Studying-Polymers-On a-Chip (SPOC): High-throughput screening of polymers for battery applications

Studying-Polymers-On a-Chip (SPOC): High-throughput screening of polymers for battery applications | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Studying-Polymers-On a-Chip (SPOC): High-throughput screening of polymers for battery applications Johanna Schwartz, Jayvic Jimenez, Michell Marufu, Micah Silverman, and 16 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6164887/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Automated high-throughput screening is accelerating and changing the way we discover and design the world around us. High-throughput screening, in which robotic liquid and solid handling systems investigate chemical and material combinations, is critical to the next big leap in scientific advancement. Because high viscosity materials are difficult for liquid-handling screening systems, researchers in fields like polymer and composite chemistry still need to synthesize, mix, cast, and characterize formulations by hand, bottlenecking advancement. We created an automated high-throughput screening system that can mix, deposit, process, and measure polymer and composite formulations on-machine and in real-time, called Studying-Polymers-on-a-Chip (SPOC). To demonstrate SPOC’s potential, we screened over 224 solid polymer electrolyte formulations, 868 discrete samples, for lithium- and sodium-ion batteries, measuring ionic conductivity via an electrochemical impedance substrate array. We validated SPOC’s ability to reduce time and labor by comparing trends in ionic conductivities measured between our SPOC substrate and traditional coin cell testing. SPOC produced over 3.1 times more unique samples and over 3.7 times more measurements than we accomplished through coin cell testing. Ultimately, the automated and autonomous screening capabilities of SPOC project an increase of over six times the number of samples per year in one tenth the effort it would take scientists to do by hand, with Bayesian optimization approaches showing potential for even further acceleration. As such, SPOC offers a significant advancement in the ability to quickly and effectively identify materials and properties critical for the next generation of scientific applications. Physical sciences/Energy science and technology/Energy storage/Batteries Physical sciences/Chemistry/Materials chemistry/Soft materials/Polymers Physical sciences/Engineering/Mechanical engineering Physical sciences/Mathematics and computing/Scientific data Physical sciences/Materials science/Materials for energy and catalysis/Batteries Full Text Additional Declarations There is NO Competing Interest. Supplementary Files SPOCplatformSI.pdf Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6164887","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":432230548,"identity":"19613f25-4159-4d1c-9464-142933e8cd20","order_by":0,"name":"Johanna 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