Optimum design of a biodegradable implant for femoral shaft fracture fixation using finite element method.

Optimum design of a biodegradable implant for femoral shaft fracture fixation using finite element method. | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Optimum design of a biodegradable implant for femoral shaft fracture fixation using finite element method. Sina Taghipour, Farid Vakili Tahami, Akbar Allahverdizadeh This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4769010/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 18 Jun, 2025 Read the published version in Physical and Engineering Sciences in Medicine → Version 1 posted 6 You are reading this latest preprint version Abstract Recent developments in biodegradable implant technology have expanded its use in several medical fields, such as orthopedics, cardiology, dentistry, and tissue engineering. Degradable bone-fixing implants have shown favorable results among others. Degradable implants, consisting of a plate and screws, provide the advantage of completely degrading after efficaciously supporting the broken bone for the required duration. They may even provide nutrients that accelerate the healing process while ensuring sufficient mechanical stability. Magnesium alloys are being considered by researchers as promising options for bone implants due to their natural degradability, good biocompatibility, and ability to lower the chances of long-term complications. The rapid corrosion rate and inferior mechanical properties of magnesium relative to non-biodegradable materials are significant challenges in their clinical usage as implant material. This leads to a loss of structural strength before the broken bone completely heals. Hence This article mainly concentrates on the design of a biodegradable implant plate for a femoral shaft fracture in the walking cycle, considering the plate's dimension, number of screws, biodegradation rate, and sufficient mechanical stability. Using the results of the numerical analyses, the safe zone of the implant plate design is determined based on the implant plate stress and the total displacement of the femur bone. Then, the optimum topology of the plate and appropriate number of screws are determined. Biodegradable materials Implant plate Femoral shaft fracture Topology optimization Full Text Supplementary Files declarationStatement1.docx Cite Share Download PDF Status: Published Journal Publication published 18 Jun, 2025 Read the published version in Physical and Engineering Sciences in Medicine → Version 1 posted Editorial decision: Major revisions 01 Feb, 2025 Reviewers agreed at journal 06 Aug, 2024 Reviewers invited by journal 29 Jul, 2024 Editor invited by journal 24 Jul, 2024 Editor assigned by journal 20 Jul, 2024 First submitted to journal 19 Jul, 2024 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4769010","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":333439893,"identity":"3fd5005d-7fde-483f-bfd1-ba295a8ce69e","order_by":0,"name":"Sina Taghipour","email":"data:image/png;base64,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","orcid":"","institution":"University of Tabriz","correspondingAuthor":true,"prefix":"","firstName":"Sina","middleName":"","lastName":"Taghipour","suffix":""},{"id":333439894,"identity":"26b42981-d5e1-4fe3-952b-0210527c821c","order_by":1,"name":"Farid Vakili Tahami","email":"","orcid":"","institution":"University of Tabriz","correspondingAuthor":false,"prefix":"","firstName":"Farid","middleName":"Vakili","lastName":"Tahami","suffix":""},{"id":333439895,"identity":"a9fd589e-aa59-4399-bae3-d92f79568ce3","order_by":2,"name":"Akbar Allahverdizadeh","email":"","orcid":"","institution":"University of Tabriz","correspondingAuthor":false,"prefix":"","firstName":"Akbar","middleName":"","lastName":"Allahverdizadeh","suffix":""}],"badges":[],"createdAt":"2024-07-19 18:08:36","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-4769010/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-4769010/v1","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1007/s13246-025-01562-w","type":"published","date":"2025-06-18T15:57:57+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":85231426,"identity":"4e47d23f-3fdf-4aae-b5a2-07dc457a1b44","added_by":"auto","created_at":"2025-06-23 16:07:50","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1261749,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript01.pdf","url":"https://assets-eu.researchsquare.com/files/rs-4769010/v1_covered_23d7c91f-1a74-49d3-a5f0-eb389398aa8b.pdf"},{"id":63268816,"identity":"e597967e-c3c5-4eb5-8a98-154f18dbe301","added_by":"auto","created_at":"2024-08-26 10:48:00","extension":"docx","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":13500,"visible":true,"origin":"","legend":"","description":"","filename":"declarationStatement1.docx","url":"https://assets-eu.researchsquare.com/files/rs-4769010/v1/4bd95bf7e7702376e5465d6f.docx"}],"financialInterests":"","formattedTitle":"Optimum design of a biodegradable implant for femoral shaft fracture fixation using finite element method.","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":true,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"physical-and-engineering-sciences-in-medicine","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"apes","sideBox":"Learn more about [Physical and Engineering Sciences in Medicine](http://link.springer.com/journal/13246)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/apes/default.aspx","title":"Physical and Engineering Sciences in Medicine","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"Springer Hybrid","inReviewEnabled":true,"inReviewRevisionsEnabled":false},"keywords":"Biodegradable materials, Implant plate, Femoral shaft fracture, Topology optimization","lastPublishedDoi":"10.21203/rs.3.rs-4769010/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4769010/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eRecent developments in biodegradable implant technology have expanded its use in several medical fields, such as orthopedics, cardiology, dentistry, and tissue engineering. 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