Meta-analysis for the Effect and Side Effect of Gestrinone

Objective:To evaluate the value of gestrinone in the treatment of endometriosis(EMs).Methods:We searched OVID,MEDLINE and CNKI for RCTs.This meta-analysis is performed based on Cochrane Handbook for Systematic Reviews of Interventions.Results:Gestrinone has better curative effect compared with marvelon(RR=8.270,95%CI:1.046-65.384),but its efficiency is inferior to GnRHa(RR=0.888,95%CI:0.845-0.933),danazol(RR=1.043,95%CI:0.949-1.146),mifepristone(RR=0.972,95%CI:0.943-1.003) and traditional Chinese medicine(RR=0.954,95%CI:0.905-1.006) show no difference from gestrinone in efficiency.Gestrinone and mifepristone(RR=0.913,95%CI:0.730-1.140) have equal pregnancy rate,but more women get pregnant after treated by GnRHa when compared with that by gestrinone(RR=0.792,95%CI:0.657-0.954).Gestrinone shows a higher incidence of side effect(liver dysfunction) than mifepristone(RR=1.865,95%CI:1.453-2.394) and marvelon(RR= 8.270,95%CI:1.046-65.384),but there is no difference when compared with GnRHa(RR=1.308,95%CI:0.965-1.772).The AFS scores of two dosage regimens of gestrinone are the same(SMD=0.185,95%CI:-0.491-0.861).Conclusions:As a secondline drug for treating EMs,the effeciency of gestrinone is inferior to GnRHa.Increasing the dosage shows no improvement on efficiency.It′s still an option when the side effects are tolerable.