Key role of EGFR, ErbB2 and PR proteins in gene and protein interactions with Vimentin, FOXC1/2, FAK, and the BRCA1 in prevention of triple negative breast cancer

Key role of EGFR, ErbB2 and PR proteins in gene and protein interactions with Vimentin, FOXC1/2, FAK, and the BRCA1 in prevention of triple negative breast cancer | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Key role of EGFR, ErbB2 and PR proteins in gene and protein interactions with Vimentin, FOXC1/2, FAK, and the BRCA1 in prevention of triple negative breast cancer eswari beeram, B. Samba Sivaiah, Swetha Madamala, Shabana Palyam This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8416470/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Studies on protein–protein interactions and RNA–protein interactions between transcription factors and receptors that act as tumor suppressor proteins play key roles in designing new anticancer drugs for treatment. The BRCA1 RING domain exhibits protein–protein interactions with Vimentin, FOXC2, Focal adhesion kinase and EGFR, whereas the EGFR nucleic acid contig shows gene–protein interactions with Vimentin, FOXC2, Focal adhesion kinase and BRCA1. ErbB2 and the progesterone receptor play key roles in protein–protein interactions with the BRCA1 RING domain and ErB2 in TNBC, and the PR nucleic acid contig shows gene–protein interactions with vimentin, FOXC2, focal adhesion kinase and the BRCA1 RING domain, clearly indicating that the transaction of proteins occurs mostly although noncovalent interactions. Biological sciences/Cancer/Breast cancer Biological sciences/Cancer/Cancer prevention BRCA1 RING domain Vimentin FOXC2 Focal adhesion kinase and BRCA1 Protein–protein interactions Gene–protein interactions Full Text Additional Declarations There is NO conflict of interest to disclose. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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