INHAND: Non-proliferative and proliferative lesions of fish - Chapter 3. Fish digestive system

Baumgartner W, Wes Baumgartner, Bach U, Ute Bach, James Baily, Baily J, Ruehl-Fehlert C, Christine Ruehl-Fehlert, Fossey S, Stacey Fossey, Satoshi Furukawa, Furukawa S, Yuki Kato, Kato Y, Victoria Laast, Laast V, Meseck E, Emily Meseck, Heike Schmidt-Posthaus, Schmidt-Posthaus H, Helmut Segner, Segner H, Shanmukhappa SK, Shiva Kumar Shanmukhappa, Jan Spitsbergen, Spitsbergen J, Jeffrey Wolf, Wolf J
Journal of toxicologic pathology · 2026 · vol. 39(2 Suppl) , pp. 24S–65S · doi:10.1293/tox.2025-0193 · PMID:42416802 · PMC13340203
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⚙ AI-generated summary by qwen3.7-flash+body, 2026-09-08 ⓘ

This chapter presents diagnostic criteria, nomenclature, and histologic findings for non-proliferative and proliferative lesions in fish digestive system target tissues.

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This chapter provides a comprehensive overview of the normal anatomy, histology, and pathological findings within the digestive systems of various fish species, including zebrafish and salmonids. It details specific technical challenges in tissue fixation and necropsy procedures, while describing structural differences such as the presence or absence of stomachs and distinct intestinal segmentation compared to mammals. The text also outlines common spontaneous lesions, infectious diseases, and neoplastic patterns observed in these aquatic models used for carcinogenicity screening. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Intro

Except for body form and skin, the gastrointestinal tract and its appendages are the most variable organ system in fishes. Fish gastrointestinal tract, gas bladder, and exocrine pancreas are often target tissues for drugs, toxicants and environmental pollutants. To date, no central repository of information regarding diagnostic criteria, nomenclature, and similarities and differences when comparing fish to mammals has been available with regard to these target tissues. Spontaneous and age-related lesions, lesions induced by exposure to test agents, common infectious and parasitic findings are presented.

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( Fig. 3.91 Fig. 3.91. Zebrafish. Exocrine pancreas. Adenoma, acinar cell. H&E. ) Zebrafish. Exocrine pancreas. Adenoma, acinar cell. H&E. ( Fig. 3.92 Fig. 3.92. Zebrafish. Exocrine pancreas. Adenoma, duct. H&E. Fig. 3.93. Zebrafish. Exocrine pancreas. Adenocarcinoma, acinar. H&E. ) Zebrafish. Exocrine pancreas. Adenoma, duct. H&E. Zebrafish. Exocrine pancreas. Adenocarcinoma, acinar. H&E. ( Figs. 3.86 and 3.93 ) ( Figs. 3.94 and 3.95 Fig. 3.94. Zebrafish (TL line). Exocrine pancreas. Adenocarcinoma, ductal. Near ampulla of Vater. H&E. Fig. 3.95. Zebrafish (TL line). Exocrine pancreas. Adenocarcinoma, ductal. Near ampulla of Vater, higher magnification of Fig. 3.94 . H&E. ) Zebrafish (TL line). Exocrine pancreas. Adenocarcinoma, ductal. Near ampulla of Vater. H&E. Zebrafish (TL line). Exocrine pancreas. Adenocarcinoma, ductal. Near ampulla of Vater, higher magnification of Fig. 3.94 . H&E.

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