Synthesis of PVA/Fe3O4@SiO2@CPS@SID@Ni as novel magnetic fibrous composite polymer nanostructures and evaluation of anticancer and antimicrobal activity

Abstract Novel PVA/Fe3O4@SiO2@CPS@SID@Ni magnetic fibrous composite polymer (PVA/MFCP) were synthesized and its structure by Scanning Electron Microscopy (SEM), Fourier Transform Infrared spectroscopy (FT-IR), X-Ray Diffraction (XRD), Vibrating Sample Magnetometer (VSM), N2 adsorption/desorption isotherms and thermal behavior were confirmed. Anticancer properties of synthetic PVA/Fe3O4@SiO2@CPS@SID@Ni (MFCP) were evaluated by MTT method on MCF-7 breast cancer cells and IC50 119 µg/ml was observed at 48 hours. Antibacterial and antifungal properties of the synthesized MFCP nanostructures based on Minimum Inhibitory Concentration (MIC), Minimum Bactericidal Concentration (MBC) and Minimum Fungicidal Concentration (MFC) were tested and the results proved in some cases have better effect than commercial drugs.