Traffic Congestion: A rare cause of systemic hypertension

Traffic Congestion: A rare cause of systemic hypertension | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Traffic Congestion: A rare cause of systemic hypertension Rachel Mayo, Michael Bishop, Brendan Crawford This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8408714/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 11 Feb, 2026 Read the published version in Pediatric Nephrology → Version 1 posted 5 You are reading this latest preprint version Abstract Secondary hypertension – the presence of an underlying medical condition as a cause for elevated blood pressure – is suspected when hypertension occurs in young, thin children. We highlight a unique presentation and underlying medical condition, polycythemia vera (PV), as the cause of secondary hypertension in an asymptomatic 5-year-old child presenting for a routine physical examination and found to have hypertensive urgency. Laboratory evaluations revealed leukocytosis, polycythemia, thrombocytosis, and low erythropoietin level. JAK2-V617F mutational analysis confirmed the diagnosis of PV. She was managed with antihypertensive medications, therapeutic phlebotomy, and cytoreductive therapy with notable improvement in hypertension over time. She continues regular follow-up with nephrology and hematology/oncology. She has not had any further serious complications or evolution of her PV. This case demonstrates the importance of a broad differential diagnosis in the setting of very early onset hypertension, including myeloproliferative disorders. Hypertension polycythemia vera JAK2-V617F complete blood count Full Text Cite Share Download PDF Status: Published Journal Publication published 11 Feb, 2026 Read the published version in Pediatric Nephrology → Version 1 posted Editorial decision: Major Revisions Needed 09 Jan, 2026 Reviewers agreed at journal 30 Dec, 2025 Reviewers invited by journal 30 Dec, 2025 Editor assigned by journal 30 Dec, 2025 First submitted to journal 19 Dec, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-8408714","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":567277205,"identity":"1e47403e-41db-46bd-a7c5-1f00a3737b22","order_by":0,"name":"Rachel Mayo","email":"","orcid":"","institution":"UAMS: University of Arkansas for Medical Sciences","correspondingAuthor":false,"prefix":"","firstName":"Rachel","middleName":"","lastName":"Mayo","suffix":""},{"id":567277206,"identity":"90e8ad1b-9117-49d9-8822-7eb9a8e93dc6","order_by":1,"name":"Michael Bishop","email":"","orcid":"","institution":"UAMS: University of Arkansas for Medical 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