Deep Learning-Based Automated Segmentation of Uterine Myomas

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Abstract

Uterine fibroids (myomas) are the most common benign tumors of the female reproductive system, particularly among women of childbearing age. With a prevalence exceeding 70%, they pose a significant burden on female reproductive health. Clinical symptoms such as abnormal uterine bleeding, infertility, pelvic pain, and pressure-related discomfort play a crucial role in guiding treatment decisions, which are largely influenced by the size, number, and anatomical location of the fibroids. Magnetic Resonance Imaging (MRI) is a non-invasive and highly accurate imaging modality commonly used by clinicians for the diagnosis of uterine fibroids. Segmenting uterine fibroids requires a precise assessment of both the uterus and fibroids on MRI scans, including measurements of volume, shape, and spatial location. However, this process is labor intensive and time consuming and subjected to variability due to intra- and inter-expert differences at both pre- and post-treatment stages. As a result, there is a critical need for an accurate and automated segmentation method for uterine fibroids. In recent years, deep learning algorithms have shown re-markable improvements in medical image segmentation, outperforming traditional methods. These approaches offer the potential for fully automated segmentation. Several studies have explored the use of deep learning models to achieve automated segmentation of uterine fibroids. However, most of the previous work has been conducted using private datasets, which poses challenges for validation and comparison between studies. In this study, we leverage the publicly available Uterine Myoma MRI Dataset (UMD) to establish a baseline for automated segmentation of uterine fibroids, enabling standardized evaluation and facilitating future research in this domain.
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Method

achieved a mean Dice score of 0.70 for this class (Table I), highlighting its robustness in detecting and delineat- ing myomas across diverse cases. The large standard deviation reflects substantial case-to-case variability, as also visualized in Figure 3 where some cases exhibit Dice scores below 0.50, while some others exceed 0.80. This suggests that while the model can segment myomas accurately in favorable cases, challenges remain for cases with atypical morphology or low contrast. Such variability underscores the importance of further refinements, such as tailored post-processing or additional training data focused on difficult cases. Beyond myoma segmentation, the proposed method also performed impressively across other classes. It achieved Dice scores of 0.86 for the uterine wall, 0.79 for the uterine cavity, and 0.68 for the nabothian cyst (Table I), demonstrating the method’s ability to generalize across multiple classes. Notably, uterine wall segmentation was highly consistent across cases, as reflected by its low standard deviation and compact box plot distribution (Table I, Figure 3). In contrast, the lower and more variable scores for the nabothian cyst reflect expected challenges associated with its small size. Overall, the pro- posed method achieved a mean Dice score of 0.76 across all classes, validating its effectiveness as a powerful framework for uterine MRI segmentation. Crucially, its performance on myoma segmentation establishes a significant step forward in the development of automated tools for managing one of the most prevalent and burdensome conditions in women’s reproductive health. TABLE I DICE SCORES (MEAN ± STANDARD DEVIATION ) ON THE TEST SET . Label Dice Score Uterine Wall 0.86 ± 0.05 Uterine Cavity 0.79 ± 0.10 Myoma 0.70 ± 0.27 Nabothian Cyst 0.68 ± 0.38 Fig. 3. Dice Scores for uterine wall, uterine cavity, myoma and nabothian cyst on the test set. IV. C ONCLUSIONS In this study, we addressed the need for an automated and reproducible method for uterine myoma segmentation by leveraging a publicly available MRI dataset. The results demonstrate that our proposed method can reliably segment uterine myomas along with surrounding structures, offering a robust baseline for future research. This approach holds promise for reducing the clinical burden associated with manual segmentation and enabling more standardizeded as- sessment of myoma characteristics.

References

[1] M. M. McWilliams and V . M. Chennathukuzhi, “Recent advances in uterine fibroid etiology,” in Seminars in reproductive medicine , vol. 35, no. 02. Thieme Medical Publishers, 2017, pp. 181–189. [2] A. Tinelli, A. Morciano, R. Sparic, S. Hatirnaz, L. E. Malgieri, A. Mal- vasi, A. D’Amato, G. M. Baldini, and G. Pecorella, “Artificial intelligence and uterine fibroids: A useful combination for diagnosis and treatment,” Journal of Clinical Medicine , vol. 14, no. 10, p. 3454, 2025. [3] H. Pan, M. Chen, W. Bai, B. Li, X. Zhao, M. Zhang, D. Zhang, Y . Li, H. Wang, H. Genget al., “Large-scale uterine myoma mri dataset covering all figo types with pixel-level annotations,” Scientific Data, vol. 11, no. 1, p. 410, 2024. [4] F. Isensee, P. F. Jaeger, S. A. Kohl, J. Petersen, and K. H. Maier-Hein, “nnu-net: a self-configuring method for deep learning-based biomedical image segmentation,” Nature methods, vol. 18, no. 2, pp. 203–211, 2021.

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