Evaluation of serum CA_(125) and endometrial antibody for the diagnosis of endometriosis

ObjectiveTo discuss the clinical value of serum CA 125 and endometrial antibody (EMAb) for the diagnosis of endometriosis.Methods216 patients were determined by the presences of CA 125 and EMAb before operation.ResultsAll cases were diagnosed by pathology after operation. CA 125 positive rate in the endometriosis group was 58.3% and that in the control group was 12.5 %. The difference between two groups was significant ( P0.01). EMAb positive rate in the endometriosis group was 31.3% and that in the control group was 14.3%. The difference between two groups was also significant ( P0.01). When determining CA 125 alone to diagnose endometriosis, the sensitivity rate was 58.3% and specificity rate was 87.5%. If determining EMAb alone to diagnose endometriosis, the sensitivity rate was 31.3% and specificity rate was 85.7%. When one of them was used as diagnostic criterion, the sensitivity and specificity were 64.6% and 73.2% respectively. If combining use of both CA 125 and EMAb as diagnostic criterion, the sensitivity and specificity were 25.0% and 100% respectively.Conclusions The determination of serum CA 125 or EMAb levels is helpful for the qualitative diagnosis of endometriosis, especially using them combined, the diagnostic accuracy may be enhanced.