PRESENT INSIGHTS INTO THE ETIOLOGY AND PATHOGENESIS OF MASTOPATHIES

PRESENT INSIGHTS INTO THE ETIOLOGY AND PATHOGENESIS OF MASTOPATHIES Authors/Creators - 1. Asia International University, Bukhara, Uzbekistan Description Mastopathy, also known as fibrocystic breast disease, is one of the most prevalent benign breast disorders in women of reproductive age. Despite its frequency, the etiology and pathophysiological mechanisms remain incompletely understood. This review synthesizes contemporary literature on the causes and mechanisms underlying mastopathy. Hormonal imbalance, particularly an elevated estradiol-to-progesterone ratio and increased prolactin activity, emerges as a central factor in disease development. Genetic predispositions, including polymorphisms in FSH receptor and estrogen receptor genes, are associated with higher susceptibility. Immune-mediated mechanisms, highlighted by lymphocytic infiltration, myofibroblast activation, and autoimmune links in diabetic mastopathy, further contribute to disease progression. Structural alterations in breast tissue, such as epithelial and stromal proliferation with fibrosis, are driven by hormonal and immunologic factors. Lifestyle and reproductive history also play modifying roles. Collectively, current evidence supports a multifactorial model of mastopathy involving endocrine, genetic, immunologic, and environmental influences. A deeper understanding of these mechanisms is critical for advancing diagnostic accuracy and developing more effective, targeted therapeutic strategies. Files 2359-2369.pdf Files (363.4 kB) | Name | Size | Download all | |---|---|---| | md5:9a7d06b6fa917dec0d2ab5c383f61fa0 | 363.4 kB | Preview Download | Additional details References - Brkić, M., Djaković, I., Tomić, S., & Bulajić, M. (2018). Hormonal profiles in women with fibrocystic breast changes. Medicinski Pregled, 71(3-4), 89–94. https://doi.org/10.2298/MPNS1804089B - Camuto, P. M., Zetrenne, E., & Ponn, T. (2000). Diabetic mastopathy: a report of 5 cases and a review of the literature. Archives of Surgery, 135(10), 1190–1193. https://doi.org/10.1001/archsurg.135.10.1190 - Chen, L., Zhou, J., Zhang, M., & Zhu, Y. (2018). Epidemiological and histopathological features of fibrocystic breast disease: A comprehensive review. International Journal of Clinical and Experimental Pathology, 11(2), 1215–1223. - 4.Chopra, S., Bharti, A., & Yadav, R. (2023). Hormonal imbalance in benign breast disease: An observational study. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 12(2), 356–361. https://doi.org/10.18203/2320-1770.ijrcog20230256 - Fraker, D. L., Patel, A., & Singh, A. (2023). Morphological changes and fibrotic pathways in mastopathy: A review. Journal of Breast Pathology, 45(2), 75–84.