second leading cause of cancer-related death. Genome-Wide Association Studies (GWAS) have shown that genetic diversities MUC1 (Mucin 1) and PSCA (Prostate Stem Cell Antigen) genes are involved in gastric cancer. The aim of this study was to determine the association between rs4072037G>A polymorphism in MUC1 and rs2294008 C>T in PSCA gene with gastric cancer in northern Iran. Methods: DNA was extracted from 99 formalin fixed paraffin-embedded (FFPE) tissue samples of gastric cancer and 96 blood samples from healthy individuals (sex matched) as controls. DNA was extracted followed by PCR using specific primers. Two desired polymorphisms, 5640G>A and 5057C>T for MUC1 and PSCA genes were genotyped using PCR-RFLP method. Results: The G allele at rs4072037 of MUC1 gene was associated with a significant decreased gastric cancer risk (OR = 0.507, 95% CI: 0.322–0.799, p = 0.003). A significant decreased risk of gastric cancer was observed in people with either AG vs. AA, AG+AA vs. GG and AA+GG vs. AG genotypes of MUC1 polymorphism (OR = 4.296, 95% CI: 1.190–15.517, p = 0.026), (OR = 3.726, 95% CI: 2.033–6.830, p = 0.0001) and (OR = 0.223, 95% CI: 0.120-0.413, p = 0.0001) respectively. Overall, no significant association was observed between the PSCA 5057C>T polymorphism and risk of gastric cancer in all genetic models. Conclusion: Results indicated that the MUC1 5640G>A polymorphism may have protective effect for gastric cancer and could be considered a potential molecular marker in gastric cancer in the Northern Iran population. Medical Genetics Gastric cancer Genome-Wide Association Studies (GWAS) rs4072037G>A polymorphism rs2294008 C>T Figures Figure 1 Background Gastric cancer is the fourth most common cancer worldwide and the second leading cause of cancer-related death (1). The prevalence of gastric cancer varies among different geographic populations around the world (2). More than 70% of deaths from stomach cancer occur in developing countries (3, 4). Northern and northwestern regions of Iran are at high risk for gastric cancer (2). In addition, the mortality rate from stomach cancer is the first cause of death due to cancer in both sexes in Iran (5, 6). From 2000 to 2005, the incidence rate was highest in northern Provinces, including Mazandaran, Golestan, and Ardabil (2). It is believed that different environmental risk factors like alcohol consumption, smoking habits, diet and infectious agents (Helicobacter pylori) are involved in the development of gastric cancer (7-9), but a genetic predisposition to stomach cancer is unknown yet. Previous studies suggested an association between MUC1 and stomach (10), colon (11), lung (12), ovarian (13), breast (14), pancreas (15), and thyroid cancers (16). In addition, Genome-Wide Association Studies (GWAS) proposed genetic diversities like rs4072037G>A (5640G>A) in MUC1 gene and rs2294008C>T (5057C>T) polymorphisms in PSCA (Prostate Stem Cell Antigen) gene as genetic risk factors in gastric cancer (17). MUC1 (Mucin 1) gene is located on chromosome 1q21 and includes seven exons (18). This gene encodes a membrane-bound glycoprotein with the transmembrane domain, which is attached to the upper surface of the gastrointestinal epithelium. It plays important roles in protecting epithelial surfaces against external agents (19, 20). MUC1 protein in tumor cells or tumor-associated MUC1 (TA-MUC1) differs from MUC1 expressed in normal cells, with regard to its cellular distribution, biochemical features, and function. TA-MUC1 is hypoglycosylated and overexpressed in a variety of cancers, which plays a crucial role in progression of the disease (21). It is believed that hypoglycosylation may potentiate MUC1 oncogenic signaling by decreasing its cell surface levels and increasing intracellular accumulation (21, 22). PSCA gene is located on chromosome 8q24.3, which encodes a glycosylphosphatidyl inositol (GPI)-anchored protein with 114 amino acids. PSCA gene plays an important role in cell adhesion, proliferation, and survival (23, 24). PSCA is expressed in the epithelial cells of the bladder, stomach, kidney, skin, and esophagus. The function of PSCA in normal cells and carcinogenesis is not clearly known (25). Several reports indicated that PSCA is associated with various cancers, such as prostate (26), bladder (27), and pancreatic cancer (28). PSCA is up-regulated in the prostate, and pancreas cancers, while in the esophagus and stomach cancers it is down-regulated (29). 5057C>T is a missense single nucleotide polymorphism (SNP) in 5'-UTR region of PSCA . This polymorphism leads to changes in transcriptional activity in the upstream regions of PSCA gene (30). The C allele changes the initiation codon from ATG to the alternative start codon ACG (threonine instead of methionine) and leads to a truncated protein lacking nine amino acids from the N-terminus of PSCA protein. This alteration changes the protein folding and impairs intracellular processes (31). The aim of this study is also evaluating the association between MUC1 gene polymorphism, rs4072037G>A and PSCA gene polymorphism rs2294008C>T with gastric cancer in northern Iran. Methods The study population Ninety nine formalin fixed paraffin-embedded (FFPE) tissue samples (64 males and 35 females, average age 67.5 ±10.9) were collected from gastric cancer patients who referred to the pathology department of the Sari Imam Khomeini hospital from 2009 to 2016 (Table 1) (Mazandaran Province). Tumor characteristics of the patients are summarized in table 2. In addition, 96 blood samples were collected as control from healthy individuals (57 males and 39 females, average age 34.3 ±7.0) who referred to Novin genetics laboratory of Sari for other reasons except gastric diseases (Table 1). The normal control individuals were not age-matched with patients, but they were selected randomly to find the allele/genotype frequency of the polymorphisms in the local population. Blood samples were collected in EDTA containing tubes and preserved at -20 °C. This research was approved by the ethics committee in the Mazandaran University of Medical Sciences. DNA extraction DNA was extracted from paraffin-embedded tissues using “YTA Genomic DNA Extraction mini kit (Yekta Tajhiz Azma, Iran) and standard salting out methods from blood samples, respectively. The extracted DNA was maintained at -20 ° C until further study. Genotyping using PCR-RFLP method PCR ( Polymerase chain reaction ) was applied to amplify exon 2 of MUC1 and 5'-UTR region of PSCA genes, including desired polymorphisms using specific primers (Table 3). Each reaction consists of 2μl template DNA, 11μl ready 2x PCR master mix RED (Ampliqon, Denmark), 11μl distilled water, 0.5μl of each primer at 25μM, in a total volume of 25μl. The PCR reactions were carried out under the following conditions: 94ºC for 5 minutes, followed by 35 cycles 94ºC for 60 seconds; 72ºC for 60 seconds. The annealing temperature of 60 ºC for 60 seconds was used for MUC1 gene and 56 ºC for 60 seconds used for PSCA gene. PCR products were visualized on 1% agarose gel containing SYBR Safe staining. Then, PCR products were subjected to restriction digestion using 6μl of the PCR products and five units of restriction enzyme. Briefly, 188 bp PCR fragment of the MUC1 gene was digested using AIWNI enzyme; a homozygous GG allele remained uncut, homozygous AA genotype was digested into 114 and 74 bp fragments, and heterozygous GA produced three fragments, 118, 114 and 74 bp, respectively (Figure 1, A). Also, 139 bp PCR fragment of the PSCA gene was digested using a NIaIII restriction enzyme, genotype TT was digested to 2 fragments, 101 and 38 bp, genotype CC remained uncut and heterozygous CT showed three fragments, 139, 101 and 38 bp, respectively (Figure 1, B). Statistical analysis Chi-square test was used to evaluate differences in the distributions of demographic characteristics. The expected frequency of control genotypes was tested against the Hardy–Weinberg equilibrium. The odds ratio (OR) and 95% confidence interval (CI) were calculated using a logistic regression model. A p -value < 0.05 was considered statistically significant. Otherwise, the pooled ORs and 95% CIs without adjustments were calculated for the MUC1 polymorphism rs4074037 as allele (G vs . A), homozygous genotype (GG vs . AA), heterozygous (AG vs . AA), dominant (AG+AA vs. GG), recessive (AA vs. AG+GG) and over-dominant model (AA+GG vs. AG). For PSCA polymorphism rs2294008, it was considered as allele (T vs . C), homozygous (TT vs . CC), heterozygous (CT vs . CC), dominant (CT+CC vs. TT), recessive (CC vs. CT+TT). The statistical analysis was performed using the IBM SPSS Statistics v21 software package (SPSS, Chicago, IL, USA). Results Demographic and clinical information of 99 patients with gastric cancer and 96 controls are shown in tables 1 and 2, respectively. Ninety nine patient samples were genotyped for PSCA gene (rs2294008) and 91 patient samples for MUC1 gene (rs4072037) polymorphism. Genotype and allele frequencies of rs4072037 and rs2294008 and their associations with the risk of gastric cancer are presented in tables 4 and 5, respectively. The G allele frequency of rs4072037 is 64% in patients with gastric cancer compared with 78% in controls, respectively (Table 4). MUC1 rs4072037 polymorphism is associated with significant decreased gastric cancer risk in four genetic models: G vs. A (OR = 0.507, 95% CI: 0.322–0.799, p = 0.003); heterozygous AG compared with AA (OR = 4.296, 95% CI: 1.190–15.517, p = 0.026); dominant model AG+AA vs. GG (OR = 3.726, 95% CI: 2.033–6.830, p = 0.0001); and over-dominant model AA+GG vs . G (OR = 0.223, 95% CI: 0.120-0.413, p = 0.0001) (Table 4). In the current study, no significant association was observed between the PSCA 5057C>T polymorphism and risk of gastric cancer in all genetic models (T vs. C (OR = 1.050, 95% CI: 0.652 –1.693, p = 0.840); homozygous TT vs. CC (OR = 0.903, 95% CI: 0.327 –2.492, p = 0.533); heterozygous CT vs. CC (OR = 1.228, 95% CI: 0.644 –2.339, p = 0.533); dominant model CT+CC vs. TT (OR = 1.137, 95% CI: 0.420 –3.080, p = 0.800); and recessive model CC vs. CT+TT (OR = 0.904, 95% CI: 0.505 –1.620, p = 0.735)). As a result, There was no statistically significant differences between the genotype and allele frequency of PSCA (5057C>T) in cases and controls in this study (Table 5). Furthermore, the result of interaction effects between MUC1 (rs4072037) and PSCA (rs2294008) genotypes with gender is summarized in table 6. Discussion Different studies revealed a decreased incidences of gastric cancer globally, but it is still the most common cancer in the north and northwestern parts of Iran (2). Mazandaran, Golestan, and Ardabil Provinces are high-risk for gastric cancer (2, 32). Gastric cancer is a multi-factorial disease; a high dietary intake of salt, the high prevalence of Helicobacter pylori ( H. pylori ) infection, smoking and gastroesophageal reflux disease are the environmental factors in the pathogenesis of this disease in Iran (2, 9). Among genetic risk factors, MUC1 (5640G>A) and PSCA (5057C>T) polymorphisms were reported in several studies earlier (33-36). MUC1 is a large, transmembrane mucin glycoprotein expressed at the apical surface of most simple epithelia including stomach. Functions related to MUC1 are generally associated with mucins such as lubrication, hydration of cell surfaces, protection from microorganisms and degradative enzymes (37). MUC1 protein contains three different domains: short cytoplasmic, transmembrane and a large extracellular domain. The MUC1 gene in human is comprised of 7 exons that can be alternatively spliced to form different transcripts (37). At least twelve splice variants of MUC1 have been described (38). The SNP rs4072037G>A (5640G>A) located in the 5' side of the second exon determines the splicing acceptor site and produce two major MUC1 transcripts. The “G” allele determines the variant type 2 or MUC1/B and contains the first 27 bp of the 2nd exon and have 9 amino acids longer than “A” allele, which create variant type 3 or MUC1/A in the N-terminal domain (39-41). This additional sequence is potentially changing its intracellular trafficking or subsequent processing. The impact of the nine additional amino acids of MUC1/A on the signaling functions and intracellular localization was investigated by Imbert-Fernandez and colleagues (41). They showed that COS-7 cell line transfected by plasmid containing MUC1/A or MUC1/B had similar protein expression and plasma membrane localization. This study also showed MUC1/B and MUC1/A differs in their ability to modulate tumor necrosis α (TNFα)-induced transcription of IL-1β and IL-8, inducing the basal TGFβ expression; finally they show different inflammatory activities (41). MUC1 could protect the gastric epithelial cells as physical barriers, so could inhibit H. pylori binding to gastric epithelial cells. The carriers of the short-short (SS) homozygous variant genotype, were at a high risk of H. pylori infection, compared to the carriers of the long-long (LL) and long-short (LS) genotypes of MUC1 variable number of tandem repeats ( VNTR ) (42). Miao Li and colleagues, examined the relation between H. pylori infection and three polymorphisms (rs4072037 at 1q22, rs13361707 at 5p13, and rs2274223 at 10q23) involved in the inflammatory response to the increase of gastric cancer risk. They reported that people infected by H. pylori, carrying the genotypes AA rs4072037, CT/CC rs13361707 and AG/GG rs2274223 showed an increased risk of gastric cancer(43). Different studies ( Hanze Zhang et al., 2011, J Kupcinskas et al., 2014) have shown that the G allele locus on rs4072037 was significantly associated with a decreased gastric cancer risk (44, 45). Xinyang Liu et al ., 2014 suggested the G allele at rs4072037 of the MUC1 gene might have a protective rule in people from Asian countries against gastric cancer. Also, they reported that the association was more prevalent in Asian population than in Caucasians (46). In this study, allelic comparison (G vs. A), genotype comparison (GA vs. AA; GG vs. AA), were done and dominant model (AG+AA vs. GG), recessive model (AA vs. AG+GG), over-dominant model (AA+GG vs. AG) was tested (47). We found that in this study, the rs4072037 AG genotype was significantly associated with the reduced risk of gastric cancer or it plays a protecting role [odds ratios (OR) = 4.296; 95% confidence interval (CI) = 1.190-15.517, p = 0.026 for AG vs. AA]. A study by Hye-Rim Song et al. , 2014, with 3,245 GC cases and 700 controls suggests that the rs4072037 AG genotype was significantly associated with a reduced risk of gastric cancer [odds ratios (OR) = 0.78; 95 % confidence interval (CI) = 0.67–0.91 for AG vs. AA]. Their data indicated a significant association between the rs4072037 G allele and reduction in risk of gastric cancer (48). Another meta-analysis by Xi Gu et al ., 2018, which included seventeen case–control studies (12551 cases and 13436 controls), suggests that the MUC1 rs4072037 polymorphism might decrease the risk of gastric cancer in four different genetic combination (G vs. A; AG vs. AA; GG vs. AA; AG+GG vs. AA). They also performed analysis using ethnicity along with G allele and found the cancer risk was decreased among Asian population but not Caucasian (49). Similar results (including 4,220 cases and 6,384 controls) have been obtained by Duan et al , 2014 through evaluating the association between MUC1 (rs4072037) polymorphism and gastric cancer (50). Their study demonstrated that the MUC1 (rs4072037) polymorphism is associated with risk of cancer in all genetic models (G vs. A; GA vs. AA; GG vs. AA; AG+AA vs. GG; GG vs. AG+AA). They suggested MUC1 (rs4072037) polymorphism had a slightly reduced gastric cancer risk among Asian population. Also, this polymorphism was significantly associated with a decreased cancer risk in all genetic models except for homozygous recessive (AA) model in Caucasian population (50). In this study, MUC1 rs4072037 polymorphism was significantly associated with a decreased risk of cancer in all genetic models except for homozygous GG vs. AA and recessive model AG+GG vs. AA (G vs. A: OR = 0.507, 95% CI: 0.322–0.799, p = 0.003; AG vs. AA: OR = 4.296, 95% CI: 1.190–15.517, p = 0.026; AG+AA vs. GG: OR = 3.726, 95%CI: 2.033–6.830, p = 0.0001; AA+GG vs. AG: (OR = 0.223, 95% CI: 0.120-0.413, p = 0.0001)). Data from this case-control study indicated that four genetic models G vs. A, heterozygous GA (GA vs. AA), dominant (AG+AA vs. GG), over-dominant model (AA+GG vs. AG), were significantly associated with the decreased risk of cancer. Therefore, MUC1 rs4072037 polymorphism was associated with decreased risk of gastric cancer in northern Iran. The Prostate Stem Cell Antigen ( PSCA ) is expressed in the gastric epithelium of the isthmus area. This area includes immature epithelial cells. PSCA expression increases in prostate cancer but it is reduced in gastric cancer and gastric intestinal metaplasia (51, 52). T allele carriers show lower transcriptional activity compared with the C allele carriers (5057C>T) in their gastric mucosa (31, 51). T allele carriers have nine amino acids more than C allele carriers (natural protein of 114 amino acid residues) (53). The association of PSCA (5057C>T) variant was described in Korea and Japan population for the first time and the T allele was reported as a risk factor for gastric cancer (31). A study in Japan and Korea showed that 5057T allele plays a more significant role in diffuse gastric cancer compared with the intestinal gastric cancer (31, 54). Such results were also similar in the population of Poland and the United States (34). Other studies in Caucasian and Chinese population also confirmed that this polymorphism is a risk factor for diffuse and intestinal gastric cancer (55). In this study, PSCA rs2294008 polymorphism was not significantly associated with an increased risk of cancer in all genetic models (T vs. C (OR = 1.050, 95% CI: 0.652 –1.693, p = 0.840); homozygous TT vs. CC (OR = 0.903, 95% CI: 0.327 –2.492, p = 0.533); heterozygous CT vs. CC (OR = 1.228, 95% CI: 0.644 –2.339, p = 0.533); dominant model CT+CC vs. TT (OR = 1.137, 95% CI: 0.420 –3.080, p = 0.800); and recessive model CC vs. CT+TT (OR = 0.904, 95% CI: 0.505 –1.620, p = 0.735) (Table 5). Therefore, PSCA rs2294008 polymorphism was not associated with increased risk of gastric cancer in Northern Iran. Conclusion In conclusion, this study evaluated the effect of MUC1 (rs4072037) and PSCA (rs2294008) polymorphisms on GC risk in the Northern Iran population. Data from this study revealed that the MUC1 rs4072037 polymorphism was significantly associated with decreased risk of gastric cancer. However, the results could be important, especially for the interpretation of a genetic variant, which cause susceptibility to gastric cancer, and could be used as diagnostic markers in gastric cancer. In addition, PSCA polymorphism did not show any relation to gastric cancer in our findings probably because of the type of gastric cancer or the small sample size. Declarations Ethics approval and consent to participate This study was approved by the Ethical Committee of Mazandaran University of Medical Sciences and complied with the guidelines and principles of the Declaration. All participants signed written informed consent. Consent for publication All participants signed written informed consent for publication. Availability of data and material The datasets used and/or analyzed during the current study are available from the author for correspondence upon reasonable request. Competing interests The authors declare that they have no competing interests. Funding This work was supported by Mazandaran University of Medical Sciences. Authors' contributions Mohammad bagherHashemi-soteh conceived and designed the study. Reza Alikhani performed the experiments. Ali Taravati analyzed the data. Mohammad bagherHashemi-soteh and Reza Aikhani wrote and edited the manuscript. All authors read and approved the final manuscript. Acknowledgements We would like to thank Mazandaran University of Medical Sciences for its financial support, and all the volunteers who participated in this study. Abbreviations GWAS: Genome-Wide Association Studies MUC1: Mucin 1 PSCA: Prostate Stem Cell Antigen FFPE: Formalin fixed paraffin-embedded TA-MUC1: tumor-associated MUC1 GPI: Glycosylphosphatidyl inositol SNP: Single nucleotide polymorphism PCR: Polymerase chain reaction RFLP: Restriction fragment length polymorphism H. pylori : Helicobacter pylori References Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. 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Genetic variants at 1q22 and 10q23 reproducibly associated with gastric cancer susceptibility in a Chinese population. Carcinogenesis. 2011;32(6):848-52. Kupcinskas J, Wex T, Link A, Bartuseviciute R, Dedelaite M, Kevalaite G, et al. PSCA and MUC1 gene polymorphisms are linked with gastric cancer and pre-malignant gastric conditions. Anticancer research. 2014;34(12):7167-75. Liu X, Wang Z, Zhang X, Chang J, Tang W, Gan L, et al. MUC1 gene polymorphism rs4072037 and susceptibility to gastric cancer: a meta-analysis. Springerplus. 2014;3(1):599. Horita N, Kaneko T. Genetic model selection for a case–control study and a meta-analysis. Meta gene. 2015;5:1-8. Song H-R, Kim HN, Kweon S-S, Choi J-S, Shim HJ, Cho SH, et al. Common genetic variants at 1q22 and 10q23 and gastric cancer susceptibility in a Korean population. Tumor Biology. 2014;35(4):3133-7. Gu X, Feng J, Liu L, Lu M, Ma X, Cao Y, et al. Association of MUC1 rs4072037 Functional Polymorphism and Cancer Risk: Evidence from 12551 Cases and 13436 Controls. Journal of Cancer. 2018;9(18):3343. Duan F, Song C, Dai L, Cui S, Zhang X, Zhao X. The effect of MUC1 rs4072037 functional polymorphism on cancer susceptibility: evidence from published studies. PloS one. 2014;9(4):e95651. Toyoshima O, Tanikawa C, Yamamoto R, Watanabe H, Yamashita H, Sakitani K, et al. Decrease in PSCA expression caused by Helicobacter pylori infection may promote progression to severe gastritis. Oncotarget. 2018;9(3):3936-45. Gu Z, Thomas G, Yamashiro J, Shintaku IP, Dorey F, Raitano A, et al. Prostate stem cell antigen (PSCA) expression increases with high gleason score, advanced stage and bone metastasis in prostate cancer. Oncogene. 2000;19(10):1288-96. Tanikawa C, Urabe Y, Matsuo K, Kubo M, Takahashi A, Ito H, et al. A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population. Nat Genet. 2012;44(4):430-4, S1-2. Matsuo K, Tajima K, Suzuki T, Kawase T, Watanabe M, Shitara K, et al. Association of prostate stem cell antigen gene polymorphisms with the risk of stomach cancer in Japanese. Int J Cancer. 2009;125(8):1961-4. Lu Y, Chen J, Ding Y, Jin G, Wu J, Huang H, et al. Genetic variation of PSCA gene is associated with the risk of both diffuse- and intestinal-type gastric cancer in a Chinese population. Int J Cancer. 2010;127(9):2183-9. Tables Table 1: Demographic characteristics of the cases and controls. Variables Cases (n = 99) Controls (n = 96) P Age (years) (mean ± SD) 67.5 ± 10.9 34.3 ± 7 0.000 Sex n % n % Male 64 52.9 57 47.1 0.448 Female 35 47.3 39 52.7 Table 2. Tumor characteristics, including tumor site, tumor grade, lymphatic invasion, perineural invasion, tumor stage and tumor type. Characteristic Frequency (%) Tumor site Cardia 18 (33.3) Fundus 0 (0.0) Body 11 (20.4) Antrum 18 (33.3) overlapping 7 (13.0) Total 54(100) Grade I 13 (18.8) II 39 (56.5) III 17 (24.6) Total 69(100) Lymphatic invasion Present 27 (67.5) Absent 13 (32.5) Total 40(100) Perineural invasion Present 28 (54.9) Absent 23 (45.1) Total 51(100) T 1 3 (6.1) 2 19 (38.8) 3 26 (53.1) 4 1 (2.0) Total 49(100) N 0 19 (36.6) 1 18 (37.5) 2 9 (118.8) 3 2 (4.2) Total 48(100) M 0 6 (66.7) 1 3 (33.3) Total 9(100) Stage I 8 (19.0) II 16 (38.1) III 15 (35.7) IV 3 (7.1) Total 42(100) Tumor type Diffuse 14 (73.7) Intestinal 5 (26.3) Total 19(100) Table 3. Primer sequences, PCR size and PCR-RFLP fragments using AIWNI and NIaIII restriction enzymes for MUC1 5640G>A (rs4072037) and PSCA 5057C>T (rs2294008) polymorphisms, respectively. SNP Primer sequence PCR Size (bp) Restriction enzyme Digestion products (bp) Wild-type Mutant Heterozygous MUC1 5640G>A (rs4072037) F: TAAAGACCCAACCCTATGACT 188 AIWNI 188 114,74 188,114,74 R: AGAGTACGCTGCTGGTCATACTC PSCA 5057C>T (rs2294008 F: GAAACCCGCTGGTGTTGACT 139 NIaIII 139 101,38 139,101,38 R: GCCAAGCCTGCCATCAACAG Table 4. Comparison of genotype and allele frequencies of MUC1 gene polymorphisms between gastric cancer patients (n=91) and normal controls (n=96) using chi-square analysis. SNP a Genotype/Allele Controls(n=96) Cases(n=91) OR b (95% CI c ) P -value MUC1 d 5640G>A (rs4072037) AA 8 (8.4%) 4 (4.1%) - - AG 27 (28.1%) 58 (63.9%) 4.296 (1.190-15.517) 0.026 GG 61 (63.5%) 29 (32%) 0.951 (0.265-3.417) 0.938 AG+GG 88 (91.6%) 87 (95.9%) 0.506 (0.147-1.741) 0.280 AG+AA 35 (36.5%) 62 (68%) 3.726 (2.033-6.830) 0.0001 AA+GG 69 (71.9%) 33 (36.1%) 0.223 (0.120-0.413) 0.0001 A 43 (22%) 66 (36%) - - G 149 (78%) 116 (64%) 0.507 (0.322 - 0.799) 0.003 a. Single nucleotide polymorphisms, b. odds ratio, c. confidence interval, d. Mucin 1 Table 5. Comparison of genotype and allele frequencies of PSCA* gene polymorphisms between gastric cancer patients (n= 99) and normal controls (n= 96) using chi-square analysis. SNP a Genotype/Allele Controls(n=96) Cases(n=99) OR b (95% CI c ) P -value PSCA d 5057C>T (rs2294008 CC 63 (65.6%) 62 (62.6%) - - CT 24 (25%) 29 (29.3%) 1.228 (0.644 - 2.339) 0.533 TT 9 (9.4%) 8 (8.1%) 0.903 (0.372 -2.492) 0.844 CT+TT 34 (34.4%) 37 (37.4%) 0.904(0.505-1.620) 0.735 CT+CC 90 (90.6%) 91 (91.9%) 1.137(0.420-3.080) 0.800 C 150 (78%) 153 (77%) - - T 42 (22%) 45 (23%) 1.050 (0.652 - 1.693) 0.840 a. Single nucleotide polymorphisms, b. odds ratio, c. confidence interval,* Prostate stem cell antigen Table 6. D istribution of genotypes MUC1 ( rs4072037) and PSCA (rs2294008) polymorphisms according to Sex . Sex Group MUC1 5640G>A ( rs4072037) p -value PSCA 5057C>T (rs2294008) p -value GG GA AA CC CT TT Male Case 18(30.5%) 40(67.8%) 1(1.7%) 0.0001 41(64.1%) 17(26.6%) 6(9.4%) 0.92 Control 35(61.4%) 17(28.9%) 5(8.8%) 35(61.4%) 17(29.8%) 5(8.8%) Female Case 11(34.4%) 18(56.3%) 3(9.4%) 0.06 21(60.0%) 12(34.3%) 2(5.7%) 0.25 Control 24(61.5%) 12(30.8%) 3(7.7%) 28(71.8%) 7(17.9%) 4(10.3%) Cite Share Download PDF Status: Published Journal Publication published 13 Jul, 2020 Read the published version in BMC Medical Genetics → Version 3 posted Editor assigned by journal 15 Jun, 2020 Editorial decision: Minor revision 15 Jun, 2020 Submission checks completed at journal 14 Jun, 2020 Editor invited by journal 14 Jun, 2020 You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-14855","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research article","associatedPublications":[],"authors":[{"id":670004,"identity":"85f8891f-6d1f-44ae-829b-fb501442b969","order_by":0,"name":"Reza Alikhani","email":"","orcid":"","institution":"Molecular and Cell Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Mazandaran, Iran","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Reza","middleName":"","lastName":"Alikhani","suffix":""},{"id":670005,"identity":"95a8b8f6-2de6-46f4-8773-4ac820257fec","order_by":1,"name":"Ali Taravati","email":"","orcid":"","institution":"Assistant Professor, Department of Molecular and Cell Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar. Mazandaran, Iran","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Ali","middleName":"","lastName":"Taravati","suffix":""},{"id":670006,"identity":"853fc08b-127c-45dc-9a14-8b80eb9c48f0","order_by":2,"name":"Mohammad Bagher Hashemi-Soteh","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA8UlEQVRIiWNgGAWjYBACAwYGNiAlAWKzMXwAkexEa2FjYGOcAdLCTJwWsB1szDwgBiEt5uzHnz34mGNhzy/ffOyxza9t8nzMDIwfPubg1mLZk2NuOHObROLMNrZ049y+24ZtzAzMkjO34XHYgRw2ad5tEgkGx3jMpHN7bjMCtbAx8+LTcv75M+m/2yTsDY7xf5O27LltT1jLjQQzacZtEowbjvGwSTP8uJ1IhJY3ZpK9YL+kARkNt5PbmBmb8fvlfPoziZ/b6uz5mQ8/k/jx57bt/Pbmgx8+4tGCChjbwGQDsepB4A8pikfBKBgFo2CkAAADT0uMuaa3jwAAAABJRU5ErkJggg==","orcid":"https://orcid.org/0000-0001-5361-520X","institution":"Immunogenetic Research Center, Molecular and Biology Research Center, Medical Faculty, Mazandaran University of Medical, Sari, mazandaran, Iran","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Mohammad","middleName":"Bagher","lastName":"Hashemi-Soteh","suffix":""}],"badges":[],"createdAt":"2020-02-21 11:58:53","currentVersionCode":3,"declarations":"","doi":"10.21203/rs.2.24296/v3","doiUrl":"https://doi.org/10.21203/rs.2.24296/v3","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1186/s12881-020-01085-z","type":"published","date":"2020-07-13T12:00:00+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":1346466,"identity":"15e55359-6691-40fe-bca0-9c9d04aef716","added_by":"auto","created_at":"2020-06-16 23:40:52","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":353423,"visible":true,"origin":"","legend":"3% agarose gel electrophoresis of the restriction enzyme digestion (A) 188 bp PCR fragment of the MUC1 gene restriction enzyme digestion results using AIWNI enzyme; lane 1 and 3 shows homozygous AA, lane 2 heterozygous GA genotype and lane 4 shows homozygous GG genotype respectively, lane 5 shows 100 bp DNA marker (B) Restriction enzyme map of the 139 bp PCR fragment of the PSCA gene using NIaIII enzyme. Lane 1= 100 bp DNA marker, lane 2 heterozygous CT, lane 3 (101 and 39 bp) shows homozygous TT and lane 4, uncut PCR product shows homozygous CC genotype respectively.","description":"","filename":"fig1.PNG","url":"https://assets-eu.researchsquare.com/files/rs-14855/v3/fig1.PNG"},{"id":15667480,"identity":"ddd70983-87c0-4b74-9182-c4a45dc7332e","added_by":"auto","created_at":"2021-11-18 13:42:18","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":746531,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-14855/v3/18ffbfc0-5852-4849-9186-b2973ab845f5.pdf"}],"financialInterests":"","formattedTitle":"\u003cp\u003eAssociation of \u003cem\u003eMUC1 5\u003c/em\u003e640G\u0026gt;A and \u003cem\u003ePSCA \u003c/em\u003e5057C\u0026gt;T polymorphisms with the Risk of Gastric Cancer in Northern Iran\u003c/p\u003e","fulltext":[{"header":"Background","content":"\u003cp\u003eGastric cancer is the fourth most common cancer worldwide and the second leading cause of cancer-related death (1). The prevalence of gastric cancer varies among different geographic populations around the world (2). More than 70% of deaths from stomach cancer occur in developing countries (3, 4). Northern and northwestern regions of Iran are at high risk for gastric cancer (2). In addition, the mortality rate from stomach cancer is the first cause of death due to cancer in both sexes in Iran (5, 6). From 2000 to 2005, the incidence rate was highest in northern Provinces, including Mazandaran, \u0026nbsp;Golestan, and Ardabil (2). It is believed that different environmental risk factors like alcohol consumption, smoking habits, diet and infectious agents (Helicobacter pylori) are involved in the development of gastric cancer (7-9), but a genetic predisposition to stomach cancer is unknown yet. Previous studies suggested an association between \u003cem\u003eMUC1\u003c/em\u003e and stomach (10), colon (11), lung (12), ovarian (13), breast (14), pancreas (15), and thyroid cancers (16). In addition, Genome-Wide Association Studies (GWAS) proposed genetic diversities like rs4072037G\u0026gt;A (5640G\u0026gt;A) in \u003cem\u003eMUC1\u003c/em\u003e gene and rs2294008C\u0026gt;T (5057C\u0026gt;T) polymorphisms in \u003cem\u003ePSCA \u003c/em\u003e(Prostate Stem Cell Antigen) gene as genetic risk factors in gastric cancer (17).\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eMUC1 \u003c/em\u003e(Mucin 1) gene is located on chromosome 1q21 and includes seven exons (18). This gene encodes a membrane-bound glycoprotein with the transmembrane domain, which is attached to the upper surface of the gastrointestinal epithelium. It plays important roles in protecting epithelial surfaces against external agents (19, 20). MUC1 protein in tumor cells or tumor-associated MUC1 (TA-MUC1) differs from MUC1 expressed in normal cells, with regard to its cellular distribution, biochemical features, and function. TA-MUC1 is hypoglycosylated and overexpressed in a variety of cancers, which plays a crucial role in progression of the disease (21). It is believed that hypoglycosylation may potentiate \u003cem\u003eMUC1\u003c/em\u003e oncogenic signaling by decreasing its cell surface levels and increasing intracellular accumulation (21, 22).\u003c/p\u003e\n\u003cp\u003e\u003cem\u003ePSCA \u003c/em\u003egene is located on chromosome 8q24.3, which encodes a glycosylphosphatidyl inositol (GPI)-anchored protein with 114 amino acids. \u003cem\u003ePSCA\u003c/em\u003e gene plays an important role in cell adhesion, proliferation, and survival (23, 24). PSCA is expressed in the epithelial cells of the bladder, stomach, kidney, skin, and esophagus. The function of PSCA in normal cells and carcinogenesis is not clearly known (25). Several reports indicated that \u003cem\u003ePSCA\u003c/em\u003e is associated with various cancers, such as prostate (26), bladder (27), and pancreatic cancer (28). \u003cem\u003ePSCA \u003c/em\u003eis up-regulated in the prostate, and pancreas cancers, while in the esophagus and stomach cancers it is down-regulated (29). 5057C\u0026gt;T is a missense single nucleotide polymorphism (SNP) in 5'-UTR region of \u003cem\u003ePSCA\u003c/em\u003e. This polymorphism leads to changes in transcriptional activity in the upstream regions of \u003cem\u003ePSCA \u003c/em\u003egene (30). The C allele changes the initiation codon from ATG to the alternative start codon ACG (threonine instead of methionine) and leads to a truncated protein lacking nine amino acids from the N-terminus of PSCA protein. This alteration changes the protein folding and impairs intracellular processes (31).\u003c/p\u003e\n\u003cp\u003eThe aim of this study is also evaluating the association between \u003cem\u003eMUC1\u003c/em\u003e gene polymorphism, rs4072037G\u0026gt;A and \u003cem\u003ePSCA\u003c/em\u003e gene polymorphism rs2294008C\u0026gt;T with gastric cancer in northern Iran.\u003c/p\u003e"},{"header":"Methods","content":"\u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eThe study population\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNinety nine formalin fixed paraffin-embedded (FFPE) tissue samples (64 males and 35 females, average\u0026nbsp;\u003cem\u003eage \u003c/em\u003e67.5 \u0026plusmn;10.9) were collected from gastric cancer patients who referred to the pathology department of the Sari Imam Khomeini hospital from 2009 to 2016 (Table 1) (Mazandaran Province). Tumor characteristics of the patients are summarized in table 2. In addition, 96 blood samples were collected as control from healthy individuals (57 males and 39 females, average\u0026nbsp;\u003cem\u003eage \u003c/em\u003e34.3 \u0026plusmn;7.0) who referred to Novin genetics laboratory of Sari for other reasons except gastric diseases (Table 1). The normal control individuals were not age-matched with patients, but they were selected randomly to find the allele/genotype frequency of the polymorphisms in the local population. Blood samples were collected in EDTA containing tubes and preserved at -20 \u0026deg;C. This research was approved by the ethics committee in the Mazandaran University of Medical Sciences.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eDNA extraction\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eDNA was extracted from paraffin-embedded tissues using \u0026ldquo;YTA Genomic DNA Extraction mini kit (Yekta Tajhiz Azma, Iran) and standard salting out methods from blood samples, respectively. The extracted DNA was maintained at -20 \u0026deg; C until further study.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eGenotyping using PCR-RFLP method\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003ePCR (\u003cem\u003ePolymerase chain reaction\u003c/em\u003e) was applied to amplify exon 2 of \u003cem\u003eMUC1 \u003c/em\u003eand 5'-UTR region of \u003cem\u003ePSCA\u003c/em\u003e genes, including desired polymorphisms using specific primers (Table 3). Each reaction consists of 2\u0026mu;l template DNA, 11\u0026mu;l ready 2x PCR master mix RED (Ampliqon, Denmark), 11\u0026mu;l distilled water, 0.5\u0026mu;l of each primer at 25\u0026mu;M, in a total volume of 25\u0026mu;l. The PCR reactions were carried out under the following conditions: 94\u0026ordm;C for 5 minutes, followed by 35 cycles 94\u0026ordm;C for 60 seconds; 72\u0026ordm;C for 60 seconds. The annealing temperature of 60 \u0026ordm;C for 60 seconds was used for \u003cem\u003eMUC1 \u003c/em\u003egene and 56 \u0026ordm;C for 60 seconds used for \u003cem\u003ePSCA\u003c/em\u003e gene. PCR products were visualized on 1% agarose gel containing SYBR Safe staining. Then, PCR products were subjected to restriction digestion using 6\u0026mu;l of the PCR products and five units of restriction enzyme. Briefly, 188 bp PCR fragment of the \u003cem\u003eMUC1\u003c/em\u003e gene was digested using \u003cem\u003eAIWNI \u003c/em\u003eenzyme; a homozygous GG allele remained uncut, homozygous AA genotype was digested into 114 and 74 bp fragments, and heterozygous GA produced three fragments, 118, 114 and 74 bp, respectively (Figure 1, A). Also, 139 bp PCR fragment of\u0026nbsp; the \u003cem\u003ePSCA\u003c/em\u003e gene was digested using a \u003cem\u003eNIaIII \u003c/em\u003erestriction enzyme, genotype TT was digested to 2 fragments, 101 and 38 bp, genotype CC remained uncut and heterozygous CT showed three fragments, 139, 101 and 38 bp, respectively (Figure 1, B).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eStatistical analysis\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eChi-square test was used to evaluate differences in the distributions of demographic characteristics. The expected frequency of control genotypes was tested against the Hardy\u0026ndash;Weinberg equilibrium. The odds ratio (OR) and 95% confidence interval (CI) were calculated using a logistic regression model. A \u003cem\u003ep\u003c/em\u003e-value \u0026lt; 0.05 was considered statistically significant. Otherwise, the pooled ORs and 95% CIs without adjustments were calculated for the \u003cem\u003eMUC1\u003c/em\u003e polymorphism rs4074037 as allele (G \u003cem\u003evs\u003c/em\u003e. A), homozygous genotype (GG \u003cem\u003evs\u003c/em\u003e. AA), heterozygous (AG \u003cem\u003evs\u003c/em\u003e. AA), dominant (AG+AA \u003cem\u003evs. \u003c/em\u003eGG), recessive (AA \u003cem\u003evs. \u003c/em\u003eAG+GG) and over-dominant model (AA+GG \u003cem\u003evs.\u003c/em\u003e AG). For \u003cem\u003ePSCA\u003c/em\u003e polymorphism rs2294008, it was considered as allele (T \u003cem\u003evs\u003c/em\u003e. C), homozygous (TT \u003cem\u003evs\u003c/em\u003e. CC), heterozygous (CT \u003cem\u003evs\u003c/em\u003e. CC), dominant (CT+CC \u003cem\u003evs. \u003c/em\u003eTT), recessive (CC \u003cem\u003evs. \u003c/em\u003eCT+TT). The statistical analysis was performed using the IBM SPSS Statistics v21 software package (SPSS, Chicago, IL, USA).\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003eDemographic and clinical information of 99 patients with gastric cancer and 96 controls are shown in tables 1 and 2, respectively. Ninety nine patient samples were genotyped for \u003cem\u003ePSCA\u003c/em\u003e gene (rs2294008) and 91 patient samples for \u003cem\u003eMUC1\u003c/em\u003e gene (rs4072037) polymorphism. Genotype and allele frequencies of rs4072037 and rs2294008 and their associations with the risk of gastric cancer are presented in tables 4 and 5, respectively.\u003c/p\u003e\n\u003cp\u003eThe G allele frequency of rs4072037 is 64% in patients with gastric cancer compared with 78% in controls, respectively (Table 4). \u003cem\u003eMUC1\u003c/em\u003e rs4072037 polymorphism is associated with significant decreased gastric cancer risk in four genetic models: G \u003cem\u003evs.\u003c/em\u003e A (OR = 0.507, 95% CI: 0.322\u0026ndash;0.799, \u003cem\u003ep \u003c/em\u003e= 0.003); heterozygous AG compared with AA (OR = 4.296, 95% CI: 1.190\u0026ndash;15.517, \u003cem\u003ep \u003c/em\u003e= 0.026); dominant model AG+AA \u003cem\u003evs.\u003c/em\u003e GG (OR = 3.726, 95% CI: 2.033\u0026ndash;6.830, \u0026nbsp;\u003cem\u003ep \u003c/em\u003e= 0.0001); and over-dominant model AA+GG \u003cem\u003evs\u003c/em\u003e. G (OR = 0.223, 95% \u0026nbsp;CI: 0.120-0.413, \u0026nbsp;\u003cem\u003ep \u003c/em\u003e= 0.0001) (Table 4).\u003c/p\u003e\n\u003cp\u003eIn the current study, no significant association was observed between the\u0026nbsp;\u003cem\u003ePSCA \u003c/em\u003e5057C\u0026gt;T polymorphism and risk of gastric cancer in all genetic models (T \u003cem\u003evs.\u003c/em\u003e C (OR = 1.050, 95% CI: 0.652 \u0026ndash;1.693, \u003cem\u003ep \u003c/em\u003e= 0.840); homozygous TT \u003cem\u003evs.\u003c/em\u003e CC (OR = 0.903, 95% CI: 0.327 \u0026ndash;2.492, \u003cem\u003ep \u003c/em\u003e= 0.533); heterozygous CT \u003cem\u003evs.\u003c/em\u003e CC (OR = 1.228, 95% CI: 0.644 \u0026ndash;2.339, \u003cem\u003ep \u003c/em\u003e= 0.533); dominant model CT+CC \u003cem\u003evs.\u003c/em\u003e TT (OR = 1.137, 95% CI: 0.420 \u0026ndash;3.080, \u003cem\u003ep \u003c/em\u003e= 0.800); and recessive model CC \u003cem\u003evs.\u003c/em\u003e CT+TT (OR = 0.904, 95% CI: 0.505 \u0026ndash;1.620, \u003cem\u003ep \u003c/em\u003e= 0.735)). As a result, There was no statistically significant differences between the genotype and allele frequency of \u003cem\u003ePSCA\u003c/em\u003e (5057C\u0026gt;T) in cases and controls in this study (Table 5).\u003c/p\u003e\n\u003cp\u003eFurthermore, the result of interaction effects between \u003cem\u003eMUC1\u003c/em\u003e (rs4072037) and \u003cem\u003ePSCA\u003c/em\u003e (rs2294008) genotypes with gender is summarized in table\u0026nbsp;6.\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eDifferent studies revealed a decreased incidences of gastric cancer globally, but it is still the most common cancer in the north and northwestern parts of Iran (2). Mazandaran, Golestan, and Ardabil Provinces are high-risk for gastric cancer (2, 32). Gastric cancer is a multi-factorial disease; a high dietary intake of salt, the high prevalence of Helicobacter pylori (\u003cem\u003eH. pylori\u003c/em\u003e) infection, smoking and gastroesophageal reflux disease are the environmental factors in the pathogenesis of this disease in Iran (2, 9). Among genetic risk factors, \u003cem\u003eMUC1\u003c/em\u003e (5640G\u0026gt;A) and \u003cem\u003ePSCA\u003c/em\u003e (5057C\u0026gt;T) polymorphisms were reported in several studies earlier (33-36).\u003c/p\u003e\n\u003cp\u003eMUC1 is a large, transmembrane mucin glycoprotein expressed at the apical surface of most simple epithelia including stomach. Functions related to MUC1 are generally associated with mucins such as lubrication, hydration of cell surfaces, protection from microorganisms and degradative enzymes (37). MUC1 protein contains three different domains: short cytoplasmic, transmembrane and a large extracellular domain. The \u003cem\u003eMUC1\u003c/em\u003e gene in human is comprised of 7 exons that can be alternatively spliced to form different transcripts (37). At least twelve splice variants of \u003cem\u003eMUC1\u003c/em\u003e have been described (38). The SNP rs4072037G\u0026gt;A (5640G\u0026gt;A) located in the 5' side of the second exon determines the splicing acceptor site and produce two major \u003cem\u003eMUC1 \u003c/em\u003etranscripts. The \u0026ldquo;G\u0026rdquo; allele determines the variant type 2 or MUC1/B and contains the first 27 bp of the 2nd exon and have 9 amino acids longer than \u0026ldquo;A\u0026rdquo; allele, which create variant type 3 or MUC1/A in the N-terminal domain (39-41).\u003c/p\u003e\n\u003cp\u003eThis additional sequence is potentially changing its intracellular trafficking or subsequent processing. The impact of the nine additional amino acids of MUC1/A on the signaling functions and intracellular localization was investigated by Imbert-Fernandez and colleagues (41). They showed that COS-7 cell line transfected by plasmid containing MUC1/A or MUC1/B had similar protein expression and plasma membrane localization. This study also showed MUC1/B and MUC1/A differs in their ability to modulate tumor necrosis \u0026alpha; (TNF\u0026alpha;)-induced transcription of IL-1\u0026beta; and IL-8, inducing the basal TGF\u0026beta; expression; finally they show different inflammatory activities (41).\u003c/p\u003e\n\u003cp\u003eMUC1 could protect the gastric epithelial cells as physical barriers, so could inhibit \u003cem\u003eH. pylori \u003c/em\u003ebinding to gastric epithelial cells. The carriers of the short-short (SS) homozygous variant genotype, were at a high risk of\u0026nbsp; \u003cem\u003eH. pylori\u003c/em\u003e infection, compared to the carriers of the long-long (LL) and long-short (LS) genotypes of \u003cem\u003eMUC1\u003c/em\u003e variable number of tandem repeats (\u003cem\u003eVNTR\u003c/em\u003e) (42). Miao Li and colleagues, examined the relation between \u003cem\u003eH. pylori\u003c/em\u003e infection and three polymorphisms (rs4072037 at 1q22, rs13361707 at 5p13, and rs2274223 at 10q23) involved in the inflammatory response to the increase of gastric cancer risk. They reported that people infected by \u003cem\u003eH. pylori, \u003c/em\u003ecarrying the genotypes AA rs4072037, CT/CC rs13361707 and AG/GG rs2274223 showed an increased risk of gastric cancer(43).\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eDifferent studies (\u003c/em\u003eHanze Zhang et al., 2011, \u003ca href=\"https://scholar.google.com/citations?user=XPZKwOwAAAAJ\u0026amp;hl=en\u0026amp;oi=sra\"\u003eJ Kupcinskas\u003c/a\u003e et al., 2014) have \u003cem\u003eshown\u003c/em\u003e that the G allele locus on rs4072037 was\u0026nbsp;\u003cem\u003esignificantly associated\u003c/em\u003e\u0026nbsp;with a\u0026nbsp;\u003cem\u003edecreased gastric cancer risk\u003c/em\u003e\u0026nbsp;(44, 45). Xinyang Liu \u003cem\u003eet al\u003c/em\u003e., 2014 suggested the G allele at rs4072037 of the \u003cem\u003eMUC1\u003c/em\u003e gene might have a protective rule in people from Asian countries against gastric cancer. Also, they reported that the association was more prevalent in Asian population than in Caucasians (46).\u003c/p\u003e\n\u003cp\u003eIn this study, allelic comparison (G \u003cem\u003evs.\u003c/em\u003e A), genotype comparison (GA \u003cem\u003evs.\u003c/em\u003e AA; GG \u003cem\u003evs.\u003c/em\u003e AA), were done and dominant model (AG+AA \u003cem\u003evs.\u003c/em\u003e GG), recessive model (AA \u003cem\u003evs. \u003c/em\u003eAG+GG), over-dominant model (AA+GG \u003cem\u003evs.\u003c/em\u003e AG) was tested (47). We found that in this study, the rs4072037 AG genotype was significantly associated with the reduced risk of gastric cancer or it plays a protecting role [odds ratios (OR) = 4.296; 95% confidence interval (CI) = 1.190-15.517, \u003cem\u003ep \u003c/em\u003e= 0.026 for AG \u003cem\u003evs.\u003c/em\u003e AA].\u003c/p\u003e\n\u003cp\u003eA study by Hye-Rim Song \u003cem\u003eet al.\u003c/em\u003e, 2014, with 3,245 GC cases and 700 controls suggests that the rs4072037 AG genotype was significantly associated with a reduced risk of gastric cancer [odds ratios (OR) = 0.78; 95 % confidence interval (CI) = 0.67\u0026ndash;0.91 for AG \u003cem\u003evs.\u003c/em\u003e AA]. Their data indicated a significant association between the rs4072037 G allele and reduction in risk of gastric cancer (48). Another meta-analysis by Xi Gu\u003cem\u003eet al\u003c/em\u003e., 2018, which included seventeen case\u0026ndash;control studies (12551 cases and 13436 controls), suggests that the \u003cem\u003eMUC1\u003c/em\u003e rs4072037 polymorphism might decrease the risk of gastric cancer in four different genetic combination (G \u003cem\u003evs. \u003c/em\u003eA; AG \u003cem\u003evs. \u003c/em\u003eAA; GG \u003cem\u003evs. \u003c/em\u003eAA; AG+GG \u003cem\u003evs. \u003c/em\u003eAA). They also performed analysis using ethnicity along with G allele and found the cancer risk was decreased among Asian population but not Caucasian (49).\u003c/p\u003e\n\u003cp\u003eSimilar results (including 4,220 cases and 6,384 controls) have been obtained by Duan \u003cem\u003eet al\u003c/em\u003e, 2014 through evaluating the association between \u003cem\u003eMUC1\u003c/em\u003e (rs4072037) polymorphism and gastric cancer (50). Their study demonstrated that the \u003cem\u003eMUC1 \u003c/em\u003e(rs4072037) polymorphism is associated with risk of cancer in all genetic models (G \u003cem\u003evs.\u003c/em\u003e A; GA \u003cem\u003evs.\u003c/em\u003e AA; GG \u003cem\u003evs.\u003c/em\u003e AA; AG+AA \u003cem\u003evs.\u003c/em\u003e GG; GG \u003cem\u003evs.\u003c/em\u003e AG+AA). They suggested \u003cem\u003eMUC1 \u003c/em\u003e(rs4072037) polymorphism had a slightly reduced gastric cancer risk among Asian population. Also, this polymorphism was significantly associated with a decreased cancer risk in all genetic models except for homozygous recessive (AA) model in Caucasian population (50).\u003c/p\u003e\n\u003cp\u003eIn this study, \u003cem\u003eMUC1\u003c/em\u003e rs4072037 polymorphism was significantly associated with a decreased risk of cancer in all genetic models except for homozygous GG \u003cem\u003evs.\u003c/em\u003e AA and\u0026nbsp; recessive model AG+GG \u003cem\u003evs.\u003c/em\u003e AA (G \u003cem\u003evs.\u003c/em\u003e A: OR = 0.507, 95% CI: 0.322\u0026ndash;0.799, \u003cem\u003ep \u003c/em\u003e= 0.003; AG \u003cem\u003evs.\u003c/em\u003e AA: OR = 4.296, 95% CI: 1.190\u0026ndash;15.517, \u003cem\u003ep \u003c/em\u003e= 0.026; AG+AA \u003cem\u003evs.\u003c/em\u003e GG: OR = 3.726, 95%CI: 2.033\u0026ndash;6.830, \u003cem\u003ep \u003c/em\u003e= 0.0001; AA+GG \u003cem\u003evs.\u003c/em\u003e AG: (OR = 0.223, 95% CI: 0.120-0.413, \u003cem\u003ep \u003c/em\u003e= 0.0001)). Data from this case-control study indicated that four genetic models G \u003cem\u003evs.\u003c/em\u003e A, heterozygous GA (GA \u003cem\u003evs.\u003c/em\u003e AA), dominant (AG+AA \u003cem\u003evs.\u003c/em\u003e GG), over-dominant model (AA+GG \u003cem\u003evs.\u003c/em\u003e AG), were significantly associated with the decreased risk of cancer. Therefore, \u003cem\u003eMUC1\u003c/em\u003e rs4072037 polymorphism was associated with decreased risk of gastric cancer in northern Iran.\u003c/p\u003e\n\u003cp\u003eThe Prostate Stem Cell Antigen (\u003cem\u003ePSCA\u003c/em\u003e) is expressed in the gastric epithelium of the isthmus area. This area includes immature epithelial cells. PSCA expression increases in prostate cancer but it is reduced in gastric cancer and gastric intestinal metaplasia (51, 52). T allele carriers show lower transcriptional activity compared with the C allele carriers (5057C\u0026gt;T) in their gastric mucosa (31, 51). T allele carriers have nine amino acids more than C allele carriers (natural protein of 114 amino acid residues) (53). The association of \u003cem\u003ePSCA\u003c/em\u003e (5057C\u0026gt;T) variant was described in Korea and Japan population for the first time and the T allele was reported as a risk factor for gastric cancer (31). A study in Japan and Korea showed that 5057T allele plays a more significant role in diffuse gastric cancer compared with the intestinal gastric cancer (31, 54). Such results were also similar in the population of Poland and the United States (34). Other studies in Caucasian and Chinese population also confirmed that this polymorphism is a risk factor for diffuse and intestinal gastric cancer (55).\u003c/p\u003e\n\u003cp\u003eIn this study, \u003cem\u003ePSCA\u003c/em\u003e rs2294008 polymorphism was not significantly associated with an increased risk of cancer in all genetic models (T \u003cem\u003evs.\u003c/em\u003e C (OR = 1.050, 95% CI: 0.652 \u0026ndash;1.693, \u003cem\u003ep \u003c/em\u003e= 0.840); homozygous TT \u003cem\u003evs.\u003c/em\u003e CC (OR = 0.903, 95% CI: 0.327 \u0026ndash;2.492, \u003cem\u003ep \u003c/em\u003e= 0.533); heterozygous CT \u003cem\u003evs.\u003c/em\u003e CC (OR = 1.228, 95% CI: 0.644 \u0026ndash;2.339, \u003cem\u003ep \u003c/em\u003e= 0.533); dominant model CT+CC \u003cem\u003evs.\u003c/em\u003e TT (OR = 1.137, 95% CI: 0.420 \u0026ndash;3.080, \u003cem\u003ep \u003c/em\u003e= 0.800); and recessive model CC \u003cem\u003evs.\u003c/em\u003e CT+TT (OR = 0.904, 95% CI: 0.505 \u0026ndash;1.620, \u003cem\u003ep \u003c/em\u003e= 0.735) (Table 5). Therefore, \u003cem\u003ePSCA\u003c/em\u003e rs2294008 polymorphism was not associated with increased risk of gastric cancer in Northern Iran.\u003c/p\u003e"},{"header":"Conclusion","content":"\u003cp\u003eIn conclusion, this study evaluated the effect of \u003cem\u003eMUC1\u003c/em\u003e (rs4072037) and \u003cem\u003ePSCA\u003c/em\u003e (rs2294008) polymorphisms on GC risk in the Northern Iran population. Data from this study revealed that the \u003cem\u003eMUC1\u003c/em\u003e rs4072037 polymorphism was significantly associated with decreased risk of gastric cancer. However, the results could be important, especially for the interpretation of a genetic variant, which cause susceptibility to gastric cancer, and could be used as diagnostic markers in gastric cancer. In addition, \u003cem\u003ePSCA\u003c/em\u003e polymorphism did not show any relation to gastric cancer in our findings probably because of the type of gastric cancer or the small sample size.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eEthics approval and consent to participate\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis study was approved by the Ethical Committee of Mazandaran University of Medical Sciences and complied with the guidelines and principles of the Declaration. All participants signed written informed consent.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent for publication \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAll participants signed written informed consent for publication.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and material\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe datasets used and/or analyzed during the current study are available from the author for correspondence upon reasonable request.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interests\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors declare that they have no competing interests.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis work was supported by Mazandaran University of Medical Sciences.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthors' contributions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eMohammad bagherHashemi-soteh conceived and designed the study.\u003c/p\u003e\n\u003cp\u003eReza Alikhani performed the experiments.\u003c/p\u003e\n\u003cp\u003eAli Taravati analyzed the data.\u003c/p\u003e\n\u003cp\u003eMohammad bagherHashemi-soteh and Reza Aikhani wrote and edited the manuscript.\u003c/p\u003e\n\u003cp\u003eAll authors read and approved the final manuscript.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAcknowledgements\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWe would like to thank Mazandaran University of Medical Sciences for its financial support, and all the volunteers who participated in this study.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cp\u003eGWAS: Genome-Wide Association Studies\u003c/p\u003e\n\u003cp\u003eMUC1: Mucin 1\u003c/p\u003e\n\u003cp\u003ePSCA: Prostate Stem Cell Antigen\u003c/p\u003e\n\u003cp\u003eFFPE: Formalin fixed paraffin-embedded\u003c/p\u003e\n\u003cp\u003eTA-MUC1: tumor-associated MUC1\u003c/p\u003e\n\u003cp\u003eGPI: Glycosylphosphatidyl inositol\u003c/p\u003e\n\u003cp\u003eSNP: Single nucleotide polymorphism\u003c/p\u003e\n\u003cp\u003ePCR: \u003cem\u003ePolymerase chain reaction\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eRFLP: Restriction fragment length polymorphism\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eH. pylori\u003c/em\u003e: Helicobacter pylori\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eJemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. 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Int J Cancer. 2010;127(9):2183-9.\u003c/li\u003e\n\u003c/ol\u003e"},{"header":"Tables","content":"\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:.5in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-indent:-.5in;'\u003e\u003cspan style=\"font-size: 10px; font-family: Verdana, Geneva, sans-serif; color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:justify;text-indent:.2in;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTable 1: Demographic characteristics of the cases and controls.\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 130.2pt;border-top: 1pt solid black;border-left: none;border-bottom: 1pt solid black;border-right: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eVariables\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 135.05pt;border-top: 1pt solid black;border-left: none;border-bottom: 1pt solid black;border-right: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eCases (n = 99)\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 157.5pt;border-top: 1pt solid black;border-left: none;border-bottom: 1pt solid black;border-right: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eControls (n = 96)\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.85pt;border-top: 1pt solid black;border-left: none;border-bottom: 1pt solid black;border-right: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cem\u003eP\u003c/em\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 130.2pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eAge (years) (mean \u0026plusmn; SD)\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:72.05pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e67.5\u0026nbsp;\u0026plusmn;\u0026nbsp;10.9\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.0pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:81.0pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 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\u003ctd style=\"width: 76.5pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e%\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.85pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 130.2pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eMale\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e64\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e52.9\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 81pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e57\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e47.1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:44.85pt;border:none;border-bottom:solid black 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.448\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 130.2pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eFemale\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.05pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e35\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e47.3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 81pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e39\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.5pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e52.7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:.5in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-indent:-.5in;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:.5in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-indent:-.5in;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-indent:.2in;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTable 2.\u003cspan style=\"background: white;\"\u003e\u0026nbsp;\u003c/span\u003eTumor characteristics, including\u0026nbsp;tumor site, tumor grade, lymphatic invasion, perineural invasion, tumor stage and tumor type.\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cdiv align=\"center\" style='margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:107%;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\n \u003ctable style=\"width: 3.3e+2pt;border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width: 233.15pt;border-top: 1pt solid black;border-left: none;border-bottom: 1pt solid black;border-right: none;padding: 0in 5.4pt;height: 8.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan dir=\"RTL\" style=\"background: white;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cstrong\u003eCharacteristic\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.7pt;border-top: 1pt solid black;border-left: none;border-bottom: 1pt solid black;border-right: none;padding: 0in 5.4pt;height: 8.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eFrequency (%)\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"6\" style=\"width:133.95pt;border:none;border-bottom:solid black 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:10.75pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eTumor site\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.2pt;border: none;padding: 0in 5.4pt;height: 10.75pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eCardia\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.7pt;border: none;padding: 0in 5.4pt;height: 10.75pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e18 (33.3)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.2pt;border: none;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eFundus\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.7pt;border: none;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0 (0.0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.2pt;border: none;padding: 0in 5.4pt;height: 3.25pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eBody\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.7pt;border: none;padding: 0in 5.4pt;height: 3.25pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e11 (20.4)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.2pt;border: none;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAntrum\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.7pt;border: none;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e18 (33.3)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.2pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eoverlapping\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.7pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e7 (13.0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.2pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTotal\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.7pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e54(100)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"4\" style=\"width:133.95pt;border:none;border-bottom:solid black 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:8.95pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eGrade\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.2pt;border: none;padding: 0in 5.4pt;height: 8.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eI\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.7pt;border: none;padding: 0in 5.4pt;height: 8.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e13 (18.8)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.2pt;border: none;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eII\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.7pt;border: none;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e39 (56.5)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.2pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0in 5.4pt;height: 7.6pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eIII\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.7pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0in 5.4pt;height: 7.6pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e17 (24.6)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.2pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0in 5.4pt;height: 7.6pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTotal\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.7pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0in 5.4pt;height: 7.6pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e69(100)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" style=\"width:133.95pt;border:none;border-bottom:solid black 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:6.7pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eLymphatic invasion\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.2pt;border: none;padding: 0in 5.4pt;height: 6.7pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003ePresent\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.7pt;border: none;padding: 0in 5.4pt;height: 6.7pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e27 (67.5)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.2pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAbsent\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.7pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e13 (32.5)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.2pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTotal\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.7pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e40(100)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" style=\"width:133.95pt;border:none;border-bottom:solid black 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:9.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003ePerineural invasion\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.2pt;border: none;padding: 0in 5.4pt;height: 9.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003ePresent\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.7pt;border: none;padding: 0in 5.4pt;height: 9.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e28 (54.9)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.2pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAbsent\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.7pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e23 (45.1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.2pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTotal\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.7pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e51(100)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"5\" style=\"width:133.95pt;border:none;border-bottom:solid black 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:9.85pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eT\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.2pt;border: none;padding: 0in 5.4pt;height: 9.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.7pt;border: none;padding: 0in 5.4pt;height: 9.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e3 (6.1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.2pt;border: none;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.7pt;border: none;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e19 (38.8)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n 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0);\"\u003e26 (53.1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.2pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.7pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1 (2.0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.2pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTotal\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.7pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e49(100)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"5\" style=\"width:133.95pt;border:none;border-bottom:solid black 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:7.6pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eN\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.2pt;border: none;padding: 0in 5.4pt;height: 7.6pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.7pt;border: none;padding: 0in 5.4pt;height: 7.6pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e19 (36.6)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.2pt;border: none;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.7pt;border: none;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e18 (37.5)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.2pt;border: none;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.7pt;border: none;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e9 (118.8)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.2pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.7pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2 (4.2)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.2pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTotal\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.7pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e48(100)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" style=\"width:133.95pt;border:none;border-bottom:solid black 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eM\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.2pt;border: none;padding: 0in 5.4pt;height: 8.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.7pt;border: none;padding: 0in 5.4pt;height: 8.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e6 (66.7)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.2pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.7pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e3 (33.3)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.2pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTotal\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.7pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e9(100)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"5\" style=\"width:133.95pt;border:none;border-bottom:solid black 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:6.25pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eStage\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.2pt;border: none;padding: 0in 5.4pt;height: 6.25pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eI\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.7pt;border: none;padding: 0in 5.4pt;height: 6.25pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e8 (19.0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.2pt;border: none;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eII\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.7pt;border: none;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e16 (38.1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.2pt;border: none;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eIII\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.7pt;border: none;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e15 (35.7)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.2pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eIV\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.7pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e3 (7.1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.2pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTotal\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.7pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e42(100)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" style=\"width:133.95pt;border:none;border-bottom:solid black 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:3.25pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eTumor type\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.2pt;border: none;padding: 0in 5.4pt;height: 3.25pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eDiffuse\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.7pt;border: none;padding: 0in 5.4pt;height: 3.25pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e14 (73.7)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.2pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eIntestinal\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.7pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e5 (26.3)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.2pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTotal\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.7pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0in 5.4pt;height: 0.1in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:3.0pt;margin-bottom:.0001pt;margin-left:3.0pt;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e19(100)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n\u003c/div\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:.5in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-indent:-.5in;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:.5in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-indent:-.5in;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:.5in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-indent:-.5in;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:.5in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-indent:-.5in;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:.5in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-indent:-.5in;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:.5in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-indent:-.5in;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:.5in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-indent:-.5in;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:.5in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-indent:-.5in;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:.5in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-indent:-.5in;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:.5in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-indent:-.5in;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTable 3. Primer sequences, PCR size and PCR-RFLP fragments using \u003cem\u003eAIWNI\u003c/em\u003e and \u003cem\u003eNIaIII\u003c/em\u003e restriction enzymes for\u0026nbsp;\u003cem\u003eMUC1\u0026nbsp;\u003c/em\u003e5640G\u0026gt;A (rs4072037) and\u0026nbsp;\u003cem\u003ePSCA\u003c/em\u003e\u0026nbsp;5057C\u0026gt;T (rs2294008) polymorphisms, respectively.\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:71.75pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eSNP\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:153.4pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003ePrimer sequence\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003ePCR Size\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e(bp)\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eRestriction enzyme\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:143.15pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eDigestion products (bp)\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 71.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 153.4pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:48.9pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eWild-type\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:.5in;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eMutant\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:58.25pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eHeterozygous\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:71.75pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003eMUC1\u0026nbsp;\u003c/em\u003e5640G\u0026gt;A (rs4072037)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:153.4pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eF: TAAAGACCCAACCCTATGACT\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:49.6pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e188\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:49.6pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003eAIWNI\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:48.9pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e188\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:.5in;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e114,74\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:58.25pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e188,114,74\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:153.4pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eR: AGAGTACGCTGCTGGTCATACTC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:71.75pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003ePSCA\u003c/em\u003e\u0026nbsp;5057C\u0026gt;T (rs2294008\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:153.4pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eF: GAAACCCGCTGGTGTTGACT\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:49.6pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e139\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:49.6pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003eNIaIII\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:48.9pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e139\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:.5in;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e101,38\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:58.25pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e139,101,38\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:153.4pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eR: GCCAAGCCTGCCATCAACAG\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:107%;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 107%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTable 4. Comparison of genotype and allele frequencies of \u003cem\u003eMUC1\u003c/em\u003e gene polymorphisms between gastric cancer patients (n=91) \u0026nbsp; and normal controls (n=96) using chi-square analysis.\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width: 4.7e+2pt;margin-left:-.05in;border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:88.4pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eSNP\u003csup\u003ea\u003c/sup\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:85.05pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eGenotype/Allele\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:78.0pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eControls(n=96)\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:71.1pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eCases(n=91)\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:99.25pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eOR\u003csup\u003eb\u003c/sup\u003e (95% CI\u003csup\u003ec\u003c/sup\u003e)\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.35pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cem\u003eP\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e-value\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"8\" style=\"width:88.4pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cem\u003eMUC1\u003csup\u003ed\u0026nbsp;\u003c/sup\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e5640G\u0026gt;A (rs4072037)\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:85.05pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:78.0pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e8 (8.4%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:71.1pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e4 (4.1%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:99.25pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.35pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:85.05pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAG\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n 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style=\"width:99.25pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e4.296 (1.190-15.517)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.35pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.026\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n 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style=\"width:71.1pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e29 (32%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:99.25pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.951 (0.265-3.417)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.35pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.938\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:85.05pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAG+GG\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:78.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e88 (91.6%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:71.1pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e87 (95.9%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:99.25pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.506 (0.147-1.741)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.35pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.280\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n 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style=\"width:49.35pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.0001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:85.05pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAA+GG\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:78.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e69 (71.9%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:71.1pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e33 (36.1%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:99.25pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.223 (0.120-0.413)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.35pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.0001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n 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style=\"width:71.1pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e66 (36%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:99.25pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.35pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:85.05pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eG\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:78.0pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e149 (78%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:71.1pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e116 (64%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:99.25pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.507 (0.322 - 0.799)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.35pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.003\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:107%;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%;\"\u003ea.\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"line-height: 107%;\"\u003e\u0026nbsp;\u003cem\u003e\u003cspan style=\"background:white;\"\u003eSingle nucleotide polymorphisms, b.\u0026nbsp;\u003c/span\u003e\u003c/em\u003eodds ratio, c. confidence interval,\u0026nbsp;d.\u003c/span\u003e\u003cspan style=\"line-height: 107%; background: white;\"\u003e\u0026nbsp;Mucin 1\u003cem\u003e\u0026nbsp;\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTable 5. Comparison of genotype and allele frequencies of \u003cem\u003ePSCA*\u003c/em\u003e gene polymorphisms between gastric cancer patients (n= 99) and normal controls (n= 96) using chi-square analysis.\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width: 4.7e+2pt;border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:84.8pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eSNP\u003csup\u003ea\u003c/sup\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:85.05pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eGenotype/Allele\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:78.0pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eControls(n=96)\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eCases(n=99)\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:99.25pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eOR\u003csup\u003eb\u003c/sup\u003e (95% CI\u003csup\u003ec\u003c/sup\u003e)\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cem\u003eP\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e-value\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"7\" style=\"width:84.8pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cem\u003ePSCA\u003csup\u003ed\u003c/sup\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u0026nbsp;5057C\u0026gt;T (rs2294008\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:85.05pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eCC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e63 (65.6%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e62 (62.6%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:99.25pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:85.05pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eCT\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e24 (25%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e29 (29.3%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.228 (0.644 - 2.339)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.533\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:85.05pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTT\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e9 (9.4%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e8 (8.1%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.903 (0.372 -2.492)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.844\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:85.05pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eCT+TT\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e34 (34.4%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e37 (37.4%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.904(0.505-1.620)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.735\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:85.05pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eCT+CC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e90 (90.6%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.85pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e91 (91.9%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 99.25pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.137(0.420-3.080)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align: justify;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.800\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:85.05pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:78.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e150 (78%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e153 (77%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:99.25pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:85.05pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eT\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:78.0pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e42 (22%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e45 (23%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:99.25pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.050 (0.652 - 1.693)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.840\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:2.25pt;line-height:107%;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; background: white;\"\u003ea. Single nucleotide polymorphisms, b.\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"line-height: 107%;\"\u003eodds ratio, c. confidence interval,*\u003c/span\u003e\u003cspan style=\"font-weight: bold;\"\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; background: white; font-weight: normal;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; background: white;\"\u003eProstate stem cell antigen\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:107%;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; background: white; font-style: normal;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:107%;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTable 6. D\u003cspan style=\"background:white;\"\u003eistribution\u0026nbsp;of genotypes \u003cem\u003eMUC1\u0026nbsp;\u003c/em\u003e(\u003c/span\u003ers4072037)\u003cspan style=\"background: white;\"\u003e\u0026nbsp;and \u003cem\u003ePSCA\u0026nbsp;\u003c/em\u003e(rs2294008) polymorphisms\u0026nbsp;according to\u0026nbsp;\u003c/span\u003eSex\u003cspan style=\"background: white;\"\u003e.\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width:496.15pt;border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:.6in;border-top:solid #7F7F7F 1.0pt;border-left: none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eSex\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:44.45pt;border-top:solid #7F7F7F 1.0pt;border-left: none;border-bottom:solid #7F7F7F 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eGroup\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 161.65pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cem\u003eMUC1\u0026nbsp;\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e5640G\u0026gt;A\u003c/strong\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003cstrong\u003e(\u003c/strong\u003e\u003cstrong\u003ers4072037)\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 41.9pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cem\u003ep\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e-value\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 167.15pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: 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none;border-image: initial;border-bottom: 1pt solid rgb(127, 127, 127);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eGA\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.55pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid rgb(127, 127, 127);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: 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style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eCase\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.55pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e18(30.5%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.55pt;border: none;padding: 0in 5.4pt;vertical-align: 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style=\"width:41.9pt;border:none;border-bottom:solid #7F7F7F 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.0001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.55pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 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style=\"color: rgb(0, 0, 0);\"\u003e6(9.4%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:37.8pt;border:none;border-bottom:solid #7F7F7F 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height:normal;font-size:15px;font-family:\"Calibri\",sans-serif;text-align:center;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.92\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 44.45pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eControl\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.55pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e35(61.4%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.55pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e17(28.9%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.55pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e5(8.8%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.55pt;border-top: 1pt solid rgb(127, 127, 127);border-left: none;border-bottom: 1pt solid rgb(127, 127, 127);border-right: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 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style='margin-top:0in;margin-right:0in;margin-bottom:.0001pt;margin-left:0in;line-height: normal;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e4(10.3%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:107%;font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0); font-size: 10px; font-family: Verdana, Geneva, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"bmc-medical-genetics","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"mgtc","sideBox":"Learn more about [BMC Medical Genetics](http://bmcmedgenet.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/mgtc/default.aspx","title":"BMC Medical Genetics","twitterHandle":"BMC_series","acdcEnabled":false,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"Gastric cancer, Genome-Wide Association Studies (GWAS), rs4072037G\u003eA polymorphism, rs2294008 C\u003eT","lastPublishedDoi":"10.21203/rs.2.24296/v3","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.2.24296/v3","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground: \u003c/strong\u003eGastric cancer is the fourth most common cancer worldwide and the second leading cause of cancer-related death. Genome-Wide Association Studies (GWAS) have shown that genetic diversities \u003cem\u003eMUC1 \u003c/em\u003e(Mucin 1) and \u003cem\u003ePSCA \u003c/em\u003e(Prostate Stem Cell Antigen) genes are involved in gastric cancer. The aim of this study was to determine the association between rs4072037G\u0026gt;A polymorphism in \u003cem\u003eMUC1\u003c/em\u003e and rs2294008 C\u0026gt;T in \u003cem\u003ePSCA\u003c/em\u003e gene with gastric cancer in northern Iran. \u003c/p\u003e\u003cp\u003e\u003cstrong\u003eMethods:\u003c/strong\u003e DNA was extracted from 99 formalin fixed paraffin-embedded (FFPE) tissue samples of gastric cancer and 96 blood samples from healthy individuals (sex matched) as controls. DNA was extracted followed by PCR using specific primers. Two desired polymorphisms, 5640G\u0026gt;A and 5057C\u0026gt;T for \u003cem\u003eMUC1 \u003c/em\u003eand \u003cem\u003ePSCA \u003c/em\u003egenes were genotyped using PCR-RFLP method.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eResults: \u003c/strong\u003eThe G allele at rs4072037 of \u003cem\u003eMUC1\u003c/em\u003e gene was associated with a significant decreased gastric cancer risk (OR = 0.507, 95% CI: 0.322–0.799, \u003cem\u003ep \u003c/em\u003e= 0.003). A significant decreased risk of gastric cancer was observed in people with either AG \u003cem\u003evs.\u003c/em\u003e AA, AG+AA \u003cem\u003evs.\u003c/em\u003e GG and AA+GG \u003cem\u003evs.\u003c/em\u003e AG genotypes of \u003cem\u003eMUC1\u003c/em\u003e polymorphism (OR = 4.296, 95% CI: 1.190–15.517, \u003cem\u003ep \u003c/em\u003e= 0.026), (OR = 3.726, 95% CI: 2.033–6.830, \u003cem\u003ep \u003c/em\u003e= 0.0001) and (OR = 0.223, 95% CI: 0.120-0.413, \u003cem\u003ep \u003c/em\u003e= 0.0001) respectively. Overall, no significant association was observed between the\u0026nbsp;\u003cem\u003ePSCA \u003c/em\u003e5057C\u0026gt;T polymorphism and risk of gastric cancer in all genetic models. \u003c/p\u003e\u003cp\u003e\u003cstrong\u003eConclusion: \u003c/strong\u003eResults indicated that the \u003cem\u003eMUC1\u003c/em\u003e 5640G\u0026gt;A polymorphism may have protective effect for gastric cancer and could be considered a potential molecular marker in gastric cancer in the Northern Iran population.\u003c/p\u003e\u003cp\u003e\u003cbr\u003e\u003c/p\u003e","manuscriptTitle":"Association of MUC1 5640G\u0026gt;A and PSCA 5057C\u0026gt;T polymorphisms with the Risk of Gastric Cancer in Northern Iran","msid":"","msnumber":"","nonDraftVersions":[{"code":3,"date":"2020-06-16 23:40:50","doi":"10.21203/rs.2.24296/v3","editorialEvents":[{"type":"communityComments","content":0},{"type":"editorAssigned","content":"","date":"2020-06-15T12:00:00+00:00","index":"","fulltext":""},{"type":"decision","content":"Minor revision","date":"2020-06-15T12:00:00+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2020-06-14T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2020-06-14T12:00:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-medical-genetics","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"mgtc","sideBox":"Learn more about [BMC Medical Genetics](http://bmcmedgenet.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/mgtc/default.aspx","title":"BMC Medical Genetics","twitterHandle":"BMC_series","acdcEnabled":false,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}},{"code":2,"date":"2020-05-13 15:47:07","doi":"10.21203/rs.2.24296/v2","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Minor revision","date":"2020-05-26T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-05-25T12:00:00+00:00","index":2,"fulltext":"Recommendation: Accept without revision\nForm responses:\n---\n\nComments to Author:\n---\nManuscript has been revised sufficiently for publication.* Are the methods appropriate and well described?: **Yes**\n* Does the work include the necessary controls?: **Yes**\n* Are the conclusions drawn adequately supported by the data shown?: **Yes**\n* Are you able to assess any statistics in the manuscript or would you recommend an additional statistical review?: **I am able to assess the statistics**\n* Quality of written English: **Acceptable**\n* Declaration of competing interests: **I declare that I have no competing interests**\n* Reviewer Publication Consent. I agree for my report to be made available under an Open Access Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manuscript is accepted for publication. Any comments that I do not wish to be included in the published report have been included as confidential comments to the editor, which will not be published.: **I agree to the terms of the CC-BY 4.0 license; please do not publish my name with my report. (default)**\n"},{"type":"reviewerAgreed","content":"","date":"2020-05-07T12:00:00+00:00","index":2,"fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-04-30T12:00:00+00:00","index":1,"fulltext":"Recommendation: Accept after discretionary revisions\nForm responses:\n---\n\nComments to Author:\n---\nI have no further comments.* Are the methods appropriate and well described?: **Yes**\n* Does the work include the necessary controls?: **No**\n* Are the conclusions drawn adequately supported by the data shown?: **Yes**\n* Are you able to assess any statistics in the manuscript or would you recommend an additional statistical review?: **I recommend additional statistical review**\n* Quality of written English: **Acceptable**\n* Declaration of competing interests: **I declare that I have no competing interests.**\n* Reviewer Publication Consent. I agree for my report to be made available under an Open Access Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manuscript is accepted for publication. Any comments that I do not wish to be included in the published report have been included as confidential comments to the editor, which will not be published.: **I agree to the terms of the CC-BY 4.0 license; please publish my name with my report.**\n"},{"type":"reviewersInvited","content":"","date":"2020-04-29T12:00:00+00:00","index":"","fulltext":""},{"type":"reviewerAgreed","content":"","date":"2020-04-29T12:00:00+00:00","index":1,"fulltext":""},{"type":"editorAssigned","content":"","date":"2020-04-27T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2020-04-26T12:00:00+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2020-02-20T12:00:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-medical-genetics","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"mgtc","sideBox":"Learn more about [BMC Medical Genetics](http://bmcmedgenet.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/mgtc/default.aspx","title":"BMC Medical Genetics","twitterHandle":"BMC_series","acdcEnabled":false,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}},{"code":1,"date":"2020-02-24 15:54:51","doi":"10.21203/rs.2.24296/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Major revision","date":"2020-04-06T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-03-21T12:00:00+00:00","index":2,"fulltext":"Recommendation: Reject\nForm responses:\n---\n\nComments to Author:\n---\nMajor Comments:\nOne of the major shortcoming of the manuscript is sample size to draw meaningful conclusion. The authors should include more cases and controls to substantiate their findings. Additionally, PCR-RFLP is not exactly a cutting edge method when sequencing is widely used considering the rapid improvement in technology and lower cost per sample. I am afraid at this moment the manuscript needs major overhaul for consideration for publication.\nMinor comments:\n1. Authors should explain how they have compared gastric cancer FFPE tissue samples for cases with healthy blood control samples.\n2. Figure 1A gel picture showed non specific bands.\n3. Page 4, first line has a typo PCSA rather than PSCA.\n4. Page 6, line 28 has a typo \"cytoplasmi\" rather than cytoplasmic.\n5. Page 8, line 39: \"especially for the interpretation \"of\" genetic variance… needs to be corrected.\n6. Line numbers in all the pages need to be corrected.\n7. PSCA in abstract is given as \"Prostate cell surface antigen\" which should be \"Prostate Stem Cell Antigen\".\n* Are the methods appropriate and well described?: **Yes**\n* Does the work include the necessary controls?: **Yes**\n* Are the conclusions drawn adequately supported by the data shown?: **No**\n* Are you able to assess any statistics in the manuscript or would you recommend an additional statistical review?: **I am able to assess the statistics**\n* Quality of written English: **Needs some language corrections before being published**\n* Declaration of competing interests: **I declare that I have no competing interests**\n* I agree to the open peer review policy of the journal. I understand that my name will be included on my report to the authors and, if the manuscript is accepted for publication, my named report including any attachments I upload will be posted on the website along with the authors' responses. I agree for my report to be made available under an Open Access Creative Commons CC-BY license (http://creativecommons.org/licenses/by/4.0/). I understand that any comments which I do not wish to be included in my named report can be included as confidential comments to the editors, which will not be published.: ** I agree to the open peer review policy of the journal**\n"},{"type":"editorInvitedReview","content":"","date":"2020-03-17T12:00:00+00:00","index":1,"fulltext":"Recommendation: Major revisions required\nForm responses:\n---\n\nComments to Author:\n---\nIn the present article the authors tried establish a risk of MUC1 and PSCA gene polymorphisms (rs4072037 and rs2294008 respectively) with gastric cancer in Iranian population. I have few observations and recommendations, those are as follows,\n\n1. Authors mentioned that the rs2294008 variant is located in start codon of exon 1 of PSCA gene, that needs to be corrected. This variant is actually located at the 5'UTR region of the gene in the major transcript NM_005672.5. The statement and the description given of this variant in page 3 (end lines) and 4 (starting lines) needs to be changed as per the correct location.\n\n2. While the cancer affected tissues from the patients have been used as case, blood samples collected from the normal individuals used as control, that creates a major bias. The authors should use normal tissue samples collected from similar age group as controls. If normal tissue samples are not available then they should use blood samples for the cases also as also used in the references mentioned in the article (Reference numbers 42, 43).\n\n3. The authors should also explore the role of environmental factors in the context of these variants by doing a gene-environment interaction kind of a study and include in the article, although the outcome of the study is mainly protective effect rather than deleterious effect.\n\n* Are the methods appropriate and well described?: **Yes**\n* Does the work include the necessary controls?: **No**\n* Are the conclusions drawn adequately supported by the data shown?: **No**\n* Are you able to assess any statistics in the manuscript or would you recommend an additional statistical review?: **I recommend additional statistical review**\n* Quality of written English: **Acceptable**\n* Declaration of competing interests: **No**\n* I agree to the open peer review policy of the journal. I understand that my name will be included on my report to the authors and, if the manuscript is accepted for publication, my named report including any attachments I upload will be posted on the website along with the authors' responses. I agree for my report to be made available under an Open Access Creative Commons CC-BY license (http://creativecommons.org/licenses/by/4.0/). I understand that any comments which I do not wish to be included in my named report can be included as confidential comments to the editors, which will not be published.: ** I agree to the open peer review policy of the journal**\n"},{"type":"reviewerAgreed","content":"","date":"2020-03-03T12:00:00+00:00","index":2,"fulltext":""},{"type":"reviewerAgreed","content":"","date":"2020-03-02T12:00:00+00:00","index":1,"fulltext":""},{"type":"editorAssigned","content":"","date":"2020-02-23T12:00:00+00:00","index":"","fulltext":""},{"type":"reviewersInvited","content":"","date":"2020-02-23T12:00:00+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2020-02-21T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2020-02-20T12:00:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-medical-genetics","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"mgtc","sideBox":"Learn more about [BMC Medical Genetics](http://bmcmedgenet.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/mgtc/default.aspx","title":"BMC Medical Genetics","twitterHandle":"BMC_series","acdcEnabled":false,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"5f4b1605-ea54-4f60-b221-d5956806e272","owner":[],"postedDate":"June 16th, 2020","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[{"id":121758,"name":"Medical Genetics"}],"tags":[],"updatedAt":"2020-07-19T15:01:56+00:00","versionOfRecord":{"articleIdentity":"rs-14855","link":"https://doi.org/10.1186/s12881-020-01085-z","journal":{"identity":"bmc-medical-genetics","isVorOnly":false,"title":"BMC Medical Genetics"},"publishedOn":"2020-07-13 12:00:00","publishedOnDateReadable":"July 13th, 2020"},"versionCreatedAt":"2020-06-16 23:40:50","video":"","vorDoi":"10.1186/s12881-020-01085-z","vorDoiUrl":"https://doi.org/10.1186/s12881-020-01085-z","workflowStages":[]},"version":"v3","identity":"rs-14855","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"identity":"rs-14855","version":["v3"]},"buildId":"WrCJVZZCHTDjtuVLN7oU0","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}