The role of peritoneal lavage in benign gynecologic laparoscopic surgery.

Carlo De Cicco Nardone, Fernando Ficarola, Francesco Plotti, Roberto Montera, L. Feole, Stefania Rampello, Gabriele Messina, Daniela Luvero, Roberto Marci, Roberto Angioli, Claudio Terranova
In: European review for medical and pharmacological sciences · 2023 · vol. 27(14) , pp. 6800–6808 · doi:10.26355/eurrev_202307_33151 · PMID:37522691 · W4385406174
article OA: green CC0
📄 Open PDF Full text JSON View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-13 ⓘ

This study randomized 277 women undergoing laparoscopic gynecologic surgery to evaluate if peritoneal lavage with saline reduces postoperative pain and analgesic use, finding it significantly lowered pain and requests for pain medication.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-13 · read from full text ⓘ

This study assessed whether intraperitoneal saline lavage at the end of major benign gynecologic laparoscopic procedures reduces postoperative shoulder pain and analgesic needs, motivated by the idea that washing could remove inflammatory mediators and CO2-related irritants. In a randomized design of 277 women, participants received either peritoneal lavage (YW) or no lavage (NW), and postoperative pain within the first 36 hours and analgesic requests over three days were compared. Peritoneal lavage significantly reduced pain early after surgery and lowered requests for paracetamol and ketorolac during the first three postoperative days. The main caveat is that all procedures were for benign laparoscopic surgery, so findings are specific to this context and outcome timeframe. Relevance to endometriosis: the paper is included in the corpus because it examines postoperative pain mechanisms after gynecologic laparoscopy, an area closely related to endometriosis-associated pelvic pain, though the study does not explicitly analyze endometriosis or adenomyosis patients.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

OBJECTIVE: Laparoscopic surgery offers many advantages compared to invasive surgery but one of the main problems is postoperative pain, partially resulting from the peritoneal inflammatory process mediated by inflammatory cytokines. The rationale of this study is that intraperitoneal washing could remove inflammatory mediators that are the cause of postoperative pain and could help in the removal of CO2 from the abdominal cavity. This article aims to analyze the effects of peritoneal lavage in the reduction of postoperative shoulder pain. PATIENTS AND METHODS: 277 patients enrolled to undergo laparoscopic gynecologic surgery were included in the study. Women are randomized into two groups, according to the use or non-use of peritoneal lavage with saline solution at the end of laparoscopic gynecological major procedures. RESULTS: Data show that the peritoneal lavage can significantly reduce postoperative pain in the first 36 hours after surgery, as well as patients' requests for analgesics: during the first 3 postoperative days, requests for paracetamol were lower in the YW (Yes Washing) group than the NW (No Washing) group (77 vs. 101; p<0.05); similar results are obtained considering ketorolac administration (62 vs. 71; p<0.05). CONCLUSIONS: Peritoneal lavage after gynecological laparoscopic procedures may be effective in the reduction of postoperative pain and use of analgesics.
Full text 2,247 characters · extracted from oa-doi-fallback · 3 sections · click to expand

Objective

Laparoscopic surgery offers many advantages compared to invasive surgery but one of the main problems is postoperative pain, partially resulting from the peritoneal inflammatory process mediated by inflammatory cytokines. The rationale of this study is that intraperitoneal washing could remove inflammatory mediators that are the cause of postoperative pain and could help in the removal of CO2 from the abdominal cavity. This article aims to analyze the effects of peritoneal lavage in the reduction of postoperative shoulder pain. PATIENTS AND METHODS: 277 patients enrolled to undergo laparoscopic gynecologic surgery were included in the study. Women are randomized into two groups, according to the use or non-use of peritoneal lavage with saline solution at the end of laparoscopic gynecological major procedures.

Results

Data show that the peritoneal lavage can significantly reduce postoperative pain in the first 36 hours after surgery, as well as patients’ requests for analgesics: during the first 3 postoperative days, requests for paracetamol were lower in the YW (Yes Washing) group than the NW (No Washing) group (77 vs. 101; p<0.05); similar results are obtained considering ketorolac administration (62 vs. 71; p<0.05).

Conclusions

Peritoneal lavage after gynecological laparoscopic procedures may be effective in the reduction of postoperative pain and use of analgesics. Free PDF DownloadThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License To cite this article C. De Cicco Nardone, F. Ficarola, F. Plotti, R. Montera, L. Feole, S. Rampello, G. Messina, D. Luvero, R. Marci, R. Angioli, C. Terranova The role of peritoneal lavage in benign gynecologic laparoscopic surgery Eur Rev Med Pharmacol Sci Year: 2023 Vol. 27 - N. 14 Pages: 6800-6808 DOI: 10.26355/eurrev_202307_33151 Publication History Published online: 24 Jul 2023

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

Source provenance

openalex
last seen: 2026-05-14T07:21:23.935093+00:00
License: CC0 · commercial use OK