Effect of Compound Rhizoma Curcumae Powder on Expression of VEGF in Ectopic and Eutopic Endometrium of Patients with Endometriosis

Objective:To study the expression of vascular endothelial growth factor(VEGF) in ectopic and eutopic endometrium in patients with endometriosis and significance of the expression,and to study the effect of compound Rhizoma Curcumae powder on expression of VEGF in ectopic and eutopic endometrium in patients with endometriosis,the mechanism of compound Rhizoma Curcumae powder was explored in order to further clinical application.Method:Using immunohistochemistry SP method,the expression level of VEGF was detected in ectopic and eutopic endometrium in hospitalized patients with endometriosis,who had undertaken laparoscopic surgery in Department of Gynecology in Tianjin Nankai Hospital from July 2009 to January 2011,twenty-three cases were given compound Rhizoma Curcumae powder for 3 months before surgery(treatment group)and 30 cases without treatment entered endometriosis group,compared with that in endometrium from hysteromyoma patients of 30 cases(control group).Result:Expression of VEGF was significantly higher in eutopic endometrium of endometriosis group than that of control group(P0.05).Expression of VEGF in ectopic endometrium was lower than that in eutopic endometrium(P0.01) and was higher than that of control group(P0.05).The expression of VEGF in ectopic endometrium and eutopic endometrium in patients of treatment group were significantly lower than that in endometriosis group(P0.01).Conclusion:Significantly increased expression of VEGF in ectopic and eutopic endometrium in patients with endometriosis may be closely related to pathogenesis of endometriosis.Compound Rhizoma Curcumae powder may reduce the expression of VEGF in ectopic and eutopic endometrium in patients with endometriosis,thus it may play a therapeutic role in inhibiting angiogenesis in the endometrium.