[The malignant potential of ovarian atypical endometriosis]

Guo L, L Guo, Linghong Guo, Liu T, T Liu, Lang J, Jinghe Lang, J Lang
Zhonghua bing li xue za zhi = Chinese journal of pathology · 2001 · vol. 30(3) , pp. 169–72 · PMID:11866970 · W162424732
Other OA: closed CC0 ⤵ 5 in-corpus citations
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This retrospective study found that ovarian atypical endometriosis exhibits a spectrum of changes transitioning to endometrioid adenocarcinoma and shares common genetic lesions with coexisting carcinomas, suggesting a precancerous potential.

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Abstract

OBJECTIVE: To investigate the malignant potential of ovarian atypical endometriosis and ovarian endometrioid adenocarcinoma. METHODS: 12 cases of ovarian endometroid adenocarcinoma with associated endometriosis were reviewed retrospectively. Microsatellite markers were used to detect the loss of heterozygosity on chromosome 10q23 in ovarian carcinoma and their coexisting endometriosis. RESULTS: Among the 12 cases, benign eosinophilic metaplasia was observed in 8 cases, 5 of which (41.7%) with atypia. In these 5 cases, a spectrum of benign-atypical endometriosis with a transition to endometrioid adenocarcinoma was identified, and common genetic lesions were also detected in 2 of the 5 atypical endometriosis and their coexisting carcinomas. CONCLUSION: Histological observations as well as the molecular genetic evidence indicate that ovarian atypical endometriosis may possess a precancerous potential or play a role in the pathogenesis of certain malignant ovarian cancers.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Ovarian Diseases Precancerous Conditions Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma Adult Adult Disease Progression Disease Progression Endometriosis Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Female

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