The endometrial stem cell markers notch-1 and numb are associated with endometriosis

Schüring, Andreas N., Dahlhues, Beatrice, Korte, Anna, Kiesel, Ludwig, Titze, Ulf, Heitkötter, Birte, Ruckert, Christian, Martin Götte
2018 · doi:10.5281/zenodo.3695799 · W6949960877
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Endometrial expression of stem cell markers Notch-1 and Numb was significantly higher in endometriosis patients, particularly those with deep infiltrating endometriosis, supporting the stem cell hypothesis.

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This case–control study examined whether endometrial stem cell markers notch-1 and numb are associated with endometriosis by recruiting 51 endometriosis patients and 76 controls, all undergoing transcervical endometrial biopsy and diagnostic laparoscopy in an IVF unit and a tertiary referral center. Using immunostaining, the authors found that numb expression in the luminal epithelium of eutopic endometrium was higher in endometriosis patients than in controls (20.5% vs 16.5%, P=0.033), and that numb-positive single stromal cells were less frequent in endometrioma patients compared with other endometriosis forms. They also reported that notch-1 expression in endometrial glands was higher in patients with deep infiltrating endometriosis than in controls (39.1% vs 21.8%, P=0.045). The paper’s limitation is that it is observational and evaluates associations rather than establishing causality. This paper is centrally about endometriosis — it investigates how notch-1 and numb expression in eutopic endometrium relates to endometriosis presence and clinical subtypes.

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Abstract

Previous studies reported increased expression of the notch pathway-associated protein Musashi-1 in endometriosis. This case–control study investigates an association of the endometrial stem cell markers notch-1 and numb with endometriosis. Fifty-one endometriosis patients and 76 controls were recruited in the IVF unit and tertiary endometriosis referral centre of a university hospital. All subjects underwent transcervical endometrial biopsy and diagnostic laparoscopy. Expression of endometrial notch-1 and numb was assessed by immunostaining and correlated with clinical data. Association of stem-cell-marker expression with the presence of endometriosis was evaluated. Numb expression in the luminal epithelium was significantly higher in eutopic endometrium of endometriosis patients compared with controls (20.5% versus 16.5%, P = 0.033). Numb-positive single stromal cells were less frequent in endometrioma patients compared with other forms of endometriosis (0.3 versus 0.5 cells/visual field; P = 0.028). Notch-1 expression in endometrial glands was significantly higher in patients with deep infiltrating endometriosis compared with controls (39.1% versus 21.8%; P = 0.045). We conclude that stem cell markers notch-1 and numb of eutopic endometrium are associated with endometriosis and its clinical presentations, supporting the stem cell hypothesis of endometriosis. These findings could help develop promising research strategies applying endometrial stem cells as novel tools.
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The endometrial stem cell markers notch-1 and numb are associated with endometriosis Authors/Creators - 1. Department of Gynaecology and Obstetrics, University Hospital of Münster, 48149 Münster, Germany - 2. Gerhard-Domagk-Institute of Pathology, University Hospital of Münster, 48149 Münster, Germany - 3. Institute of Biometry and Statistics, University Hospital of Münster, 48149 Münster, Germany Description Previous studies reported increased expression of the notch pathway-associated protein Musashi-1 in endometriosis. This case–control study investigates an association of the endometrial stem cell markers notch-1 and numb with endometriosis. Fifty-one endometriosis patients and 76 controls were recruited in the IVF unit and tertiary endometriosis referral centre of a university hospital. All subjects underwent transcervical endometrial biopsy and diagnostic laparoscopy. Expression of endometrial notch-1 and numb was assessed by immunostaining and correlated with clinical data. Association of stem-cell-marker expression with the presence of endometriosis was evaluated. Numb expression in the luminal epithelium was significantly higher in eutopic endometrium of endometriosis patients compared with controls (20.5% versus 16.5%, P = 0.033). Numb-positive single stromal cells were less frequent in endometrioma patients compared with other forms of endometriosis (0.3 versus 0.5 cells/visual field; P = 0.028). Notch-1 expression in endometrial glands was significantly higher in patients with deep infiltrating endometriosis compared with controls (39.1% versus 21.8%; P = 0.045). We conclude that stem cell markers notch-1 and numb of eutopic endometrium are associated with endometriosis and its clinical presentations, supporting the stem cell hypothesis of endometriosis. These findings could help develop promising research strategies applying endometrial stem cells as novel tools. Files Preprint Version_Schüring_2018_MOMENDO.pdf Files (431.0 kB) | Name | Size | Download all | |---|---|---| | md5:dc7eebdad45be852ab537f21dc2d0e36 | 431.0 kB | Preview Download | Additional details Related works - Is cited by - 29398419 (PMID) - Is previous version of - Journal article: 10.1016/j.rbmo.2017.11.010 (DOI)

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