CHRONIC ENDOMETRITIS IN WOMEN WITH PELVIC PAIN: DECODING PATHOGENESIS, ENHANCING DIAGNOSTICS, AND OPTIMIZING MULTIMODAL THERAPY

CHRONIC ENDOMETRITIS IN WOMEN WITH PELVIC PAIN: DECODING PATHOGENESIS, ENHANCING DIAGNOSTICS, AND OPTIMIZING MULTIMODAL THERAPY Authors/Creators - 1. Samarkand State Medical University Description Chronic endometritis silently fuels pelvic pain in women, undermining reproductive health, yet its pathogenesis and optimal management remain enigmatic. This study explores the microbial and immune underpinnings of chronic endometritis in reproductive-age women in Uzbekistan, leveraging advanced diagnostics and multimodal therapies. A cohort of 120 women with pelvic pain was assessed via clinical exams, molecular assays, ultrasound, and hysteroscopy, identifying pathogens and immune markers. Treatments combined antibiotics, probiotics, and hormonal agents, evaluated over 6 months. Results revealed 52% endometritis prevalence, driven by Chlamydia and Ureaplasma, with elevated IL-6 signaling inflammation. Multimodal therapy reduced pain by 70% and restored endometrial health in 75% of cases. In Uzbekistan’s youthful population, these findings spotlight endometritis as a treatable pain driver, offering global insights into fertility preservation through integrated care. Files 71-72.pdf Files (269.6 kB) | Name | Size | Download all | |---|---|---| | md5:6d7723bbcb2e52b22c27569ed96fa181 | 269.6 kB | Preview Download | Additional details References - 1. Cicinelli, E., Matteo, M., Tinelli, R., et al. (2015). Chronic endometritis and reproductive failure. Fertility and Sterility, 103(3), 674–679. DOI: 10.1016/j.fertnstert.2014.11.004 - 2. Howard, F. M. (2009). Chronic pelvic pain in women. American Journal of Obstetrics & Gynecology, 201(6), 536–543. DOI: 10.1016/j.ajog.2009.07.045 - 3. Moreno, I., Cicinelli, E., Garcia-Grau, I., et al. (2018). The diagnosis of chronic endometritis in infertile asymptomatic women: A comparative study of histology, microbial cultures, hysteroscopy, and molecular microbiology. American Journal of Obstetrics & Gynecology, 218(6), 602.e1–602.e16. DOI: 10.1016/j.ajog.2018.02.012 - 4. Kitaya, K., Matsubayashi, H., Yamaguchi, K., et al. (2016). Chronic endometritis: Potential cause of infertility and obstetric and neonatal complications. American Journal of Reproductive Immunology, 75(1), 13–22. DOI: 10.1111/aji.12438 - 5. McQueen, D. B., Perfetto, C. O., Hazard, F. K., & Lathi, R. B. (2015). Pregnancy outcomes in women with chronic endometritis and recurrent pregnancy loss. Fertility and Sterility, 104(4), 927–931. DOI: 10.1016/j.fertnstert.2015.06.044