Endometriosis is an Oestrogen-Dependent Autoimmune Disorder in Genetically Prone Women

Kanchana Devi Balakrishnan; N Pandiyan; Pandiyan Natarajan

doi:10.25259/fsr_2_2024

Endometriosis is an Oestrogen-Dependent Autoimmune Disorder in Genetically Prone Women

Kanchana Devi Balakrishnan, N Pandiyan, Pandiyan Natarajan

In: Fertility Science and Research · 2024 · vol. 11 , pp. 3 · doi:10.25259/fsr_2_2024 · W4396738193

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Abstract

Endometriosis affects 10% of the population. It has a chronic course presenting with pelvic pain, pelvic lesions, subfertility and psychological issues in the affected individual. The existing treatments, like drugs to induce a hypoestrogenic state and the surgical methods of clearing adhesions and removing endometriotic cysts, are not fully effective in preventing the recurrence or restoring fertility. Emerging knowledge on the immunological basis of endometriosis, its association with co-morbidities like autoimmune disorders and the probable genetic association of these disorders with other pain conditions will help in steering research towards finding effective preventive strategies and restoring fertility.