Distribution Pattern of ER & PR Immunoexpression in Endometrial Biopsies of DUB and Infertile Patients from A Tertiary Care Centre

Endometrium, DUB, Infertility, Quick scoreAbstract

To study endometrial estrogen and progesterone immunoexpression in different phases of menstrual cycle, in cases of dysfunctional uterine bleeding and infertility. A comparative analysis was also done for calculating ER & PR expression, between two methods: quick score and percentage of immunopositive cells.

Endometrial biopsies from 107 clinically diagnosed DUB cases and 23 infertile patients were included in the study. Tissue sections were analyzed for different phases of menstrual cycle and immunoexpression of ER & PR receptors was calculated in glandular epithelium and stromal cells, using percentage of positively stained cells and Quick score method. Endometrial sections of hysterectomy specimens of uterovaginal prolapse cases were used as control sections.

In the present analysis, secretory endometrium was the commonest finding histopathologically. Mean total ER & PR expression in cases of DUB was statistically higher in the proliferative phase using both methods (p<0.05). Mean total ER expression difference in both the phases of infertility cases was not statistically significant by the observation of percentage of positively stained cells. However, quick score revealed significant difference between both receptor expression in infertile patients. Conclusion:The percentage of positive cells for ER and PR expression plays a more determinant role in studying ER and PR expression in cases of DUB and infertility as compared to quick score. DOI: 10.21276/APALM.1374

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