Combatting Skin Aging with Chinese Herbal Medicine: Insights into SIRT1/NRF2 Pathway Regulation

Combatting Skin Aging with Chinese Herbal Medicine: Insights into SIRT1/NRF2 Pathway Regulation | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 24 April 2025 V1 Latest version Share on Combatting Skin Aging with Chinese Herbal Medicine: Insights into SIRT1/NRF2 Pathway Regulation Authors : Yi Liu , Dongsheng Shang 0000-0002-8523-8901 , and Zhigang Tu [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.174550684.46199193/v1 227 views 97 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Skin aging arises from the complex interplay between intrinsic senescence and extrinsic stressors, particularly ultraviolet (UV) radiation, leading to accumulated senescent cells with characteristic cell cycle arrest, senescence-associated secretory phenotype (SASP) secretion, and metabolic dysfunction. This review elucidates how the interconnected SIRT1/NRF2 axis serves as a central regulator of cutaneous aging - where SIRT1 orchestrates mitochondrial homeostasis and inflammation control through deacetylation of p53, FoxOs, and PGC-1α, while NRF2 masterfully coordinates antioxidant responses via KEAP1 dissociation and ARE activation. Crucially, their crosstalk enhances autophagic clearance and redox balance. Traditional Chinese Medicine provides diverse phytochemicals targeting this axis: galangin and oroxylin A activate SIRT1-mediated pathways; corylin and sulforaphane directly modulate NRF2; while cryptotanshinone and zerumbone exhibit dual-pathway regulation with additional AP-1 inhibition. These compounds, derived from phylogenetically distinct plants, demonstrate functional convergence in mitigating oxidative damage, suppressing inflammation, and maintaining extracellular matrix integrity. Particularly noteworthy is their multi-target capacity - exemplified by salvianolic acid B’s simultaneous enhancement of mitochondrial biogenesis and antioxidant defense. While preclinical data consistently show improvement in skin parameters, clinical translation requires standardized formulations and rigorous safety evaluation. Future directions should integrate omics technologies to identify novel targets and optimize synergistic combinations, bridging traditional medicine with contemporary dermatological research to develop effective, sustainable anti-aging interventions. Supplementary Material File (figure 1.tif) Download 346.58 KB File (figure 2.tif) Download 529.70 KB File (figure 3.tif) Download 1.13 MB File (ms-0424.doc) Download 294.08 KB Information & Authors Information Version history V1 Version 1 24 April 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Authors Affiliations Yi Liu Jiangsu Normal University School of Life Sciences View all articles by this author Dongsheng Shang 0000-0002-8523-8901 Jiangsu Normal University School of Life Sciences View all articles by this author Zhigang Tu [email protected] Jiangsu Normal University School of Life Sciences View all articles by this author Metrics & Citations Metrics Article Usage 227 views 97 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Yi Liu, Dongsheng Shang, Zhigang Tu. Combatting Skin Aging with Chinese Herbal Medicine: Insights into SIRT1/NRF2 Pathway Regulation. Authorea . 24 April 2025. DOI: https://doi.org/10.22541/au.174550684.46199193/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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