selscape: A Snakemake Workflow for Investigating Genomic Landscapes of Natural Selection

Abstract Analyzing natural selection is a central task in evolutionary genomics, yet applying multiple tools across populations in a reproducible and scalable manner is often complicated by heterogeneous input formats, parameter settings, and tool dependencies. Here, we present selscape, a Snakemake workflow that automates end-to-end genome-wide selection analysis—from input preparation and statistic calculation to functional annotation, downstream visualization, and summary reporting. We demonstrate selscape on high-coverage genomes from the 1000 Genomes Project, illustrating how the workflow enables efficient, large-scale analyses and streamlined comparisons across populations. By unifying diverse tools with Snakemake, selscape lowers the barrier to robust genome-wide analyses and provides a flexible framework for future extensions and integration with complementary population genetic analyses. Competing Interest Statement The authors have declared no competing interest.