Perceived control as a resilience factor: Influences on neural, physiological and affective stress responses and mental health

Perceived control as a resilience factor: Influences on neural, physiological and affective stress responses and mental health | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Perceived control as a resilience factor: Influences on neural, physiological and affective stress responses and mental health Michèle Wessa, Bianca Kollmann, Jana Meier, Benjamin Meyer, Kenneth Yuen, and 2 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-5189916/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 15 Jan, 2026 Read the published version in Translational Psychiatry → Version 1 posted 12 You are reading this latest preprint version Abstract Perceived control is a key mechanism implicated in stress resilience. A tendency to perceive control over stressors may protect individuals against negative outcomes across various situations by increasing active coping and preventing exacerbated stress reactions. Assuming that individual differences in perceived control during an uncontrollable stress task may represent an underlying resilience factor, we investigated associations of perceived control with neural, endocrine, and affective responses to a different, psychosocial stressor, and with overall mental health. 116 male participants aged 18-30 completed a psychosocial stress task, and we assessed stress responses via functional magnetic resonance imaging, cortisol levels, and affective state questionnaires. General mental health was assessed via self-report. Perceived control was measured during a second, uncontrollable stress task and growth mixture modeling revealed a high- and a low-control class. Comparison of these classes showed that the high-control class experienced less helplessness during the uncontrollability task and demonstrated more flexible responses to psychosocial stress as reflected in cortisol secretion and activation of the bilateral posterior insula. Further, the high-control class reported fewer psychosomatic symptoms and a less external locus of control. These findings suggest that perceived control acts as a resilience factor, influencing stress processing across multiple domains. The study highlights the potential for perceived control to be harnessed in resilience-building interventions and underscores the need for further experimental and longitudinal research to confirm its role in modulating stress responses. Health sciences/Diseases/Psychiatric disorders/Depression Biological sciences/Neuroscience Biological sciences/Psychology Figures Figure 1 Figure 2 Figure 3 Figure 4 Full Text Additional Declarations The authors have declared there is NO conflict of interest to disclose Supplementary Files FigureS1Manipulationchecks.pdf Figure S1: Manipulation checks Shows changes in self-reported affect and cortisol over the course of the experimental manipulations on testing days 1+2 for all participants (aggregated across perceived control classes). PDF-file. FigureS2Classdifferencesinselfreportmeasures.pdf Figure S2: Differences between the perceived control classes in self-report measures Plots of all outcomes included into the self-report MANOVA by perceived control class. Errorbars denote bootstrapped 95% confidence intervals. n.s.: non-significant, * pHolm < .05, ** pHolm < .01, *** pHolm < .001. PDF-file. FigureS3NeuralresponsetoScanSTRESSCacrossclasses.pdf Figure S3: Neural response to the ScanSTRESS-C across classes Significant clusters for the effects of stress (a) and no stress (b) in the ScanSTRESS-C aggreagated across perceived control classes. Activation maps are thresholded at p=.05 FWE-corrected on peak-level and overlayed onto SPM152 template. PDF-file. TableS1CorrelationsofinternalandexternalLoCwithstressoutcomesandmentalhealth.doc Table S1: Correlations of internal and external LoC with stress outcomes and mental health. Shows the correlations of all the outcomes reported in the paper with locus of control (LoC). No correlations are significant, indicating that perceived control classes better predict stress outcomes and mental health than LoC. Word-file. TableS2SignificantclustersforthestresseffectintheScanSTRSSC.doc Table S2: Significant clusters for stress effect in the ScanSTRESS-C Shows significant clusters activated and deactivated under the Stress vs. noStress conditions of the ScanSTRESS-C, aggregated across classes in the whole sample. Word-file. TableS3ClustersdifferingsignificantlybetweentheclassesintheScanSTRSSC.doc Table S3: Clusters differing significantly between the classes in the ScanSTRESS-C Shows clusters that significantly differ between the classes in the contrast Stress vs. noStress and the inverse contrast. Three clusters emerged. The low-control class shows increased activation of the bilateral posterior insula and the primary motor cortex under psychosocial stress. Word-file. Cite Share Download PDF Status: Published Journal Publication published 15 Jan, 2026 Read the published version in Translational Psychiatry → Version 1 posted Unknown event 12 Aug, 2025 Editorial decision: Reject after peer review 19 Dec, 2024 Review # 3 received at journal 16 Dec, 2024 Review # 1 received at journal 28 Nov, 2024 Review # 2 received at journal 21 Nov, 2024 Reviewer # 3 agreed at journal 19 Nov, 2024 Reviewer # 2 agreed at journal 14 Nov, 2024 Reviewer # 1 agreed at journal 13 Nov, 2024 Reviewers invited by journal 12 Nov, 2024 Editor assigned by journal 02 Oct, 2024 Submission checks completed at journal 02 Oct, 2024 First submitted to journal 01 Oct, 2024 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-5189916","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":377383543,"identity":"48a879cf-b09b-4439-b656-473ed499b120","order_by":0,"name":"Michèle Wessa","email":"data:image/png;base64,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","orcid":"","institution":"Central Institute for Mental Health","correspondingAuthor":true,"prefix":"","firstName":"Michèle","middleName":"","lastName":"Wessa","suffix":""},{"id":377383544,"identity":"f93feb61-3c8b-4939-ac94-0fdce5001256","order_by":1,"name":"Bianca Kollmann","email":"","orcid":"","institution":"Central Institute for Mental Health","correspondingAuthor":false,"prefix":"","firstName":"Bianca","middleName":"","lastName":"Kollmann","suffix":""},{"id":377383545,"identity":"7321d875-726f-4317-b36b-50cd9cd21cdc","order_by":2,"name":"Jana Meier","email":"","orcid":"https://orcid.org/0000-0003-1298-7853","institution":"","correspondingAuthor":false,"prefix":"","firstName":"Jana","middleName":"","lastName":"Meier","suffix":""},{"id":377383546,"identity":"9fdffb3e-0e90-4d4a-9cb3-430d856df696","order_by":3,"name":"Benjamin Meyer","email":"","orcid":"","institution":"","correspondingAuthor":false,"prefix":"","firstName":"Benjamin","middleName":"","lastName":"Meyer","suffix":""},{"id":377383547,"identity":"01197545-bf51-4f4b-b4cd-46db3ea2c440","order_by":4,"name":"Kenneth Yuen","email":"","orcid":"https://orcid.org/0000-0002-9465-9070","institution":"University Medical Center of the Johannes Gutenberg University Mainz","correspondingAuthor":false,"prefix":"","firstName":"Kenneth","middleName":"","lastName":"Yuen","suffix":""},{"id":377383548,"identity":"78545989-e476-4b5d-9bbf-1e6e36d6214b","order_by":5,"name":"Magdalena Storck","email":"","orcid":"","institution":"","correspondingAuthor":false,"prefix":"","firstName":"Magdalena","middleName":"","lastName":"Storck","suffix":""},{"id":377383549,"identity":"df0b839c-ecfb-4328-8380-cfdbb3fa7fa4","order_by":6,"name":"Oliver Tüscher","email":"","orcid":"","institution":"","correspondingAuthor":false,"prefix":"","firstName":"Oliver","middleName":"","lastName":"Tüscher","suffix":""}],"badges":[],"createdAt":"2024-10-01 23:25:07","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-5189916/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-5189916/v1","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1038/s41398-025-03786-6","type":"published","date":"2026-01-15T05:00:00+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":71724090,"identity":"73f31d1c-62db-4ada-b2ba-aa81fecfa378","added_by":"auto","created_at":"2024-12-18 05:40:34","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":239876,"visible":true,"origin":"","legend":"\u003cp\u003eExperimental procedure\u003c/p\u003e\n\u003cp\u003eNote. (a) Overview of the experimental procedure with MRI session including the psychosocial stress task ScanSTRESS-C on day 1 and the uncontrollability task on day 2. (b) ScanSTRESS-C with demonstration of the two cognitive tasks that had to be solved (mental rotation and subtraction) in noStress and stress blocks. Jury not watching in the noStress phase but watching and criticizing slow and inaccurate performance in stress blocks, additional time limit indicated by the colored bar. (c) Uncontrollability task with aversive stimulation that is supposedly terminated by correct arrow key presses in response to a geometric shape. Trial termination is unrelated to key presses, but variable trial lengths can create the illusion of control over stimulation. S1-S9: Saliva samples; R1-R5: Ratings of subjective experience; MDBF: multidimensional mood questionnaire; STADI-S: State-trait anxiety and depression inventory state version; PANAS: positive and negative affect scale, ITI: Inter trial interval. (b) Reprinted and adapted from Psychoneuroendocrinology, 118, Sandner, M., Lois, G., Streit, F., Zeier, P., Kirsch, P., Wüst, S., \u0026amp; Wessa, M., Investigating individual stress reactivity: High hair cortisol predicts lower acute stress responses. 104660, Copyright Elsevier Ltd. (2020), with permission from Elsevier.\u003c/p\u003e","description":"","filename":"1.png","url":"https://assets-eu.researchsquare.com/files/rs-5189916/v1/7e173e68fe43337a04074aaf.png"},{"id":71723160,"identity":"a2f2c2a9-a701-4488-bcea-2b5c32a68fc0","added_by":"auto","created_at":"2024-12-18 05:32:34","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":200370,"visible":true,"origin":"","legend":"\u003cp\u003ePredicted and observed trajectories of perceived control of the latent classes identified with GMM\u003c/p\u003e\n\u003cp\u003eNote. The best-fitting growth mixture model was a model with two latent classes. Estimated (a) and observed (b) trajectories of these classes differed in mean level of perceived control, resulting in a low-control and a high-control class. The low-control class had a negative slope, indicating that perceived control decreased even more over time for these participants.\u003c/p\u003e","description":"","filename":"2.png","url":"https://assets-eu.researchsquare.com/files/rs-5189916/v1/1776cd44d94cd8c34e67ef51.png"},{"id":71723159,"identity":"d24ef2ea-5512-4294-b48a-168cbdd4849d","added_by":"auto","created_at":"2024-12-18 05:32:34","extension":"png","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":137506,"visible":true,"origin":"","legend":"\u003cp\u003eClass differences in cortisol response to psychosocial stress\u003c/p\u003e\n\u003cp\u003eNote. Cortisol increase (a), total cortisol secretion (b), cortisol recovery (c) and mean cortisol reaction (d) in response to the ScanSTRESS-C task for the two perceived control classes derived from growth mixture modeling. Non-responders not included in plots a-c, errorbars denote bootstrapped 95% confidence intervals. Margins in (d) are standard deviations. AUC_i: Area under the curve with respect to increase, AUC_g: Area under the curve with respect to ground, n.s.: non-significant, * pHolm \u0026lt;.05.\u003c/p\u003e","description":"","filename":"3.png","url":"https://assets-eu.researchsquare.com/files/rs-5189916/v1/bcdc521cfe32a0312c448060.png"},{"id":71723162,"identity":"2d3556b4-bfce-42fa-a8f6-b50380248d3c","added_by":"auto","created_at":"2024-12-18 05:32:34","extension":"png","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":190108,"visible":true,"origin":"","legend":"\u003cp\u003eClass difference in neural response to psychosocial stress\u003c/p\u003e\n\u003cp\u003eNote: Significant clusters (a) and parameter estimates at peak voxels of posterior insula clusters (b) for the comparison of the low and high-class for the contrast stress\u0026gt;noStress. Activation maps are thresholded at p=.05 FWE-corrected on cluster-level and overlayed onto SPM152 template. lIns = left insula, rIns = right insula, *** p \u0026lt; .001.\u003c/p\u003e","description":"","filename":"4.png","url":"https://assets-eu.researchsquare.com/files/rs-5189916/v1/cc109424bb2a74555c222a4e.png"},{"id":100863266,"identity":"fced5569-1cf4-4cf9-9df1-c85def95e36d","added_by":"auto","created_at":"2026-01-22 08:05:53","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":839019,"visible":true,"origin":"","legend":"","description":"","filename":"Perceivedcontrolasaresiliencefactormanuscriptfinal.pdf","url":"https://assets-eu.researchsquare.com/files/rs-5189916/v1_covered_dca878d0-1881-457b-a24d-ccee04f92be0.pdf"},{"id":71723156,"identity":"329f2c88-d8ad-4f7d-90d0-48afab90d708","added_by":"auto","created_at":"2024-12-18 05:32:34","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":29353,"visible":true,"origin":"","legend":"\u003cp\u003eFigure S1: Manipulation checks\u003c/p\u003e\n\u003cp\u003eShows changes in self-reported affect and cortisol over the course of the experimental manipulations on testing days 1+2 for all participants (aggregated across perceived control classes). PDF-file.\u003c/p\u003e","description":"","filename":"FigureS1Manipulationchecks.pdf","url":"https://assets-eu.researchsquare.com/files/rs-5189916/v1/ca63fa1b366d531a5c2baccb.pdf"},{"id":71723158,"identity":"0e139256-41d6-4009-a638-790aac7fb210","added_by":"auto","created_at":"2024-12-18 05:32:34","extension":"pdf","order_by":2,"title":"","display":"","copyAsset":false,"role":"supplement","size":59812,"visible":true,"origin":"","legend":"\u003cp\u003eFigure S2: Differences between the perceived control classes in self-report measures\u003c/p\u003e\n\u003cp\u003ePlots of all outcomes included into the self-report MANOVA by perceived control class. Errorbars denote bootstrapped 95% confidence intervals. n.s.: non-significant, * pHolm \u0026lt; .05, ** pHolm \u0026lt; .01, *** pHolm \u0026lt; .001. PDF-file.\u003c/p\u003e","description":"","filename":"FigureS2Classdifferencesinselfreportmeasures.pdf","url":"https://assets-eu.researchsquare.com/files/rs-5189916/v1/a53e4dbc66654865424665e9.pdf"},{"id":71723161,"identity":"48811dd0-63af-493c-90af-cae4c583532e","added_by":"auto","created_at":"2024-12-18 05:32:34","extension":"pdf","order_by":3,"title":"","display":"","copyAsset":false,"role":"supplement","size":130141,"visible":true,"origin":"","legend":"\u003cp\u003eFigure S3: Neural response to the ScanSTRESS-C across classes\u003c/p\u003e\n\u003cp\u003eSignificant clusters for the effects of stress (a) and no stress (b) in the ScanSTRESS-C aggreagated across perceived control classes. Activation maps are thresholded at p=.05 FWE-corrected on peak-level and overlayed onto SPM152 template. PDF-file.\u003c/p\u003e","description":"","filename":"FigureS3NeuralresponsetoScanSTRESSCacrossclasses.pdf","url":"https://assets-eu.researchsquare.com/files/rs-5189916/v1/83631940f64627d7afb9f2e6.pdf"},{"id":71723163,"identity":"76e44ee2-39af-457f-a781-e9761b672e60","added_by":"auto","created_at":"2024-12-18 05:32:34","extension":"doc","order_by":4,"title":"","display":"","copyAsset":false,"role":"supplement","size":62976,"visible":true,"origin":"","legend":"\u003cp\u003eTable S1: Correlations of internal and external LoC with stress outcomes and mental health.\u003c/p\u003e\n\u003cp\u003eShows the correlations of all the outcomes reported in the paper with locus of control (LoC). No correlations are significant, indicating that perceived control classes better predict stress outcomes and mental health than LoC. Word-file.\u003c/p\u003e","description":"","filename":"TableS1CorrelationsofinternalandexternalLoCwithstressoutcomesandmentalhealth.doc","url":"https://assets-eu.researchsquare.com/files/rs-5189916/v1/668792a3e2834ae3b016df2d.doc"},{"id":71724091,"identity":"a72cf18c-dd8d-47ef-b307-4f5d2a988e23","added_by":"auto","created_at":"2024-12-18 05:40:34","extension":"doc","order_by":5,"title":"","display":"","copyAsset":false,"role":"supplement","size":82944,"visible":true,"origin":"","legend":"\u003cp\u003eTable S2: Significant clusters for stress effect in the ScanSTRESS-C\u003c/p\u003e\n\u003cp\u003eShows significant clusters activated and deactivated under the Stress vs. noStress conditions of the ScanSTRESS-C, aggregated across classes in the whole sample. Word-file.\u003c/p\u003e","description":"","filename":"TableS2SignificantclustersforthestresseffectintheScanSTRSSC.doc","url":"https://assets-eu.researchsquare.com/files/rs-5189916/v1/24e9edb2c2b5cbcb2a6a0c26.doc"},{"id":71723165,"identity":"849144c9-777b-4e3e-bf8d-3164a5fd4ea7","added_by":"auto","created_at":"2024-12-18 05:32:34","extension":"doc","order_by":6,"title":"","display":"","copyAsset":false,"role":"supplement","size":52736,"visible":true,"origin":"","legend":"\u003cp\u003eTable S3: Clusters differing significantly between the classes in the ScanSTRESS-C\u003c/p\u003e\n\u003cp\u003eShows clusters that significantly differ between the classes in the contrast Stress vs. noStress and the inverse contrast. Three clusters emerged. The low-control class shows increased activation of the bilateral posterior insula and the primary motor cortex under psychosocial stress. Word-file.\u003c/p\u003e","description":"","filename":"TableS3ClustersdifferingsignificantlybetweentheclassesintheScanSTRSSC.doc","url":"https://assets-eu.researchsquare.com/files/rs-5189916/v1/ae1460be35d4e17c9dd2cdf7.doc"}],"financialInterests":"The authors have declared there is \u003cb\u003eNO\u003c/b\u003e conflict of interest to disclose","formattedTitle":"Perceived control as a resilience factor: Influences on neural, physiological and affective stress responses and mental health","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"translational-psychiatry","isNatureJournal":false,"hasQc":false,"allowDirectSubmit":false,"externalIdentity":"tp","sideBox":"Learn more about [Translational Psychiatry](http://www.nature.com/tp/)","snPcode":"41398","submissionUrl":"https://mts-tp.nature.com/cgi-bin/main.plex","title":"Translational Psychiatry","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"ejp","reportingPortfolio":"Nature AJ","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"","lastPublishedDoi":"10.21203/rs.3.rs-5189916/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-5189916/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"Perceived control is a key mechanism implicated in stress resilience. A tendency to perceive control over stressors may protect individuals against negative outcomes across various situations by increasing active coping and preventing exacerbated stress reactions. Assuming that individual differences in perceived control during an uncontrollable stress task may represent an underlying resilience factor, we investigated associations of perceived control with neural, endocrine, and affective responses to a different, psychosocial stressor, and with overall mental health. 116 male participants aged 18-30 completed a psychosocial stress task, and we assessed stress responses via functional magnetic resonance imaging, cortisol levels, and affective state questionnaires. General mental health was assessed via self-report. Perceived control was measured during a second, uncontrollable stress task and growth mixture modeling revealed a high- and a low-control class. Comparison of these classes showed that the high-control class experienced less helplessness during the uncontrollability task and demonstrated more flexible responses to psychosocial stress as reflected in cortisol secretion and activation of the bilateral posterior insula. Further, the high-control class reported fewer psychosomatic symptoms and a less external locus of control. These findings suggest that perceived control acts as a resilience factor, influencing stress processing across multiple domains. The study highlights the potential for perceived control to be harnessed in resilience-building interventions and underscores the need for further experimental and longitudinal research to confirm its role in modulating stress responses.","manuscriptTitle":"Perceived control as a resilience factor: Influences on neural, physiological and affective stress responses and mental health","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-12-18 05:32:29","doi":"10.21203/rs.3.rs-5189916/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"transferred","content":"Translational Psychiatry","date":"2025-08-12T11:41:08+00:00","index":"","fulltext":""},{"type":"decision","content":"Reject after peer review","date":"2024-12-19T13:53:09+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"This content is not available.","date":"2024-12-16T20:08:21+00:00","index":3,"fulltext":"This content is not available."},{"type":"editorInvitedReview","content":"This content is not available.","date":"2024-11-28T21:05:17+00:00","index":1,"fulltext":"This content is not available."},{"type":"editorInvitedReview","content":"This content is not available.","date":"2024-11-21T12:58:16+00:00","index":2,"fulltext":"This content is not available."},{"type":"reviewerAgreed","content":"This content is not available.","date":"2024-11-19T19:47:53+00:00","index":3,"fulltext":"This content is not available."},{"type":"reviewerAgreed","content":"This content is not available.","date":"2024-11-14T07:49:45+00:00","index":2,"fulltext":"This content is not available."},{"type":"reviewerAgreed","content":"This content is not available.","date":"2024-11-13T05:37:47+00:00","index":1,"fulltext":"This content is not available."},{"type":"reviewersInvited","content":"","date":"2024-11-12T22:45:02+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2024-10-02T10:29:12+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2024-10-02T10:00:57+00:00","index":"","fulltext":""},{"type":"submitted","content":"Molecular Psychiatry","date":"2024-10-01T23:23:06+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"translational-psychiatry","isNatureJournal":false,"hasQc":false,"allowDirectSubmit":false,"externalIdentity":"tp","sideBox":"Learn more about [Translational Psychiatry](http://www.nature.com/tp/)","snPcode":"41398","submissionUrl":"https://mts-tp.nature.com/cgi-bin/main.plex","title":"Translational Psychiatry","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"ejp","reportingPortfolio":"Nature AJ","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"bd7395ad-69b1-43b6-a12e-c3e0f28d4b7e","owner":[],"postedDate":"December 18th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[{"id":40177910,"name":"Health sciences/Diseases/Psychiatric disorders/Depression"},{"id":40177911,"name":"Biological sciences/Neuroscience"},{"id":40177912,"name":"Biological sciences/Psychology"}],"tags":[],"updatedAt":"2026-01-22T08:05:46+00:00","versionOfRecord":{"articleIdentity":"rs-5189916","link":"https://doi.org/10.1038/s41398-025-03786-6","journal":{"identity":"translational-psychiatry","isVorOnly":false,"title":"Translational Psychiatry"},"publishedOn":"2026-01-15 05:00:00","publishedOnDateReadable":"January 15th, 2026"},"versionCreatedAt":"2024-12-18 05:32:29","video":"","vorDoi":"10.1038/s41398-025-03786-6","vorDoiUrl":"https://doi.org/10.1038/s41398-025-03786-6","workflowStages":[]},"version":"v1","identity":"rs-5189916","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-5189916","identity":"rs-5189916","version":["v1"]},"buildId":"qtupq5eGEP_6zYnWcrvyt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}