THE QUANTITATIVE DETERMINNATION AND ANALYSIS OF CuZn-SOD AND MDA IN SERUM AND EPS OF PATIENTS WITH CHRONIC PELVIC PAIN SYNDROME

Objective To determine the levels of CuZn-SOD and MDA in serum and EPS in patients with chronic pelvic pain syndrome(CPPS) and explore their significance in the diagnosis and treatment of this condition. Methods Forty outpatients confirmed as having CPPS were divided into inflammatory group and non-inflammatory group and 20 healthy served as the control.Xanthine Oxidase method was applied to determine the content of CuZn-SOD and TBA method to determine the level of MDA.Results The levels of CuZn-SOD in serum among the three groups were not significantly different(P0.05).The serum levels of MDA in CPPS patients were significantly higher than that of the control(F=25.70;q=8.21,9.26;P0.01),but no significant difference was noted between the inflammatory and non-inflammatory group(P0.05).The vigour of CuZn-SOD in the EPS of the inflammatory group was markedly lower than that in the non-inflammatory group and the control(F=34.78;q=9.30,10.93;P0.01),but no significant difference was noted between the non-inflammatory group and the control(P0.05).The MDA in EPS of the inflammatory group was dramatically higher than that in the non-inflammatory and the control(F=441.63;q=35.73,37.03;P0.01),but no significant difference between the non-inflammatory and the control(P0.05). Conclusion The oxidative stress of EPS patients with inflammatory CPPS is stronger than that of the healthy adults,while there is no significant difference of the oxidative stress between patients with the non-inflammatory CPPS and the health young man.Measurements of the levels of CuZn-SOD and MDA,both in serum and EPS,can serve as valuable parameters in the diagnosis and assessment of the therapy of CPPS.