Chemically induced deceleration of nuclear spin relaxation (CIDER) preserves hyperpolarization

Chemically induced deceleration of nuclear spin relaxation (CIDER) preserves hyperpolarization | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Chemically induced deceleration of nuclear spin relaxation (CIDER) preserves hyperpolarization Josh Peters, Charbel Assaf, Arne Brahms, Kolja Them, Mirco Gerdsen, and 3 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4668036/v2 This work is licensed under a CC BY 4.0 License Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Abstract Gadolinium-based contrast agents have revolutionized MRI by accelerating spin relaxation. Agents that decelerate relaxation, however, were hitherto unknown. Such agents would be of great interest, e.g., for metabolic imaging with hyperpolarized tracers (e.g., 15 N-pyridine, [1,4- 13 C 2 ]succinate, [1- 15 N]nicotinamide), where precious polarization, sometimes completely, is lost, e.g., during the transfer from the polarizer to the scanner. Here, we report on a previously unreported effect where tracers' longitudinal and transverse relaxation rates in aqueous solution are substantially reduced by adding biocompatible molecules such as nicotinamide, urea, glycerol, or dendrons. The impact on longitudinal relaxation is particularly effective in low magnetic fields and near pKa where T 1 was tripled. The effect substantially reduces the polarization loss during transfer, so hitherto unsuitable, fast-relaxing molecules can be used now. This way, we achieved the highest reported 15 N hyperpolarization of nearly 30% for [1- 15 N]nicotinamide. This chemically induced deceleration of nuclear spin relaxation (CIDER) effect was confirmed using magnetic-field-cycling experiments and has broad potential applications in hyperpolarized MR and beyond. Physical sciences/Chemistry/Physical chemistry/Chemical physics Physical sciences/Chemistry/Medicinal chemistry/Drug discovery and development Physical sciences/Chemistry/Analytical chemistry/NMR spectroscopy/Solution-state NMR Physical sciences/Chemistry/Organic chemistry/Reaction mechanisms hyperpolarization molecular MRI nicotinamide DNP dynamic nuclear polarization 15N relaxation rapid chemical exchange Full Text Additional Declarations The authors declare potential competing interests as follows: A patent with regard to the data presented in this work has been filed (EP 24185510). Supplementary Files CIDERsupportinginformation.docx Supporting information to the main mauscript Cite Share Download PDF Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4668036","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":325807501,"identity":"59de4b91-8879-4e03-bfdb-66f1cbb77ed5","order_by":0,"name":"Josh Peters","email":"","orcid":"https://orcid.org/0000-0003-1019-4067","institution":"Section Biomedical Imaging, University Medical Center Kiel, Kiel University","correspondingAuthor":false,"prefix":"","firstName":"Josh","middleName":"","lastName":"Peters","suffix":""},{"id":325807502,"identity":"8aee79ec-eecf-426f-b94b-12e79cb8c18b","order_by":1,"name":"Charbel 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