Higher CRHR1 and CRHR2 expression in eutopic endometrium of endometriotic women at an mRNA and protein level.

Aikaterini Vergetaki (406454), Udo Jeschke (61955), Thomas Vrekoussis (406455), Eirini Taliouri (406456), Luca Sabatini (406457), Evangelia A. Papakonstanti (34242), Antonis Makrigiannakis (406458)
2015 · doi:10.1371/journal.pone.0062313.g002 · W6885604523
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CRHR1 and CRHR2 mRNA and protein expression were significantly higher in the eutopic endometrium of women with endometriosis compared to healthy controls.

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⚙ AI-generated deep summary by claude@2026-07, 2026-07-16 · read from full text ⓘ

The study compared expression of corticotropin-releasing hormone family components (CRH, urocortins, and their receptors CRHR1 and CRHR2) between eutopic and ectopic endometrium from women with endometriosis and eutopic endometrium from healthy controls. Using mRNA measurements and protein analysis, the authors found that CRHR1 and CRHR2 were higher in eutopic endometrium of endometriotic women than in eutopic endometrium of healthy women at both the transcript and protein levels. The main limitation explicitly suggested by the presented figure is that the protein results are based on representative data rather than detailing broader quantification across all samples in the provided text. This paper is centrally about endometriosis — it reports increased CRHR1 and CRHR2 expression in eutopic endometrium of endometriotic women.

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Abstract

A: mRNA expression of CRHR1β(554 bps) and CRHR2α(322 bps) is higher in eutopic endometrium of endometriotic women(ee) compared to eutopic endometrium of healthy women(he). B: protein expression of CRHR1 (55 kDa) and CRHR2 (55 kDa) is higher in ee compared to he. (**p<0.01) (representative data).
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Differential Expression of CRH, UCN, CRHR1 and CRHR2 in Eutopic and Ectopic Endometrium of Women with Endometriosis Figure 2 Higher CRHR1 and CRHR2 expression in eutopic endometrium of endometriotic women at an mRNA and protein level. A: mRNA expression of CRHR1β(554 bps) and CRHR2α(322 bps) is higher in eutopic endometrium of endometriotic women(ee) compared to eutopic endometrium of healthy women(he). B: protein expression of CRHR1 (55 kDa) and CRHR2 (55 kDa) is higher in ee compared to he. (**p<0.01) (representative data).

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