The deferent changes of insulin-like growth factor I (IGF-1) and it's binding 3 (IGFBP3) on children of precocious puberty with enantone or danazol treatment

Objective: To explore the changes of concentration of serum insulin-like growth factor (IGF-1) and insulin-like growth factor binding protein Ⅲ (IGFBP-3) before and after drug treatment in patients with idiopathic central precocious puberty. Method: 18 children with precocious puberty were divided into two groups. The A group was treated with Enantone (n=9), and the B group was treated with Danazol (n=9). Result: Compared with that before treatment, the level of serum IGF-1 after treatment with Enantone was obviously descended, there was a significant difference (P 0.05); and there was no difference in the B group between pretreatment and post-treatment (P 0.05). The concentrations of IGFBP-3 didn't obviously change in two groups, there were no significant differences between those before and after treatment in two groups (P 0.05). Conclusion: (1)GH-IGF-1 axis can be inhibited with enatone while the sex development was slowed down, however, Danazol hasn't such fuctions. (2)The concentration of IGF-1 can be regarded as one of the monitors over the growth velocity after treatment with drug.