Microalbumin and Diabetes mellitus type 2(T2DM): A Mendelian Randomization Study

Background: The observational link between microalbumin and type 2 diabetes (T2DM) is well established. However, it is uncertain if the link is causative. Methods: The current study performed Mendelian randomization (MR) on publicly accessible genome-wide association study (GWAS) summary data in order to investigate the causal linkages between microalbumin and T2DM. A single set of MR analyses was performed. As instrumental variables, a dataset of single nucleotide polymorphisms (SNPs) with significance value smaller than the genome-wide criteria (5*10 − 8) was employed. Results: The results suggested that microalbumin had a causal influence on T2DM risk based on the 0.05 threshold. Microalbumin was shown to be positively linked with the risk of T2DM using the inverse variance weighted (IVW) technique (OR = 1.346, 95% CI, 1.062–1.706, P = 0.014). The weighted median MR estimations revealed that microalbumin was positively associated with the incidence of T2DM (OR = 1.356, 95% CI, 1.038–1.771, P = 0.0254). Conclusions: The data showed that microalbumin may increase the incidence of T2DM dependent on the genome-wide statistical significance level. This study supports the notion that microalbumin has a negative causal influence on T2DM risk. Trial registration retrospectively registered.