Clinical research of laparoscope surgery combined with GnRH-a in the treatment of moderate or severe endometriosis

Objective To investigate the efficacy and safety of laparoscope surgery combined with gonadotropin- releasing hormone agonist( GnRH- a) in the treatment of moderate or severe endometriosis. Methods Data of 82 patients with moderate to severe endometriosis in Xintai City People's Hospital from Jan to Dec. 2012 were collected,all cases were divided into GnRH- a group( 28 cases),oral contraceptive group( 28 cases) and surgery group( 26 cases) according to medication treatment before surgery. The indicators of preoperative and postoperative evaluation,pain visual analogue scale( VAS),recurrence rate and adverse reaction were compared among the three groups. Results The operative time,the amount of blood loss in GnRH- a group were lower than in those in the other two groups. The activity time and anal exhaust time in GnRH- a group were earlier than those in the other two groups( P 0. 05). After 12 months followed- up,the reduction of VAS in GnRH- a group was significantly higher than those in the other two groups. The recurrence rate in GnRH- a group was significantly lower than that in the other two groups( P 0. 05). 7patients with low estrogen hyperlipidemia occurred in GnRH- a group,the adverse effects could be tolerated. The symptoms were disappeared when medication treatment stopped. Normal menstruation retrieved for all patients after 4 months. Conclusion The laparoscopic surgery combined with preoperative GnRH- a in treatment of moderate to severe endometriosis can effectively improve surgical effects,which has advantages of fast postoperative recovery,low recurrence rate and safe.