Pseudohypertestosteronemia during danazol therapy. A case report.

E J Miller, Miller EJ, Coleman FH, F H Coleman
The Journal of reproductive medicine · 1990 · vol. 35(6) , pp. 661–2 · PMID:2359064 · W2467305266
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Danazol therapy can cause false elevations in serum testosterone due to cross-reactivity, leading to apparent virilization which resolves upon drug discontinuation.

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Abstract

Several steroid radioimmunoassay kits, particularly testosterone, cross-react with danazol, producing false elevations of serum steroid levels. A patient taking danazol simultaneously developed signs of virilization and an apparent 15-fold elevation in her serum testosterone. Discontinuation of danazol resulted in a prompt return to physical and biochemical normality.

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Condition tags

endometriosis

MeSH descriptors

Danazol Endometriosis Pregnadienes Testosterone Uterine Neoplasms Virilism Adult Danazol Danazol Endometriosis Female Humans Pregnadienes Radioimmunoassay Testosterone Uterine Neoplasms Virilism

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europepmc
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openalex
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License: CC0 · commercial use OK