OP31.09: Influence of endometriomas and deep infiltrating endometriosis on pregnancy outcome and first and second trimester markers of impaired placentation

The role of deep endometriosis (DIE) and ovarian endometrioma (E) as a risk factor for adverse perinatal outcomes in women with endometriosis has yet to be established. The aim of this study was to explore if fetal and maternal outcomes, in particular the incidence of small for gestational age (SGA) infants, are different in pregnant women with E versus DIP without endometrioma. This prospective included 160 pregnant women; 40 patients in each group with endometriosis, and 80 control cases of pregnant women without endometriosis. Women with uterine malformations, chronic hypertension, autoimmune diseases, pregnancy with major fetal structural abnormalities, aneuploidy or multiple gestations were excluded. DIE and E were diagnosed by using standardised ultrasonographic criteria. The study included patients who conceived spontaneously or by assisted reproductive techniques. The three groups were similar in demographic characteristics (age, body mass index, mode of conception). No statistically significant difference was found in patients with E and DEP without endometrioma regarding PAPP-A MoM (0.99 vs 1.17 MoM, p=0.211), mean uterine artery pulsatility index (UtA PI) in the 1st (1.70 vs 1.66, p=0.778) and 2nd (0.92 vs 0.94, p=0.779) trimester of pregnancy, and incidence of SGA (5% vs 7.5%, p=0.644; respectively). No statistically significant difference was found in patients with E and DEP without endometrioma when compared to those without endometriosis. Logistic regression analysis demonstrated that neither the presence of E nor the presence of DIP without endometrioma are independent risk factor for SGA. The presence of E and DIP without endometrioma are not risk factor for the delivery of SGA infants. Women with endometriosis should be treated in pregnancy as the general population and do not need a closer monitoring.