Clinical Effectiveness of Dienogest in the Treatment of Endometriosis

Qiumin Li, Feifei Liu
In: Journal of Clinical and Nursing Research · 2024 · vol. 8(8) , pp. 232–236 · doi:10.26689/jcnr.v8i8.7424 · W4401963700
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Desogestrel treatment in 61 endometriosis patients significantly reduced pain scores and improved HDL-C levels with a 98.36% efficacy rate and low adverse reaction incidence.

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This study evaluated the clinical effectiveness of desogestrel in treating endometriosis by analyzing pain symptom scores and high-density lipoprotein cholesterol levels in 61 patients over one year. The results demonstrated a treatment efficacy rate of 98.36%, with significant reductions in pain scores and improvements in HDL-C levels following the intervention. Although the incidence of adverse reactions was low at 6.55%, the authors note that the study population was limited to a single hospital setting, which may constrain the generalizability of the findings. This paper is centrally about endometriosis, specifically investigating the pharmacological management of the condition using desogestrel to alleviate symptoms and improve lipid profiles.

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Abstract

Objective: This paper aims to investigate the efficacy of desogestrel in the treatment of endometriosis. Methods: In this study, 61 patients with endometriosis in our hospital from January 2023 to December 2023 were selected and divided using the random sampling method. All the patients were treated with desogestrel and the pain symptom scores and HDL-C (high-density lipoprotein cholesterol) levels of the patients were compared before and after the treatment. The treatment effects and adverse effects during the administration of the drug were closely observed. Results: After the patients were treated with desogestrel, the effective rate of treatment was as high as 98.36%, and the incidence of adverse reactions during treatment was 6.55%. Compared with the pre-treatment period, the scores of various pain symptoms were significantly reduced and the HDL-C level was improved after treatment, with P < 0.05. Conclusion: Desogestrel showed significant efficacy in the treatment of endometriosis, effectively relieving patients’ pain while elevating HDL-C levels. In addition, the incidence of adverse reactions to this drug is relatively low, which is worth utilizing.
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Clinical Effectiveness of Dienogest in the Treatment of Endometriosis Objective: This paper aims to investigate the efficacy of desogestrel in the treatment of endometriosis. Methods: In this study, 61 patients with endometriosis in our hospital from January 2023 to December 2023 were selected and divided using the random sampling method. All the patients were treated with desogestrel and the pain symptom scores and HDL-C (high-density lipoprotein cholesterol) levels of the patients were compared before and after the treatment. The treatment effects and adverse effects during the administration of the drug were closely observed. Results: After the patients were treated with desogestrel, the effective rate of treatment was as high as 98.36%, and the incidence of adverse reactions during treatment was 6.55%. Compared with the pre-treatment period, the scores of various pain symptoms were significantly reduced and the HDL-C level was improved after treatment, with P < 0.05. Conclusion: Desogestrel showed significant efficacy in the treatment of endometriosis, effectively relieving patients’ pain while elevating HDL-C levels. In addition, the incidence of adverse reactions to this drug is relatively low, which is worth utilizing. Yao HL, Liang NN, 2023, Effectiveness of Mifepristone Combined with Dienogest in the Treatment of Dysmenorrhea in Endometriosis. Clinical Medical Eng, 30(10): 1399–1400. Li L, Wang A, Peng L, 2023, Observation on the Clinical Effect of Warming Menstruation and Resolving Symptoms in Combination with Desogestrel in the Treatment of Endometriosis. Chinese Journal of Family Planning, 31(10): 2443–2446 + 2451. Tian H, 2023, Effect of Dienogest Drug Treatment of Ovarian Endometriosis on Cyst Diameter, Associated Pain and Ovarian Reserve. Harbin Medicine, 43(05): 20–22. Chen Y, Feng C, 2023, Treatment of Endometriosis by Gui Zhi Fu Ling Wan Combined with Desogestrel and Improvement of Endometrial Receptivity. China Drugs & Clinics, 23(07): 461–465. Shao L, Wang H, Yang Z, 2023, Effect of Dienogest Combined with Laparoscopic Surgery for the Treatment of Endometriosis Infertility on Patients’ Serum AMH, VEGF and Clinical Pregnancy. Chinese Journal of Family Planning, 31(11): 2593–2596 + 2600. Huang WR, Mi JF, 2023, Comparison of Efficacy and Safety Between Dienogest and Gonadotropin-Releasing Hormone Agonist Combined with Laparoscopic Surgery for Endometriosis. Clinical Rational Drug Use, 16(33): 104–107. Wang HY, 2023, Effect of Dienogest on Recurrence and Ovarian Reserve Function After Laparoscopic Surgery in Patients with Endometriotic Cysts of the Ovary in Reproductive Age. China Practical Medicine, 18(19): 95–98. Ren H, Liu M, Dong X, et al., 2023, New Progress of Dienogest in the Pharmacologic Treatment of Endometriosis. Maternal and Child Health Care of China, 38(19): 3839–3842. Luo Y, Huang Z, Lei J, et al., 2023, Analysis of High-Risk Factors for the Clinical Outcome of Levonorgestrel Intrauterine Device System Combined with Dienogest in the Treatment of Adenomyosis. Clinical Misdiagnosis and Mistreatment, 36(09): 72–77. Wu WT, Shen QL, Dong J, et al., 2023, Effect of Dienogest on Improving Lesion Size and Clinical Efficacy of Sex Hormone Levels in Patients with Endometriosis. Maternal and Child Health Care of China, 38(17): 3199–3202. Cheng J, Hong N, 2023, Effect of Drospirenone Ethinyl Estradiol and Dienogest Combined with Surgery in the Treatment of Endometriosis and Its Effect on Serum Estrogen and Menstrual Flow. Chinese Journal of Family Planning, 31(08): 1893–1896. Zhang S, Chang R, Guo C, 2023, Laparoscopic Surgery Combined with Anti-Infection and Dienogest Treatment. A Clinical Study of Endometriosis. Journal of Localized Surgery, 32(08): 708–711. Feng D, 2023, A Comparison of Dienogest and GnRH-a for the Treatment on Maintenance Therapy of Endometriosis After Fertility-Preserving Surgery: A Meta-Analysis, Master’s thesis, Jiamusi University. Ling X, Chen J, 2023, Clinical Effect of Dienogest in Conservative Treatment of Ovarian Endometriosis Cyst. Maternal and Child Health Care of China, 38(24): 4879–4883. Guo D, 2023, Analysis of the Effect and Recurrence Rate of Laparoscopy Combined with Dienogest in the Treatment of Ovarian Endometriosis. Journal of Women’s and Children’s Health, 2(06): 45–47 + 50.

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