Immunomodulatory role and therapeutic potential of thrombospondin-1 during infectious diseases

Infectious diseases are a leading cause of morbidity and mortality worldwide. The lack of vaccines against some major pathogens and the acquisition of resistance to current treatments by others highlight the importance of developing novel therapeutics against clinically relevant microbes. In this context, identifying relevant host-derived proteins involved in host defense is key to designing therapeutic strategies to improve the host’s immune response during infection. Thrombospondin 1 (TSP-1), a homotrimer host glycoprotein expressed in the extracellular matrix, is involved in several biological and cellular processes, including host defense during infection. The structure of TSP-1 comprises five domains that allow its interaction with diverse ligands. Here, we first analyze how TSP-1 interacts with different ligands involved in immunity. Then, we discuss the role of TSP-1 during different in vitro and in vivo infection models. Finally, we examine the therapeutic potential of TSP-1, revisiting therapeutic approaches based on TSP-1 and their protection mechanisms in response to different infectious and non-infectious diseases. Information & Authors Information Version history Copyright This work is licensed under a Non Exclusive No Reuse License.

Authors Metrics & Citations Metrics Article Usage 209views 111downloads Citations Download citation Francisca Román, Aillairlyn Jara, Agnes Jara-Collao, et al. Immunomodulatory role and therapeutic potential of thrombospondin-1 during infectious diseases. Authorea. 22 March 2025. DOI: https://doi.org/10.22541/au.174263973.31970606/v1 DOI: https://doi.org/10.22541/au.174263973.31970606/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu.