Relationship Between Body Mass Index and Serum Leptin in Patients With Endometriosis

Huali Wang

doi:10.3877/cma.j.issn.1673-5250.2012.05.020

Relationship Between Body Mass Index and Serum Leptin in Patients With Endometriosis

Huali Wang

In: Chung-Hua Fu Ch'an K'o Tsa Chih · 2012 · vol. 8(5) , pp. 623–625 · doi:10.3877/cma.j.issn.1673-5250.2012.05.020 · W3031697786

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This study of 52 women with endometriosis found that body mass index and serum leptin levels are significantly correlated, suggesting both factors play important roles in the occurrence and development of the disease.

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This study investigated the association between body mass index and serum leptin levels in 52 women with pathologically confirmed endometriosis, stratifying participants by disease stage into early (I-II) and advanced (III-IV) groups. The researchers found statistically significant differences in both BMI and serum leptin concentrations between the two stages, identifying a positive correlation where higher BMI was associated with elevated leptin levels. While the paper concludes that these factors play important roles in the occurrence and development of the disease, it relies on a relatively small sample size from a single institution. This paper is centrally about endometriosis — specifically examining metabolic and hormonal markers like leptin in relation to disease staging and severity.

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Abstract

Objective To investigate the relationship between body mass index (BMI) and serum leptin in patients with endometriosis. Methods From January 2007 to December 2010, A total of 52 women with endometriosis were included in the study, and divided into stage Ⅰ-Ⅱ group(n=26) and stage Ⅲ-Ⅳ group(n=26) according to postoperative pathohistological findings. Clinical features, BMI and serum leptin were compared between two groups, and the relationship between BMI and serum leptin was analyzed. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Dalian Obstetrics and Gynecology Hospital.Informed consent was obtained from each patients. Results There was no significant difference in clinical features such as age, menstrual cycle and symptoms between two groups(P>0.05). There had significant differences in both BMI and serum leptin between two groups(P<0.05), and positive correlation was found between BMI and serum leptin(r=0.30, P<0.05). The incidence rate of laparoscopic surgery in stage Ⅰ-Ⅱ group was obviously higher than that in stage Ⅲ-Ⅳ group(P<0.05). Conclusions BMI and serum leptin play important roles in the occurrence and development of endometriosis, and they have strong relationship. Key words: endometriosis; body mass index; leptin

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Objective

To investigate the relationship between body mass index (BMI) and serum leptin in patients with endometriosis.

Methods

From January 2007 to December 2010, A total of 52 women with endometriosis were included in the study, and divided into stage Ⅰ-Ⅱ group(n=26) and stage Ⅲ-Ⅳ group(n=26) according to postoperative pathohistological findings. Clinical features, BMI and serum leptin were compared between two groups, and the relationship between BMI and serum leptin was analyzed. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Dalian Obstetrics and Gynecology Hospital.Informed consent was obtained from each patients.

Results

There was no significant difference in clinical features such as age, menstrual cycle and symptoms between two groups(P>0.05). There had significant differences in both BMI and serum leptin between two groups(P<0.05), and positive correlation was found between BMI and serum leptin(r=0.30, P<0.05). The incidence rate of laparoscopic surgery in stage Ⅰ-Ⅱ group was obviously higher than that in stage Ⅲ-Ⅳ group(P<0.05).

Conclusions

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