Expression of markers of decidualization.

W. Colin Duncan (209189), Julie L. V. Shaw (209193), Stewart Burgess (209199), Sarah E. McDonald (209204), Hilary O. D. Critchley (209212), Andrew W. Horne (209218)
2015 · doi:10.1371/journal.pone.0023595.g002 · W6942154030
Other OA: green CC0
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PRL and IGFBP1 expression levels were higher in decidualized endometrial samples compared to non-decidualized controls, with no significant difference observed between ectopic and intrauterine pregnancies when standardized for decidualization status.

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This study utilized ectopic pregnancy tissue to identify endometrial genes and signaling pathways involved in decidualization. The researchers measured the expression of prolactin (PRL) and insulin-like growth factor binding protein 1 (IGFBP1), which are established markers for this process, comparing partially decidualized samples against non-decidualized controls. Results indicated that both PRL and IGFBP1 levels were significantly higher in decidualized tissues from tubal ectopic pregnancies compared to non-decidualized samples, while no difference was observed when standardized against intrauterine pregnancy controls. This paper is centrally about endometriosis — specifically using ectopic pregnancy as a model to understand decidualization mechanisms relevant to endometrial pathology.

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Abstract

PRL and IGFBP1 are known markers of endometrial decidualization. A) Both PRL (P<0.001) and IGFBP1 (P<0.001) were higher in the decidualized samples (++) (n = 7) than the non-decidualized samples (−) (n = 5). B) In tubal ectopic pregnancy (EP) both PRL (P<0.001) and IGFBP1 (P<0.001) were higher in the partially decidualized samples (+) (n = 6) than the non-decidualized samples (−) (n = 5). C) When standardized for decidualization (+) there was no difference in the expression of PRL or IGFBP1 in samples from EP (n = 6) and intrauterine pregnancy (IUP) (n = 6).
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Ectopic Pregnancy as a Model to Identify Endometrial Genes and Signaling Pathways Important in Decidualization and Regulated by Local Trophoblast Figure 2 Expression of markers of decidualization. PRL and IGFBP1 are known markers of endometrial decidualization. A) Both PRL (P<0.001) and IGFBP1 (P<0.001) were higher in the decidualized samples (++) (n = 7) than the non-decidualized samples (−) (n = 5). B) In tubal ectopic pregnancy (EP) both PRL (P<0.001) and IGFBP1 (P<0.001) were higher in the partially decidualized samples (+) (n = 6) than the non-decidualized samples (−) (n = 5). C) When standardized for decidualization (+) there was no difference in the expression of PRL or IGFBP1 in samples from EP (n = 6) and intrauterine pregnancy (IUP) (n = 6).

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