Influence of grasp context-dependent uncertainty on sensorimotor integration during object manipulation is independent of stimulus history

Influence of grasp context-dependent uncertainty on sensorimotor integration during object manipulation is independent of stimulus history | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Influence of grasp context-dependent uncertainty on sensorimotor integration during object manipulation is independent of stimulus history Swarnab Dutta, Varadhan SKM This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6339406/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 24 Oct, 2025 Read the published version in Scientific Reports → Version 1 posted 11 You are reading this latest preprint version Abstract Anticipatory control during dexterous object manipulation has been shown to operate around a dichotomy of largely feedback or feedforward grip force modulation, depending on whether the choice of contact points is allowed or not. This study explores how a binary uncertainty about the grasp context during movement preparation affects the balance of these predictive mechanisms in sensorimotor integration. We probed predictive control through a manipulation task requiring anticipatory moment compensation to minimise object roll for an asymmetrical weight distribution. Our previous work had shown that such pre-movement uncertainty about the grasp context elicited kinetic signatures during the loading phase, insofar as altering the normative relative contribution of feedforward vs. feedback force control. Building on these findings, in this paper we analysed the role of the distribution of prior stimuli on the influence of this uncertainty within the framework of motor planning. Despite our expectations that participants would modulate their reliance on sensory feedback based on stimulus history, the findings showed evidence against such history-dependent modulation. This outcome suggests two possibilities, that the participants either refrained from internalising the temporal structure of the uncertainty, or they dissociated learning of the stimulus structure from sensorimotor integration to avoid motor errors. Biological sciences/Neuroscience Biological sciences/Psychology Physical sciences/Engineering/Biomedical engineering Anticipatory control sensorimotor memories motor planning uncertainty feedforward vs feedback object manipulation event distribution stimulus history Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Published Journal Publication published 24 Oct, 2025 Read the published version in Scientific Reports → Version 1 posted Editorial decision: Revision requested 17 Jun, 2025 Reviews received at journal 06 Jun, 2025 Reviewers agreed at journal 23 May, 2025 Reviews received at journal 12 May, 2025 Reviewers agreed at journal 06 May, 2025 Reviewers agreed at journal 15 Apr, 2025 Reviewers invited by journal 10 Apr, 2025 Editor assigned by journal 10 Apr, 2025 Editor invited by journal 10 Apr, 2025 Submission checks completed at journal 07 Apr, 2025 First submitted to journal 30 Mar, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6339406","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":442367271,"identity":"4ec1a155-34be-49b7-9248-35d53460209e","order_by":0,"name":"Swarnab Dutta","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAABBUlEQVRIiWNgGAWjYFACxsYHPBUSPPwgdkIBAw8bVJwHtxbmZgOeMzYykg0gLQZALWwEtbC3SfC2pdkYHABxDICYDbdaMOCfdrDZ4A3bYR7j86cTPzwwYJDhk+9OYPhRwyBjjkOLxO3ExodzeA7zmN3I3SwBcRjvBsaeYww8lg049NxObDbmkQBp4d0A18LA28DAA3EqJpC/ndgmzWMAdFj/2c0/4Lb8xaPFAKwlIY3HgCF3G9wWZny2GAIdZjjngA2PxI3cbRYJBhJALbkbDssck8CpRe52+sMHb/9J2PMDHXbzR4WNvXzz2Y0P39TY2OPSgg4kwOQBGGMUjIJRMApGAXkAACUnUvpGQuYHAAAAAElFTkSuQmCC","orcid":"","institution":"Indian Institute of Technology Madras","correspondingAuthor":true,"prefix":"","firstName":"Swarnab","middleName":"","lastName":"Dutta","suffix":""},{"id":442367272,"identity":"75214630-b295-4120-96e1-1d082040b78b","order_by":1,"name":"Varadhan SKM","email":"","orcid":"","institution":"Indian Institute of Technology Madras","correspondingAuthor":false,"prefix":"","firstName":"Varadhan","middleName":"","lastName":"SKM","suffix":""}],"badges":[],"createdAt":"2025-03-30 15:53:15","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-6339406/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-6339406/v1","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1038/s41598-025-20153-z","type":"published","date":"2025-10-24T16:17:02+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":94490594,"identity":"e2449d88-240e-42e8-a06c-1f849f592433","added_by":"auto","created_at":"2025-10-27 17:12:48","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1089678,"visible":true,"origin":"","legend":"","description":"","filename":"Historyeffectsfinal.pdf","url":"https://assets-eu.researchsquare.com/files/rs-6339406/v1_covered_1155f1ea-8b70-4b10-b1d7-2f4f55d1427a.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Influence of grasp context-dependent uncertainty on sensorimotor integration during object manipulation is independent of stimulus history","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"scientific-reports","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"scirep","sideBox":"Learn more about [Scientific Reports](http://www.nature.com/srep/)","snPcode":"","submissionUrl":"","title":"Scientific Reports","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"Scientific Reports","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"Anticipatory control, sensorimotor memories, motor planning, uncertainty, feedforward vs feedback, object manipulation, event distribution, stimulus history","lastPublishedDoi":"10.21203/rs.3.rs-6339406/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-6339406/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eAnticipatory control during dexterous object manipulation has been shown to operate around a dichotomy of largely feedback or feedforward grip force modulation, depending on whether the choice of contact points is allowed or not. 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