Effect of half-dose GuRH-a on endometriosis

Objective To investigate the effect of half-dose GuRH-a on endometriosis.Methods Forty-one patients with endometriosis underwent laparoscopic conservative operation were randomly divided into traditional dose group(21cases),with intramuscular injection of diphereline 3.75 mg,once every four weeks for 6 times,and half-dose group,with intramuscular injection of diphereline 1.9 mg,once every four weeks for 6 times.Results The symptom of dysmenorrhea in both two groups relieved in different degrees.Twelve weeks after treatment,the patients received gynecologial examination and the tenderness in pelvic disappeared in both groups.Anal expansion relieved in most patients.The clinical remission rate of the traditional dose group was 87.1％,while that of the half-dose group was 86.3％,there was no significanct difference (P ＞ 0.05).Checked by type-B ultrasound,the recurrence rate of the traditional dose group was 4.8％,while that of the half-dose group was 5％,there was no significant difference (P ＞ 0.05).Obvious low estrogen symptoms like afternoon fever and hyperhidrosis occurred in 78.6％ of the traditional dose group,while no such symptoms occurred in the half-dose group,and there was significant difference (P ＜ 0.01).Conclusions It is safe and effective to use half-dose GuRH-a for treating endometriosis.The half-dose treatment method can obtain the same effect as the traditional dose treatment,and decrease the side effects. Key words: GuRH-a;  Endometriosis ;  Half-dose